Klas Wictorin

Ex vivo and in vitro studies of transgene expression in rat astrocytes transduced with lentiviral vectors. (2002)

Ericson, Cecilia, Wictorin, Klas, Lundberg, Cecilia

Implantation of cells genetically modified to express therapeutic genes into the brain has been proposed as a potential treatment for neurodegenerative diseases. In the current study embryonic...

Transplantation of human neural progenitor cells into the neonatal rat brain: extensive migration and differentiation with long-distance axonal projections. (2002)

Englund, Ulrica, Fricker-Gates, Rosemary A, Lundberg, Cecilia, Björklund, Anders, Wictorin, Klas

Here we examined the ability of human neural progenitors from the embryonic forebrain, expanded for up to a year in culture in the presence of growth factors, to respond to environmental signals...

Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain. (2002)

Englund, Ulrica, Björklund, Anders, Wictorin, Klas

We have examined long-term growth-factor expanded human neural progenitors following transplantation into the adult rat brain. Cells, obtained from the forebrain of a 9-week old fetus, propagated in...

Differentiation of the RN33B Cell Line into Forebrain Projection Neurons after Transplantation into the Neonatal Rat Brain. (2002)

Lundberg, Cecilia, Englund, Ulrica, Trono, Didier, Björklund, Anders, Wictorin, Klas

The rat neural cell line RN33B has a remarkable ability to undergo region-specific neuronal differentiation after transplantation into the CNS. To further study its neurogenic properties in vivo, we...

Subretinal Transplantation of Brain-derived Precursor Cells to Young RCS Rats Promotes Photoreceptor Cell Survival( small star, filled). (2002)

Blixt Wojciechowski, Anita, Englund, Ulrica, Lundberg, Cecilia, Wictorin, Klas, Warfvinge, Karin

The potential use of in vitro-expanded precursor cells or cell lines in brain repair includes transplantation of such cells for cell replacement purposes and the activation of host cells to provide...

Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brain. (2002)

Lundberg, Cecilia, Englund, Ulrica, Trono, Didier, Björklund, Anders, Wictorin, Klas

The rat neural cell line RN33B has a remarkable ability to undergo region-specific neuronal differentiation after transplantation into the CNS. To further study its neurogenic properties in vivo, we...

Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry

Englund, Ulrica, Björklund, Anders, Wictorin, Klas, Lindvall, Olle, Kokaia, Merab

In vitro expanded neural stem/progenitor cells can undergo region-specific differentiation after transplantation to the developing or adult brain, and display morphologies and markers characteristic...

Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry

Englund, Ulrica, Björklund, Anders, Wictorin, Klas, Lindvall, Olle, Kokaia, Merab

In vitro expanded neural stem/progenitor cells can undergo region-specific differentiation after transplantation to the developing or adult brain, and display morphologies and markers characteristic...