A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity
Yamamoto, Shingo, Kiyono, Hiroshi, Yamamoto, Masafumi, Imaoka, Koichi, Yamamoto, Miho, Fujihashi, Kohtaro, ...
We have characterized a nontoxic mutant of cholera toxin (CT) as a mucosal adjuvant in mice. The mutant CT was made by substitution of serine with phenylalanine at position 61 of the A subunit...
A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity
Yamamoto, Shingo, Kiyono, Hiroshi, Yamamoto, Masafumi, Imaoka, Koichi, Yamamoto, Miho, Fujihashi, Kohtaro, ...
We have characterized a nontoxic mutant of cholera toxin (CT) as a mucosal adjuvant in mice. The mutant CT was made by substitution of serine with phenylalanine at position 61 of the A subunit...
Yamamoto, Shingo, Takeda, Yoshifumi, Yamamoto, Masafumi, Kurazono, Hisao, Imaoka, Koichi, Yamamoto, Miho, ...
Cholera toxin (CT), the most commonly used mucosal adjuvant in experimental animals, is unsuitable for humans because of potent diarrhea-inducing properties. We have constructed two CT-A subunit...