Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells (2005)
Lina E. Tze, Brian R. Schram, Kong-Peng Lam, Kristin A. Hogquist, Keli L. Hippen, Jiabin Liu, ...
Gene rearrangement is a hallmark of B cell maturation. By interrupting basal cell signaling through the rearranged IgM receptor, immature B cells "back-differentiate" to an earlier stage in their...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells (2005)
Lina E. Tze, Brian R. Schram, Kong-Peng Lam, Kristin A. Hogquist, Keli L. Hippen, Jiabin Liu, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
Novobrantseva, Tatiana, Xu, Shengli, Tan, Joy En-Lin, Maruyama, Mitsuo, Schwers, Stephan, Pelanda, Roberta, ...
We examined the generation and selection of the B cell antibody repertoire through crossing of mice bearing distinct Ig heavy (H) and light (L) chain rearranged variable region transgenes. Ig gene...
Novobrantseva, Tatiana, Xu, Shengli, Tan, Joy En-Lin, Maruyama, Mitsuo, Schwers, Stephan, Pelanda, Roberta, ...
We examined the generation and selection of the B cell antibody repertoire through crossing of mice bearing distinct Ig heavy (H) and light (L) chain rearranged variable region transgenes. Ig gene...
Xu, Shengli, Tan, Joy En-Lin, Wong, Esther Poh-Ying, Manickam, Arunkumar, Ponniah, Sathivel, Lam, Kong-Peng
Engagement of the B cell receptor (BCR) leads to the activation of tyrosine kinases and other signaling molecules that ultimately determine the type and magnitude of the B lymphocyte's cellular...
Fetal- and adult-type B cell development /--Kong-Peng Lam. (1994)
Department: Microbiology
Fetal- and adult-type B cell development--[microform] /--Kong-Peng Lam. (1994)
Department: Microbiology
Lam, Kong-Peng, Herzenberg, L. A., Stall, A. M., Okumura, K.
The M54 transgenic mouse line, which carries the 17.2.25 Ig μ heavy chain gene, rearranges Ig eavy chains and expresses both transgenic and endogenous μ. B cell lineage development is selectively...
Lam, Kong-Peng, Rajewsky, Klaus
Developing autoreactive B cells edit their B cell antigen receptor (BCR) in the bone marrow and are clonally deleted when they fail to reexpress an innocent BCR. Here, inducible Cre-loxP-mediated...
B-cell maturation protein (BCMA) is a member of the tumor necrosis factor (TNF) receptor family and is expressed in B lymphocytes. BCMA binds two TNF family members, BAFF and APRIL, that stimulate...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
Tze, Lina E, Schram, Brian R, Lam, Kong-Peng, Hogquist, Kristin A, Hippen, Keli L, Liu, Jiabin, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
Cbp Deficiency Alters Csk Localization in Lipid Rafts but Does Not Affect T-Cell Development
Xu, Shengli, Huo, Jianxin, Tan, Joy En-Lin, Lam, Kong-Peng
The ubiquitously expressed transmembrane adaptor Csk-binding protein (Cbp) recruits Csk to lipid rafts, where the latter exerts its negative regulatory effect on the Src family of protein tyrosine...
Lam, Kong-Peng, Rajewsky, Klaus
Developing autoreactive B cells edit their B cell antigen receptor (BCR) in the bone marrow and are clonally deleted when they fail to reexpress an innocent BCR. Here, inducible Cre-loxP-mediated...
B-cell maturation protein (BCMA) is a member of the tumor necrosis factor (TNF) receptor family and is expressed in B lymphocytes. BCMA binds two TNF family members, BAFF and APRIL, that stimulate...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
Tze, Lina E, Schram, Brian R, Lam, Kong-Peng, Hogquist, Kristin A, Hippen, Keli L, Liu, Jiabin, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
Cbp Deficiency Alters Csk Localization in Lipid Rafts but Does Not Affect T-Cell Development
Xu, Shengli, Huo, Jianxin, Tan, Joy En-Lin, Lam, Kong-Peng
The ubiquitously expressed transmembrane adaptor Csk-binding protein (Cbp) recruits Csk to lipid rafts, where the latter exerts its negative regulatory effect on the Src family of protein tyrosine...
TACI and BAFF-R mediate isotype switching in B cells
Castigli, Emanuela, Wilson, Stephen A., Scott, Sumi, Dedeoglu, Fatma, Xu, Shengli, Lam, Kong-Peng, ...
The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1,...
B cell linker (BLNK) protein is a component of the B cell receptor (BCR) signaling pathway and BLNK−/− mice have a block in B lymphopoiesis at the pro-B/pre-B cell stage. To study the effect of...
Lam, Kong-Peng, Rajewsky, Klaus
Mice expressing the immunoglobulin (Ig) heavy (H) chain variable (V) region from a rearranged VH12 gene inserted into the IgH locus generate predominantly B-1 cells, whereas expression of two other...