Reprogramming of a melanoma genome by nuclear transplantation (2004)
Hochedlinger, Konrad, Blelloch, Robert, Brennan, Cameron, Yamada, Yasuhiro, Kim, Minjung, Chin, Lynda, ...
We have used nuclear transplantation to test whether the reprogramming activity of oocytes can reestablish developmental pluripotency of malignant cancer cells. We show here that the nuclei of...
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei
Humpherys, David, Eggan, Kevin, Akutsu, Hidenori, Friedman, Adam, Hochedlinger, Konrad, Yanagimachi, Ryuzo, ...
To assess the extent of abnormal gene expression in clones, we assessed global gene expression by microarray analysis on RNA from the placentas and livers of neonatal cloned mice derived by nuclear...
Gribnau, Joost, Hochedlinger, Konrad, Hata, Ken, Li, En, Jaenisch, Rudolf
Genomic imprinting in mammals marks the two parental alleles resulting in differential gene expression. Imprinted loci are characterized by distinct epigenetic modifications such as differential DNA...
Reprogramming of a melanoma genome by nuclear transplantation
Hochedlinger, Konrad, Blelloch, Robert, Brennan, Cameron, Yamada, Yasuhiro, Kim, Minjung, Chin, Lynda, ...
We have used nuclear transplantation to test whether the reprogramming activity of oocytes can reestablish developmental pluripotency of malignant cancer cells. We show here that the nuclei of...
Nuclear cloning of embryonal carcinoma cells
Blelloch, Robert H., Hochedlinger, Konrad, Yamada, Yasuhiro, Brennan, Cameron, Kim, Minjung, Mintz, Beatrice, ...
Embryonal carcinoma (EC) cells have served as a model to study the relationship between cancer and cellular differentiation given their potential to produce tumors and, to varying degrees,...
Direct in vivo VH to JH rearrangement violating the 12/23 rule
Koralov, Sergei B., Novobrantseva, Tatiana I., Hochedlinger, Konrad, Jaenisch, Rudolf, Rajewsky, Klaus
V(D)J recombination at the immunoglobulin heavy chain (IgH) locus follows the 12/23 rule to ensure the correct assembly of the variable region gene segments. Here, we report characterization of an in...
Brambrink, Tobias, Hochedlinger, Konrad, Bell, George, Jaenisch, Rudolf
Reproductive cloning is uniformly rejected as a valid technology in humans because of the severely abnormal phenotypes seen in cloned animals. Gene expression aberrations observed in tissues of...
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei
Humpherys, David, Eggan, Kevin, Akutsu, Hidenori, Friedman, Adam, Hochedlinger, Konrad, Yanagimachi, Ryuzo, ...
To assess the extent of abnormal gene expression in clones, we assessed global gene expression by microarray analysis on RNA from the placentas and livers of neonatal cloned mice derived by nuclear...
Gribnau, Joost, Hochedlinger, Konrad, Hata, Ken, Li, En, Jaenisch, Rudolf
Genomic imprinting in mammals marks the two parental alleles resulting in differential gene expression. Imprinted loci are characterized by distinct epigenetic modifications such as differential DNA...
Reprogramming of a melanoma genome by nuclear transplantation
Hochedlinger, Konrad, Blelloch, Robert, Brennan, Cameron, Yamada, Yasuhiro, Kim, Minjung, Chin, Lynda, ...
We have used nuclear transplantation to test whether the reprogramming activity of oocytes can reestablish developmental pluripotency of malignant cancer cells. We show here that the nuclei of...
Nuclear cloning of embryonal carcinoma cells
Blelloch, Robert H., Hochedlinger, Konrad, Yamada, Yasuhiro, Brennan, Cameron, Kim, Minjung, Mintz, Beatrice, ...
Embryonal carcinoma (EC) cells have served as a model to study the relationship between cancer and cellular differentiation given their potential to produce tumors and, to varying degrees,...
Brambrink, Tobias, Hochedlinger, Konrad, Bell, George, Jaenisch, Rudolf
Reproductive cloning is uniformly rejected as a valid technology in humans because of the severely abnormal phenotypes seen in cloned animals. Gene expression aberrations observed in tissues of...
X chromosome choice occurs independently of asynchronous replication timing
Gribnau, Joost, Luikenhuis, Sandra, Hochedlinger, Konrad, Monkhorst, Kim, Jaenisch, Rudolf
In mammals, dosage compensation is achieved by X chromosome inactivation in female cells. Xist is required and sufficient for X inactivation, and Xist gene deletions result in completely skewed X...
Direct in vivo VH to JH rearrangement violating the 12/23 rule
Koralov, Sergei B., Novobrantseva, Tatiana I., Hochedlinger, Konrad, Jaenisch, Rudolf, Rajewsky, Klaus
V(D)J recombination at the immunoglobulin heavy chain (IgH) locus follows the 12/23 rule to ensure the correct assembly of the variable region gene segments. Here, we report characterization of an in...
Fibroblast-Derived Induced Pluripotent Stem Cells Show No Common Retroviral Vector Insertions
Varas, Florencio, Stadtfeld, Matthias, Maherali, Nimet, Di Tullio, Alessandro, Pantano, Lorena, ...
Several laboratories have reported the reprogramming of mouse and human fibroblasts into pluripotent cells, using retroviruses carrying the Oct4, Sox2, Klf4, and c-Myc transcription factor genes. In...