Koret Hirschberg

(Griffiths et al., 1984; Wieland et al., 1987), for ensuring (2008)

Carolyn L. Smith, Roman S. Polishchuk, Nihal Altan, Nelson B. Cole, Jan Ellenberg, ...

to ER recycling is necessary for maintaining the surface area of the ER in the face of outward secretory traffic

Retention of pendrin in the endoplasmic reticulum is a major mechanism for Pendred syndrome (2002)

Rotman-Pikielny, Pnina, Hirschberg, Koret, Maruvada, Padma, Suzuki, Koichi, Royaux, Ines E., Green, Eric D., ...

Pendred syndrome is a major cause of congenital deafness, goiter and defective iodide organification. Mutations in the transmembrane protein, pendrin, cause diminished export of iodide from thyroid...

Neuronal Calcium Sensor-1 and Phosphatidylinositol 4-Kinase β Stimulate Extracellular Signal-regulated Kinase 1/2 Signaling by Accelerating Recycling through the Endocytic Recycling Compartment

Kapp-Barnea, Yaara, Ninio-Many, Lihi, Hirschberg, Koret, Fukuda, Mitsunori, Jeromin, Andreas, Sagi-Eisenberg, Ronit

We demonstrate that recycling through the endocytic recycling compartment (ERC) is an essential step in FcεRI-induced activation of extracellular signal-regulated kinase (ERK)1/2. We show that...

Neuronal Calcium Sensor-1 and Phosphatidylinositol 4-Kinase β Stimulate Extracellular Signal-regulated Kinase 1/2 Signaling by Accelerating Recycling through the Endocytic Recycling Compartment

Kapp-Barnea, Yaara, Ninio-Many, Lihi, Hirschberg, Koret, Fukuda, Mitsunori, Jeromin, Andreas, Sagi-Eisenberg, Ronit

We demonstrate that recycling through the endocytic recycling compartment (ERC) is an essential step in FcεRI-induced activation of extracellular signal-regulated kinase (ERK)1/2. We show that...

Kinetic Analysis of Secretory Protein Traffic and Characterization of Golgi to Plasma Membrane Transport Intermediates in Living Cells

Hirschberg, Koret, Miller, Chad M., Ellenberg, Jan, Presley, John F., Siggia, Eric D., Phair, Robert D., ...

Quantitative time-lapse imaging data of single cells expressing the transmembrane protein, vesicular stomatitis virus ts045 G protein fused to green fluorescent protein (VSVG–GFP), were used for...

Rapid Cycling of Lipid Raft Markers between the Cell Surface and Golgi Complex

Nichols, Benjamin J., Kenworthy, Anne K., Polishchuk, Roman S., Lodge, Robert, Roberts, Theresa H., Hirschberg, Koret, ...

The endocytic itineraries of lipid raft markers, such as glycosyl phosphatidylinositol (GPI)-anchored proteins and glycosphingolipids, are incompletely understood. Here we show that different...

Maintenance of Golgi structure and function depends on the integrity of ER export

Ward, Theresa H., Polishchuk, Roman S., Caplan, Steve, Hirschberg, Koret, Lippincott-Schwartz, Jennifer

The Golgi apparatus comprises an enormous array of components that generate its unique architecture and function within cells. Here, we use quantitative fluorescence imaging techniques and...

Coordinated Lipid Transfer between the Endoplasmic Reticulum and the Golgi Complex Requires the VAP Proteins and Is Essential for Golgi-mediated Transport

Peretti, Diego, Dahan, Nili, Shimoni, Eyal, Hirschberg, Koret, Lev, Sima

Lipid transport between intracellular organelles is mediated by vesicular and nonvesicular transport mechanisms and is critical for maintaining the identities of different cellular membranes....

Clustering and Lateral Concentration of Raft Lipids by the MAL Protein

Magal, Lee Goldstein, Yaffe, Yakey, Shepshelovich, Jeanne, Aranda, Juan Francisco, Gaus, Katharina, ...

MAL, a compact hydrophobic, four-transmembrane-domain apical protein that copurifies with detergent-resistant membranes is obligatory for the machinery that sorts glycophosphatidylinositol...