The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA (2009)
López De Silanes, Isabel, Gorospe, Myriam, Taniguchi, Hiroaki, Abdelmohsen, Kotb, Srikantan, Subramanya, Alaminos, Miguel, ...
The molecular basis underlying the aberrant DNA-methylation patterns in human cancer is largely unknown. Altered DNA methyltransferase (DNMT) activity is believed to contribute, as DNMT expression...
Nuclear HuR accumulation through phosphorylation by Cdk1 (2008)
Kim, Hyeon Ho, Abdelmohsen, Kotb, Lal, Ashish, Pullmann, Rudolf, Yang, Xiaoling, Galban, Stefanie, ...
A predominantly nuclear RNA-binding protein, HuR translocates to the cytoplasm in response to stress and proliferative signals, where it stabilizes or modulates the translation of target mRNAs. Here,...
The effect of redox cycling and alkylating quinones on epidermal growth factor receptor (EGFR) dependent signaling pathways and consequences thereof were investigated. Rat liver epithelial cells were...
Düsseldorf, University, Diss., 2003 (Nicht für den Austausch).
Düsseldorf, University, Diss., 2003.
Pullmann, Rudolf, Kim, Hyeon Ho, Abdelmohsen, Kotb, Lal, Ashish, Martindale, Jennifer L., Yang, Xiaoling, ...
RNA-binding proteins (RBPs) that associate with specific mRNA sequences and function as mRNA turnover and translation regulatory (TTR) RBPs are emerging as pivotal posttranscriptional regulators of...
p16INK4a Translation Suppressed by miR-24
Lal, Ashish, Kim, Hyeon Ho, Abdelmohsen, Kotb, Kuwano, Yuki, Pullmann, Rudolf, Srikantan, Subramanya, ...
RNA-Binding Proteins HuR and PTB Promote the Translation of Hypoxia-Inducible Factor 1α▿ †
Galbán, Stefanie, Kuwano, Yuki, Pullmann, Rudolf, Martindale, Jennifer L., Kim, Hyeon Ho, Lal, Ashish, ...
The levels of hypoxia-inducible factor 1α (HIF-1α) are tightly controlled. Here, we investigated the posttranscriptional regulation of HIF-1α expression in human cervical carcinoma HeLa cells...
MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90▿ †
Kuwano, Yuki, Kim, Hyeon Ho, Abdelmohsen, Kotb, Pullmann, Rudolf, Martindale, Jennifer L., Yang, Xiaoling, ...
The mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) plays a major role in dephosphorylating and thereby inactivating the MAP kinases extracellular signal-regulated kinase (ERK), c-Jun...
Nuclear HuR accumulation through phosphorylation by Cdk1
Kim, Hyeon Ho, Abdelmohsen, Kotb, Lal, Ashish, Pullmann, Rudolf, Yang, Xiaoling, Galban, Stefanie, ...
A predominantly nuclear RNA-binding protein, HuR translocates to the cytoplasm in response to stress and proliferative signals, where it stabilizes or modulates the translation of target mRNAs. Here,...
The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA
López De Silanes, Isabel, Gorospe, Myriam, Taniguchi, Hiroaki, Abdelmohsen, Kotb, Srikantan, Subramanya, Alaminos, Miguel, ...
The molecular basis underlying the aberrant DNA-methylation patterns in human cancer is largely unknown. Altered DNA methyltransferase (DNMT) activity is believed to contribute, as DNMT expression...
miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels
Abdelmohsen, Kotb, Srikantan, Subramanya, Kuwano, Yuki, Gorospe, Myriam
Gene expression is potently regulated through the action of RNA-binding proteins (RBPs) and microRNAs (miRNAs). Here, we present evidence of a miRNA regulating an RBP. The RBP HuR can stabilize and...