Kouichi Hashimoto

Diminished climing fiber innervation of Purkinje cells in the cerebellum of myosin Va mutant mice and rats (2007)

Takagishi, Yoshiko, Hashimoto, Kouichi, Kayahara, Tetsuro, Watanabe, Masahiko, Otsuka, Hiroyuki, Mizoguchi, Akira, ...

Running title: Climbing fibers in myosin Va mutants

Phospholipase Cbeta 4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum (1998)

Kano, Masanobu, Hashimoto, Kouichi, Watanabe, Masahiko, Kurihara, Hideo, Offermanns, Stefan, Jiang, Huiping, ...

Elimination of excess climbing fiber (CF)-Purkinje cell synapses during cerebellar development involves a signaling pathway that includes type 1 metabotropic glutamate receptor, Galpha q, and the...

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Galpha q (1997)

Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...

Mice lacking the alpha -subunit of the heterotrimeric guanine nucleotide binding protein Gq (Galpha q) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of...

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking G alpha q (1997)

Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...

Mice lacking the alpha-subunit of the heterotrimeric guanine nucleotide binding protein G(q) (G alpha(q)) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of...

Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum

Kano, Masanobu, Hashimoto, Kouichi, Watanabe, Masahiko, Kurihara, Hideo, Offermanns, Stefan, Jiang, Huiping, ...

Elimination of excess climbing fiber (CF)–Purkinje cell synapses during cerebellar development involves a signaling pathway that includes type 1 metabotropic glutamate receptor, Gαq, and the γ...

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq

Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...

Mice lacking the α-subunit of the heterotrimeric guanine nucleotide binding protein Gq (Gαq) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of the...

Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA

Tabata, Toshihide, Araishi, Kenji, Hashimoto, Kouichi, Hashimotodani, Yuki, Van Der Putten, Herman, Bettler, Bernhard, ...

Type B γ-aminobutyric acid receptor (GABABR) is a G protein-coupled receptor that regulates neurotransmitter release and neuronal excitability throughout the brain. In various neurons, GABABRs are...

Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum

Kano, Masanobu, Hashimoto, Kouichi, Watanabe, Masahiko, Kurihara, Hideo, Offermanns, Stefan, Jiang, Huiping, ...

Elimination of excess climbing fiber (CF)–Purkinje cell synapses during cerebellar development involves a signaling pathway that includes type 1 metabotropic glutamate receptor, Gαq, and the γ...

Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking Gαq

Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...

Mice lacking the α-subunit of the heterotrimeric guanine nucleotide binding protein Gq (Gαq) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of the...

Ca2+ activity at GABAB receptors constitutively promotes metabotropic glutamate signaling in the absence of GABA

Tabata, Toshihide, Araishi, Kenji, Hashimoto, Kouichi, Hashimotodani, Yuki, Van Der Putten, Herman, Bettler, Bernhard, ...

Type B γ-aminobutyric acid receptor (GABABR) is a G protein-coupled receptor that regulates neurotransmitter release and neuronal excitability throughout the brain. In various neurons, GABABRs are...

Presynaptic origin of paired-pulse depression at climbing fibre–Purkinje cell synapses in the rat cerebellum

Hashimoto, Kouichi, Kano, Masanobu

Climbing fibre-mediated excitatory postsynaptic potentials (CF-EPSPs) or currents (CF-EPSCs) were recorded from Purkinje cells in rat cerebellar slices using the whole-cell recording...

Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity

Kakizawa, Sho, Kishimoto, Yasushi, Hashimoto, Kouichi, Miyazaki, Taisuke, Furutani, Kazuharu, Shimizu, Hidemi, ...

Functional crosstalk between cell-surface and intracellular ion channels plays important roles in excitable cells and is structurally supported by junctophilins (JPs) in muscle cells. Here, we report...

G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells

Tabata, Toshihide, Kawakami, Daisuke, Hashimoto, Kouichi, Kassai, Hidetoshi, Yoshida, Takayuki, Hashimotodani, Yuki, ...

Adenosine receptors (ARs) are G protein-coupled receptors (GPCRs) mediating the neuromodulatory actions of adenosine that influence emotional, cognitive, motor, and other functions in the central...

Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination

Kano, Masanobu, Hashimoto, Kouichi, Tabata, Toshihide

The cerebellum is a brain structure involved in the coordination, control and learning of movements, and elucidation of its function is an important issue. Japanese scholars have made seminal...