Differential expression of the chemokine receptors by the Th1and (2009)
T Cells, Junko Yamamoto, Yuichi Adachi, Yoichi Onoue, Yoko S. Adachi, Yoshie Okabe, ...
Th2-type effector populations within circulating CD4 �
Massive transcriptional start site analysis of human genes in hypoxia cells (2009)
Tsuchihara, Katsuya, Suzuki, Yutaka, Wakaguri, Hiroyuki, Irie, Takuma, Tanimoto, Kousuke, Hashimoto, Shin-ichi, ...
Combining our full-length cDNA method and the massively parallel sequencing technology, we developed a simple method to collect precise positional information of transcriptional start sites (TSSs)...
MachiBase: a Drosophila melanogaster 5'-end mRNA transcription database (2009)
Ahsan, Budrul, Saito, Taro L., Hashimoto, Shin-ichi, Muramatsu, Keigo, Tsuda, Manabu, Sasaki, Atsushi, ...
MachiBase (http://machibase.gi.k.u-tokyo.ac.jp/) provides a comprehensive and freely accessible resource regarding Drosophila melanogaster 5′-end mRNA transcription at different developmental...
UTGB/medaka: genomic resource database for medaka biology (2008)
Ahsan, Budrul, Kobayashi, Daisuke, Yamada, Tomoyuki, Kasahara, Masahiro, Sasaki, Shin, Saito, Taro L., ...
Medaka (Oryzias latipes) is a small egg-laying freshwater teleost native to East Asia that has become an excellent model system for developmental genetics and evolutionary biology. The draft medaka...
Guo, Zijin, Jang, Myoung Ho, Otani, Kazuhiro, Bai, Zhongbin, Umemoto, Eiji, Matsumoto, Masanori, ...
CD4+CD25+ regulatory T cells (Tregs) have been implicated in the suppression of pathogenic responses to both self- and non-self-antigens in the intestine. However, their precise properties and...
Kurachi, Makoto, Kakimi, Kazuhiro, Ueha, Satoshi, Matsushima, Kouji
Memory CD8+ T cells generated during an immune response are long lived and self-renewing, offering enhanced host protection against re-infection. However, how an antigen-specific population of memory...
Synovial autoreactive T cells in rheumatoid arthritis resist IDO-mediated inhibition (2006)
Ji, Fang, Wang, Yuan, Zhang, Yi, Zhang, Jingwu Z, ...
A hallmark of T cell-mediated autoimmunity is the persistence of autoreactive T cells. However, it remains to elucidate the manner in which synovial T cells are sustained in patients with rheumatoid...
Trans-basement membrane migration of human basophils: role of matrix metalloproteinase-9 (2006)
Suzukawa, Maho, Komiya, Akiko, Iikura, Motoyasu, Nagase, Hiroyuki, Yoshimura-Uchiyama, Chitose, Yamada, Hirokazu, ...
In allergic disorders, basophils migrate from the blood stream to inflamed tissue sites. Since trans-basement membrane migration is an important step for local basophil accumulation, we performed a...
Kurachi, Makoto, Kakimi, Kazuhiro, Ueha, Satoshi, Matsushima, Kouji
Memory CD8+ T cells generated during an immune response are long lived and self-renewing, offering enhanced host protection against re-infection. However, how an antigen-specific population of memory...
Trans-basement membrane migration of human basophils: role of matrix metalloproteinase-9 (2006)
Suzukawa, Maho, Komiya, Akiko, Iikura, Motoyasu, Nagase, Hiroyuki, Yoshimura-Uchiyama, Chitose, Yamada, Hirokazu, ...
In allergic disorders, basophils migrate from the blood stream to inflamed tissue sites. Since trans-basement membrane migration is an important step for local basophil accumulation, we performed a...
5'SAGE: 5'-end Serial Analysis of Gene Expression database (2005)
Kasai, Yasuhiro, Hashimoto, Shin-ichi, Yamada, Tomoyuki, Sese, Jun, Sugano, Sumio, Matsushima, Kouji, ...
To comprehensively identify transcription start sites and the frequencies of individual mRNAs in human cell libraries, a method of 5′ end Serial Analysis of Gene Expression (SAGE) was developed...
Tokuyama, Hirotake, Ueha, Satoshi, Kurachi, Makoto, Matsushima, Kouji, Moriyasu, Fuminori, Blumberg, Richard S., ...
Chemokine receptors CCR2, CCR5 and CXCR3 are involved in the regulation of macrophage- and T cell-mediated immune responses and in the migration and activation of these cells. In order to determine...
Tokuyama, Hirotake, Ueha, Satoshi, Kurachi, Makoto, Matsushima, Kouji, Moriyasu, Fuminori, Blumberg, Richard S., ...
Chemokine receptors CCR2, CCR5 and CXCR3 are involved in the regulation of macrophage- and T cell-mediated immune responses and in the migration and activation of these cells. In order to determine...
doi:10.1093/nar/gki085 5 0 SAGE: 5 0-end Serial Analysis of Gene Expression database (2004)
Yasuhiro Kasai, Shin-ichi Hashimoto, Tomoyuki Yamada, Jun Sese, Sumio Sugano, Kouji Matsushima, ...
To comprehensively identify transcription start sites and the frequencies of individual mRNAs in human cell libraries, a method of 5 0 end Serial Analysis of Gene Expression (SAGE) was developed...
Endocrine Disruptors (Environmental Estrogens) Enhance Autoantibody Production by B1 Cells (2004)
Yurino, Hideaki, Ishikawa, Sho, Sato, Taku, Akadegawa, Kenji, Ito, Toshihiro, Ueha, Satoshi, ...
Accumulating data suggest that endocrine disruptors affect not only the reproductive system, but also the immune system. We demonstrate here that endocrine disruptors including diethylstilbestrol...
Endocrine Disruptors (Environmental Estrogens) Enhance Autoantibody Production by B1 Cells (2004)
Yurino, Hideaki, Ishikawa, Sho, Sato, Taku, Akadegawa, Kenji, Ito, Toshihiro, Ueha, Satoshi, ...
Accumulating data suggest that endocrine disruptors affect not only the reproductive system, but also the immune system. We demonstrate here that endocrine disruptors including diethylstilbestrol...
Zhang, Yanyun, Yoneyama, Hiroyuki, Wang, Yong, Ishikawa, Sho, Hashimoto, Shin-ichi, Gao, Ji-Liang, ...
Background: Dendritic cells (DCs) play a central role in immune responses and may be useful adjuvants for tumor vaccine therapy. We previously reported that F4/80B220CD11c+ DC precursors...
Yoneyama, Hiroyuki, Matsuno, Kenjiro, Zhang, Yanyun, Nishiwaki, Tetsu, Kitabatake, Masahiro, Ueha, Satoshi, ...
Recruitment of dendritic cells (DCs) to lymph nodes (LNs) is pivotal to the establishment of immune response. Whereas DCs have been proven to undergo afferent lymphatic pathway to enter LNs from...
Monocyte chemoattractant protein-1: does it play a role in diabetic nephropathy? (2003)
Wada, Takashi, Yokoyama, Hitoshi, Matsushima, Kouji, Kobayashi, Ken-ichi
Toyoda, Nobuaki, Nagai, Shigenori, Terashima, Yuya, Motomura, Kazushi, Haino, Makoto, Hashimoto, Shin-ichi, ...
In the regulation of host defense responses such as inflammation and immunity, the secretory proteins, including membrane proteins, play central roles. Although many secretory proteins have been...
Toyoda, Nobuaki, Nagai, Shigenori, Terashima, Yuya, Motomura, Kazushi, Haino, Makoto, Hashimoto, Shin-ichi, ...
In the regulation of host defense responses such as inflammation and immunity, the secretory proteins, including membrane proteins, play central roles. Although many secretory proteins have been...
Onai, Nobuyuki, Kitabatake, Masahiro, Zhang, Yan-yun, Ishikawa, Hiromichi, Ishikawa, Sho, Matsushima, Kouji
Cryptopatches (CP) are murine gut anatomical sites for generating thymus‐independent intraepithelial T lymphocytes (IEL). However, it remains elusive how lympho‐hematopoietic progenitor...
p38 MAPK phosphorylation and NF-{kappa}B activation in human crescentic glomerulonephritis (2002)
Sakai, Norihiko, Wada, Takashi, Furuichi, Kengo, Iwata, Yasunori, Yoshimoto, Keiichi, Kitagawa, Kiyoki, ...
Background. p38 mitogen‐activated protein kinase (p38 MAPK) followed by the activation of NF‐κB participates in the intracellular signal transduction and production of...
Furuichi, Kengo, Wada, Takashi, Iwata, Yasunori, Sakai, Norihiko, Yoshimoto, Keiichi, Kobayashi, Ken-ichi, ...
Background. Various types of chemokines/cytokines play important roles in ischaemia/reperfusion injury in kidneys. However, the roles of p38 mitogen‐activated protein kinase...
Yokoyama, Hitoshi, Wada, Takashi, Kobayashi, Ken-ichi, Kuno, Kouji, Kurihara, Hiroki, Shindo, Takayuki, ...
Background. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)‐1 is distinguished from other a disintegrin and metalloproteinase molecules by the presence of...
Chemokines in renal diseases (2001)
Wada, Takashi, Yukoyama, Hitoshi, Matsushima, Kouji, Kobayashi, Kenichi, 和田, 隆志
The interaction of activated leukocytes and renal resident cells is thought to play a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of...
Comprehensive gene expression profile of human activated Th1- and Th2-polarized cells (2001)
Nagai, Shigenori, Hashimoto, Shin-ichi, Yamashita, Taro, Toyoda, Nobuaki, Satoh, Taku, Suzuki, Takuji, ...
In response to antigen stimulation, Th cells differentiate into two types of effector cells, Th1 and Th2. Th1 cells predominantly mediate cellular immunity, whereas Th2 cells induce humoral allergic...
Redistribution of selectin counter-ligands induced by cytokines (2000)
Nagata, Kisaburo, Tsuji, Tsutomu, Matsushima, Kouji, Hanai, Nobuo, Irimura, Tatsuro
Soluble recombinant (r) P-selectin and rP-selectin immobilized on plastic surfaces were tested for their capacity to activate neutrophils to produce superoxide anion. Soluble rP-selectin was...
Osawa, Yoshiaki, Hachiya, Misao, Araki, Shun-ichi, Kusama, Tomoko, Matsushima, Kouji, Aoki, Yoshiro, ...
We tested the effect of IL-1 on the expression of p21WAF1 in human embryonic fibroblasts WI38. Exposure to IL-1 caused induction of p21WAF1 protein in high-passage WI38 cells but not in early-passage...
Imai, Toshio, Nagira, Morio, Takagi, Shin, Kakizaki, Mayumi, Nishimura, Miyuki, Wang, Jianbin, ...
Helper T cells are classified into Th1 and Th2 subsets based on their profiles of cytokine production. Th1 cells are involved in cell-mediated immunity, whereas Th2 cells induce humoral responses....
Th1-derived cytokine IFN-{gamma} is a potent inhibitor of eotaxin synthesis in vitro (1999)
Miyamasu, Misato, Yamaguchi, Masao, Nakajima, Toshiharu, Misaki, Yoshikata, Morita, Yutaka, Matsushima, Kouji, ...
Eotaxin potentially plays an integral role in tissue eosinophilia. Inasmuch as Th2-derived cytokine IL-4 has been shown to stimulate eotaxin generation, we investigated here the effect of Th1-derived...
Watanabe, Shun-ichi, Mukaida, Naofumi, Ikeda, Naoki, Akiyama, Mariko, Harada, Akihisa, Nakanishi, Isao, ...
Septic shock remains a serious disorder associated with high mortality. Accumulating evidence indicates that TNF is a major and essential mediator of endotoxin shock. We report here that...
Kuno, Kouji, Sukegawa, Kazuko, Ishikawa, Yuji, Oril, Tadao, Matsushima, Kouji
A recent report has suggested that tumor necrosis factor (TNF) utilizes acid sphingomyelinase (SMase) pathway to activate NFkB (Schutze et al. 1992. Cell 71:765). To directly investigate the role of...
Nomura, Hideki, Nielsen, Bent W., Matsushima, Kouji, Arai, K.
Several cDNA clones encoding receptors for leukocyte chemoattractants, including IL-8, C5a, N-formyl peptides (FP), and platelet-activating factor, have been isolated in the past 3 years. The primary...
Harada, Akihisa, Sekido, Nobuaki, Kuno, Kouji, Aklyama, Mariko, Kasahara, Tadashi, Nakanishi, Isao, ...
In order to establish the pathophyslological roles of IL-8, rabbit IL-8 was expressed in Escherichia coli and purified to homogeneity by sequential chromatography on heparin agarose, CM-HPLC, and...
Calcium-Dependent Binding of Phosphorylated Human Pre Interleukin 1{alpha} to Phospholipids (1990)
Kobayashi, Yoshiro, Oppenheim, Joost J., Matsushima, Kouji
The effect of phosphorylation of pre interleukin la (IL la) on its association with various phospholipids was investigated. We prepared genetically engineered truncated human pre IL la (residues 64...
Production and Characterization of Recombinant Human Neutrophil Chemotactic Factor (1989)
Furuta, Ryuji, Yamagishi, Junichi, Kotani, Hirotada, Sakamoto, Fumiko, Fukui, Toshikazu, Matsui, Yukiharu, ...
A putative mature human neutrophil chemotactic factor (NCF) corresponding to the C-terminal 72 amino acids of its precursor was directly produced in Escherichia coli by recombinant DNA technology....
Nagasawa, Takashi, Nakajima, Toshihiro, Tachibana, Kazunobu, Iizasa, Hisashi, Bleul, Conrad C., Yoshie, Osamu, ...
Pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 (PBSF/SDF-1) is a member of the CXC group of chemokines that is initially identified as a bone marrow stromal cell-derived factor...
Sar, Borann, Oishi, Kazunori, Wada, Akihiro, Hirayama, Toshiya, Matsushima, Kouji, Nagatake, Tsuyoshi
We have recently reported that nitrite reductase, a bifunctional enzyme located in the periplasmic space of Pseudomonas aeruginosa, could induce interleukin-8 (IL-8) generation in a variety of...
Mori, Naoki, Oishi, Kazunori, Sar, Borann, Mukaida, Naofumi, Nagatake, Tsuyoshi, Matsushima, Kouji, ...
Persistent infection with Pseudomonas aeruginosa increases interleukin-8 (IL-8) levels and causes dense neutrophil infiltrations in the airways of patients with chronic airway diseases. Recently, we...
Amano, Hideaki, Yamamoto, Hidefumi, Senba, Masachika, Oishi, Kazunori, Suzuki, Shoichi, Fukushima, Kenichi, ...
To elucidate the mechanism of the high incidence of lower respiratory tract infections in patients with diabetes mellitus, we investigated the kinetics of production of macrophage inflammatory...
Tsuchihashi, Yoshiko, Oishi, Kazunori, Yoshimine, Hiroyuki, Suzuki, Shoichi, Kumatori, Atsushi, Sunazuka, Toshiaki, ...
A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest...
Yamaryo, Takeshi, Oishi, Kazunori, Yoshimine, Hiroyuki, Tsuchihashi, Yoshiko, Matsushima, Kouji, Nagatake, Tsuyoshi
An inflammation of the airway of patients with diffuse panbronchiolitis (DPB), is characterized by dense neutrophil infiltration. Resolution of the inflammation can be achieved by the removal of...
Shindo, Takayuki, Kurihara, Hiroki, Kuno, Kouji, Yokoyama, Hitoshi, Wada, Takashi, Kurihara, Yukiko, ...
A disintegrin and metalloproteinase (ADAM) represents a protein family possessing both metalloproteinase and disintegrin domains. ADAMTS-1, an ADAM family member cloned from cachexigenic colon...
Toyoda , Nobuaki, Nagai, Shigenori, Terashima, Yuya, Motomura, Kazushi, Haino, Makoto, Hashimoto, Shin-ichi, ...
In the regulation of host defense responses such as inflammation and immunity, the secretory proteins, including membrane proteins, play central roles. Although many secretory proteins have been...
Betsuyaku, Tomoko, Liu, Fulu, Senior, Robert M., Haug, Jeffery S., Brown, Eric J., Jones, Samuel L., ...
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that is widely used to treat neutropenia. In addition to stimulating polymorphonuclear neutrophil (PMN) production,...
Murai, Masako, Yoneyama, Hiroyuki, Harada, Akihisa, Yi, Zhang, Vestergaard, Christian, Guo, Baoyu, ...
We examined the molecular pathogenesis of graft-versus-host disease–associated (GVHD-associated) liver injury in mice, focusing on the role of chemokines. At the second week after cell transfer in...
Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis–like lesions
Vestergaard, Christian, Yoneyama, Hiroyuki, Murai, Masako, Nakamura, Kohichiro, Tamaki, Kunihiko, Terashima, Yuya, ...
We have examined the expression of chemokines and their receptors in the atopic dermatitis–like (AD-like) lesions of NC/Nga mice. Such lesions develop when the mice are kept in conventional...
5′SAGE: 5′-end Serial Analysis of Gene Expression database
Kasai, Yasuhiro, Hashimoto, Shin-ichi, Yamada, Tomoyuki, Sese, Jun, Sugano, Sumio, Matsushima, Kouji, ...
To comprehensively identify transcription start sites and the frequencies of individual mRNAs in human cell libraries, a method of 5′ end Serial Analysis of Gene Expression (SAGE) was developed...
Wada, Takashi, Yukoyama, Hitoshi, Matsushima, Kouji, Kobayashi, Ken-ichi
The interaction of activated leukocytes and renal resident cells is thought to play a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of...
Nagasawa, Takashi, Nakajima, Toshihiro, Tachibana, Kazunobu, Iizasa, Hisashi, Bleul, Conrad C., Yoshie, Osamu, ...
Pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 (PBSF/SDF-1) is a member of the CXC group of chemokines that is initially identified as a bone marrow stromal cell-derived factor...
Sar, Borann, Oishi, Kazunori, Wada, Akihiro, Hirayama, Toshiya, Matsushima, Kouji, Nagatake, Tsuyoshi
We have recently reported that nitrite reductase, a bifunctional enzyme located in the periplasmic space of Pseudomonas aeruginosa, could induce interleukin-8 (IL-8) generation in a variety of...
Mori, Naoki, Oishi, Kazunori, Sar, Borann, Mukaida, Naofumi, Nagatake, Tsuyoshi, Matsushima, Kouji, ...
Persistent infection with Pseudomonas aeruginosa increases interleukin-8 (IL-8) levels and causes dense neutrophil infiltrations in the airways of patients with chronic airway diseases. Recently, we...
Amano, Hideaki, Yamamoto, Hidefumi, Senba, Masachika, Oishi, Kazunori, Suzuki, Shoichi, Fukushima, Kenichi, ...
To elucidate the mechanism of the high incidence of lower respiratory tract infections in patients with diabetes mellitus, we investigated the kinetics of production of macrophage inflammatory...
Tsuchihashi, Yoshiko, Oishi, Kazunori, Yoshimine, Hiroyuki, Suzuki, Shoichi, Kumatori, Atsushi, Sunazuka, Toshiaki, ...
A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest...
Yamaryo, Takeshi, Oishi, Kazunori, Yoshimine, Hiroyuki, Tsuchihashi, Yoshiko, Matsushima, Kouji, Nagatake, Tsuyoshi
An inflammation of the airway of patients with diffuse panbronchiolitis (DPB), is characterized by dense neutrophil infiltration. Resolution of the inflammation can be achieved by the removal of...
Shindo, Takayuki, Kurihara, Hiroki, Kuno, Kouji, Yokoyama, Hitoshi, Wada, Takashi, Kurihara, Yukiko, ...
A disintegrin and metalloproteinase (ADAM) represents a protein family possessing both metalloproteinase and disintegrin domains. ADAMTS-1, an ADAM family member cloned from cachexigenic colon...
Toyoda , Nobuaki, Nagai, Shigenori, Terashima, Yuya, Motomura, Kazushi, Haino, Makoto, Hashimoto, Shin-ichi, ...
In the regulation of host defense responses such as inflammation and immunity, the secretory proteins, including membrane proteins, play central roles. Although many secretory proteins have been...
Betsuyaku, Tomoko, Liu, Fulu, Senior, Robert M., Haug, Jeffery S., Brown, Eric J., Jones, Samuel L., ...
Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that is widely used to treat neutropenia. In addition to stimulating polymorphonuclear neutrophil (PMN) production,...
Murai, Masako, Yoneyama, Hiroyuki, Harada, Akihisa, Yi, Zhang, Vestergaard, Christian, Guo, Baoyu, ...
We examined the molecular pathogenesis of graft-versus-host disease–associated (GVHD-associated) liver injury in mice, focusing on the role of chemokines. At the second week after cell transfer in...
Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis–like lesions
Vestergaard, Christian, Yoneyama, Hiroyuki, Murai, Masako, Nakamura, Kohichiro, Tamaki, Kunihiko, Terashima, Yuya, ...
We have examined the expression of chemokines and their receptors in the atopic dermatitis–like (AD-like) lesions of NC/Nga mice. Such lesions develop when the mice are kept in conventional...
5′SAGE: 5′-end Serial Analysis of Gene Expression database
Kasai, Yasuhiro, Hashimoto, Shin-ichi, Yamada, Tomoyuki, Sese, Jun, Sugano, Sumio, Matsushima, Kouji, ...
To comprehensively identify transcription start sites and the frequencies of individual mRNAs in human cell libraries, a method of 5′ end Serial Analysis of Gene Expression (SAGE) was developed...
Wada, Takashi, Yukoyama, Hitoshi, Matsushima, Kouji, Kobayashi, Kenichi, 和田, 隆志
The interaction of activated leukocytes and renal resident cells is thought to play a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of...
Wada, Takashi, Yukoyama, Hitoshi, Matsushima, Kouji, Kobayashi, Ken-ichi
The interaction of activated leukocytes and renal resident cells is thought to play a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of...
Wada, Takashi, Yukoyama, Hitoshi, Matsushima, Kouji, Kobayashi, Kenichi, 和田, 隆志
The interaction of activated leukocytes and renal resident cells is thought to play a crucial role in the pathogenesis of renal diseases. Recent investigations of the pathophysiological roles of...
Kamohara, Hidenobu, Matsuyama, Wataru, Shimozato, Osamu, Abe, Koichiro, Galligan, Carole, Hashimoto, Shin-Ichi, ...
Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily, which is capable of inducing apoptosis in many cell types, including tumour and...
Sakai, Norihiko, Wada, Takashi, Yokoyama, Hitoshi, Lipp, Martin, Ueha, Satoshi, Matsushima, Kouji, ...
Fibrocytes are a distinct population of bloodborne cells that share markers of leukocytes as well as mesenchymal cells. We hypothesized that CCR7-positive fibrocytes migrate into the kidney in...
Blockade of CCR2 Ameliorates Progressive Fibrosis in Kidney
Kitagawa, Kiyoki, Wada, Takashi, Furuichi, Kengo, Hashimoto, Hiroyuki, Ishiwata, Yoshiro, Asano, Masahide, ...
Fibrosis is a hallmark of progressive organ diseases. Monocyte chemoattractant protein (MCP)-1, also termed as macrophage chemotactic and activating factor (MCAF/CCL2) and its receptor, CCR2 are...
Nishiwaki, Tetsu, Yoneyama, Hiroyuki, Eishi, Yoshinobu, Matsuo, Naoki, Tatsumi, Koichiro, Kimura, Hiroshi, ...
Although many cases of sarcoidosis are self-limiting with spontaneous remission, uncontrolled pulmonary granulomatosis with fibrosis produces intolerable long-term respiratory symptoms in a minority...
Katou, Fuminori, Ohtani, Haruo, Nakayama, Takashi, Ono, Katsuhiko, Matsushima, Kouji, Saaristo, Anne, ...
Our previous study demonstrated formation of T cell-dendritic cell (DC) clusters in inflamed dermis of intraorally autotransplanted skin flaps. Such T cell-DC clusters are supposed to be important...
Ishida, Yuko, Kimura, Akihiko, Kondo, Toshikazu, Hayashi, Takahito, Ueno, Masaya, Takakura, Nobuyuki, ...
We investigated the pathogenic roles of CC chemokine ligand (CCL)3 and its receptors, CC chemokine receptor (CCR)1 and CCR5, in bleomycin (BLM)-induced pulmonary fibrosis (PF). An intratracheal...
Fujimura, Masaki, Myou, Shigeharu, Nomura, Masaharu, Matsuda, Tamotsu, Harada, Akihisa, Mukaida, Naofumi, ...
Although repeated intranasal administration of interleukin-8 (IL-8) causes bronchial hyperresponsiveness (BHR) mediated via thromboxane A2 (TXA2) and airway neutrophil accumulation in guinea-pigs,...
Endo, Yasuo, Tabata, Takayoshi, Kuroda, Hiroshi, Tadano, Takeshi, Matsushima, Kouji, Watanabe, Makoto
In normal non-exercised skeletal muscles in mice, the activity of histidine decarboxylase (HDC), the enzyme which forms histamine, was very low.HDC activity in the quadriceps femoris muscle was...
UTGB/medaka: genomic resource database for medaka biology
Ahsan, Budrul, Kobayashi, Daisuke, Yamada, Tomoyuki, Kasahara, Masahiro, Sasaki, Shin, Saito, Taro L., ...
Medaka (Oryzias latipes) is a small egg-laying freshwater teleost native to East Asia that has become an excellent model system for developmental genetics and evolutionary biology. The draft medaka...
Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs
Yoneyama, Hiroyuki, Matsuno, Kenjiro, Toda, Etsuko, Nishiwaki, Tetsu, Matsuo, Naoki, Nakano, Akiko, ...
Antiviral cell–mediated immunity is initiated by the dendritic cell (DC) network in lymph nodes (LNs). Plasmacytoid DCs (pDCs) are known to migrate to inflamed LNs and produce interferon (IFN)-α,...
Ishikawa, Sho, Sato, Taku, Abe, Masaaki, Nagai, Shigenori, Onai, Nobuyuki, Yoneyama, Hiroyuki, ...
We observed here that the expression of B lymphocyte chemokine (BLC/CXCL13) was markedly enhanced in the thymus and kidney in aged (NZB × NZW)F1 (BWF1) mice developing lupus nephritis, but not in...
Yoneyama, Hiroyuki, Narumi, Shosaku, Zhang, Yanyun, Murai, Masako, Baggiolini, Marco, Lanzavecchia, Antonio, ...
Various immune diseases are considered to be regulated by the balance of T helper (Th)1 and Th2 subsets. Although Th lymphocytes are believed to be generated in draining lymph nodes (LNs), in vivo Th...
Yoneyama, Hiroyuki, Matsuno, Kenjiro, Zhang, Yanyun, Murai, Masako, Itakura, Meiji, Ishikawa, Sho, ...
We have studied the recruitment and roles of distinct dendritic cell (DC) precursors from the circulation into Propionibacterium acnes–induced granulomas in mouse liver. During infection,...
The α Chemokine, Interleukin 8, Inhibits the Antiviral Action of Interferon α
Khabar, Khalid S.A., Al-Zoghaibi, Fahad, Al-Ahdal, Mohammed N., Murayama, Tsugiya, Dhalla, Mohammed, Mukaida, Naofumi, ...
Interferon (IFN) exhibits a potent antiviral activity in vitro and plays a major role in the early defense against viruses. Like IFN, the proinflammatory chemokine, interleukin (IL)-8, is induced by...
High-Resolution Analysis of the 5′-End Transcriptome Using a Next Generation DNA Sequencer
Hashimoto, Shin-ichi, Qu, Wei, Ahsan, Budrul, Ogoshi, Katsumi, Sasaki, Atsushi, Nakatani, Yoichiro, ...
Massively parallel, tag-based sequencing systems, such as the SOLiD system, hold the promise of revolutionizing the study of whole genome gene expression due to the number of data points that can be...
Massive transcriptional start site analysis of human genes in hypoxia cells
Tsuchihara, Katsuya, Suzuki, Yutaka, Wakaguri, Hiroyuki, Irie, Takuma, Tanimoto, Kousuke, Hashimoto, Shin-ichi, ...
Combining our full-length cDNA method and the massively parallel sequencing technology, we developed a simple method to collect precise positional information of transcriptional start sites (TSSs)...
MachiBase: a Drosophila melanogaster 5′-end mRNA transcription database
Ahsan, Budrul, Saito, Taro L., Hashimoto, Shin-ichi, Muramatsu, Keigo, Tsuda, Manabu, Sasaki, Atsushi, ...
MachiBase (http://machibase.gi.k.u-tokyo.ac.jp/) provides a comprehensive and freely accessible resource regarding Drosophila melanogaster 5′-end mRNA transcription at different developmental...
Abe, Jun, Ueha, Satoshi, Suzuki, Jun, Tokano, Yoshiaki, Matsushima, Kouji, Ishikawa, Sho
Foxp3+ CD4+ regulatory T (Treg) cells play a pivotal role in the maintenance of dominant self tolerance. Understanding how the failures of immune control by Treg cells are involved in autoimmune...