Scientific Commons: Krishna K. Murthy

Graphic display of cockpit instruments for flight simulation (1991)

A generalised software to visualise the behaviour of an aircraft in simulated light, through cockpit instruments has been designed and developed . The display is achieved by incorporating the...

Photoelectrochemical fabrication of stainless steel filter elements (1986)

Dasannacharya, BS, Murthy, Krishna K, Rajagopal, Indira, Rajagopalan, SR

Precision fabrication of stainless steel filters is described. Controlled depth (10 mu m) of metal removal was achieved by an anodic dissolution technique. In addition this technique gave a very...

Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex

Wang, Chang Yi, Sawyer, Lynette S. W., Murthy, Krishna K., Fang, Xinde, Walfield, Alan M., Ye, John, ...

mAb B4 is a monoclonal antibody directed against HIV receptor complex. The antibody had broad neutralizing activity against HIV and provided postexposure prophylaxis to hu–peripheral blood...

The Resistance of Retroviral Vectors Produced from Human Cells to Serum Inactivation In Vivo and In Vitro Is Primate Species Dependent

DePolo, Nicholas J., Harkleroad, Cataline E., Bodner, Mordechai, Watt, Andrew T., Anderson, Carol G., Greengard, Judith S., ...

The ability to deliver genes as therapeutics requires an understanding of the vector pharmacokinetics similar to that required for conventional drugs. A first question is the half-life of the vector...

Increased Virus Replication and Virulence after Serial Passage of Human Immunodeficiency Virus Type 2 in Baboons

Locher, Christopher P., Witt, Stephanie A., Herndier, Brian G., Abbey, Nancy W., Tenner-Racz, Klara, Racz, Paul, ...

Similar to human immunodeficiency virus type 1 (HIV-1) infection of humans, the natural history of HIV-2 infection in baboons (Papio cynocephalus) is a slow and chronic disease that generally takes...

The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity

Thomson, Michael, Nascimbeni, Michelina, Havert, Michael B., Major, Marian, Gonzales, Sophia, Alter, Harvey, ...

Clearance of hepatitis C virus (HCV) infection in humans and chimpanzees is thought to be associated with the induction of strong T-cell responses. We studied four chimpanzees infected with HCV...

Vaccine-Induced Immunity in Baboons by Using DNA and Replication-Incompetent Adenovirus Type 5 Vectors Expressing a Human Immunodeficiency Virus Type 1 gag Gene

Casimiro, Danilo R., Tang, Aimin, Chen, Ling, Fu, Tong-Ming, Evans, Robert K., Davies, Mary-Ellen, ...

The cellular immunogenicity of formulated plasmid DNA and replication-defective human adenovirus serotype 5 (Ad5) vaccine vectors expressing a codon-optimized human immunodeficiency virus type 1 gag...

Replicating Rather than Nonreplicating Adenovirus-Human Immunodeficiency Virus Recombinant Vaccines Are Better at Eliciting Potent Cellular Immunity and Priming High-Titer Antibodies

Peng, Bo, Wang, Liqun Rejean, Gómez-Román, Victor Raúl, Davis-Warren, Alberta, Montefiori, David C., Kalyanaraman, V. S., ...

A major challenge in combating the human immunodeficiency virus (HIV) epidemic is the development of vaccines capable of inducing potent, persistent cellular immunity and broadly reactive...

Transmission of Simian Immunodeficiency Virus SIVcpz and the Evolution of Infection in the Presence and Absence of Concurrent Human Immunodeficiency Virus Type 1 Infection in Chimpanzees

Heeney, Jonathan L., Rutjens, Erik, Verschoor, Ernst J., Niphuis, Henk, Ten Haaft, Peter, Rouse, Scott, ...

Current data suggest that the human immunodeficiency virus type 1 (HIV-1) epidemic arose by transmission of simian immunodeficiency virus (SIV) SIVcpz from a subspecies of common chimpanzees (Pan...