Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells (2005)
Lina E. Tze, Brian R. Schram, Kong-Peng Lam, Kristin A. Hogquist, Keli L. Hippen, Jiabin Liu, ...
Gene rearrangement is a hallmark of B cell maturation. By interrupting basal cell signaling through the rearranged IgM receptor, immature B cells "back-differentiate" to an earlier stage in their...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells (2005)
Lina E. Tze, Brian R. Schram, Kong-Peng Lam, Kristin A. Hogquist, Keli L. Hippen, Jiabin Liu, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
Puls, Kirsten L., Hogquist, Kristin A., Reilly, Nancy, Wright, Mark D.
The molecular mechanisms that govern the survival, maturation and export of thymocytes are the subject of intense study, and candidates for involvement in these processes might be identified by their...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
Tze, Lina E, Schram, Brian R, Lam, Kong-Peng, Hogquist, Kristin A, Hippen, Keli L, Liu, Jiabin, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
A requirement for sustained ERK signaling during thymocyte positive selection in vivo
McNeil, Lisa K., Starr, Timothy K., Hogquist, Kristin A.
It is unknown how the contrasting events of positive and negative selection can lead to the distinct biological outcomes of life or death. An increasing body of evidence suggests that the duration of...
Langerhans Cells Activate Naive Self-Antigen-Specific CD8 T Cells in the Steady State
Mayerova, Dita, Parke, Evan A., Bursch, Laura S., Odumade, Oludare A., Hogquist, Kristin A.
TCR transgenic mice that express a peptide antigen in keratinocytes develop a lethal CD8 T cell-dependent autoimmune disease. We employed an adoptive transfer system to understand this disease and...
Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells
Tze, Lina E, Schram, Brian R, Lam, Kong-Peng, Hogquist, Kristin A, Hippen, Keli L, Liu, Jiabin, ...
In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B...
A requirement for sustained ERK signaling during thymocyte positive selection in vivo
McNeil, Lisa K., Starr, Timothy K., Hogquist, Kristin A.
It is unknown how the contrasting events of positive and negative selection can lead to the distinct biological outcomes of life or death. An increasing body of evidence suggests that the duration of...
The timing of TCRα expression critically influences T cell development and selection
Baldwin, Troy A., Sandau, Michelle M., Jameson, Stephen C., Hogquist, Kristin A.
Sequential rearrangement of the T cell receptor for antigen (TCR) β and α chains is a hallmark of thymocyte development. This temporal control is lost in TCR transgenics because the α chain is...
Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells
Davey, Gayle M., Schober, Sonya L., Endrizzi, Bart T., Dutcher, Angela K., Jameson, Stephen C., Hogquist, Kristin A.
During T cell development, thymocytes which are tolerant to self-peptides but reactive to foreign peptides are selected. The current model for thymocyte selection proposes that self-peptide–major...
McCaughtry, Tom M., Wilken, Matthew S., Hogquist, Kristin A.
Conventional αβ T cell precursors undergo positive selection in the thymic cortex. When this is successful, they migrate to the medulla and are exposed to tissue-specific antigens (TSA) for...
Identification of a novel population of Langerin+ dendritic cells
Bursch, Laura S., Wang, Liangchun, Igyarto, Botond, Kissenpfennig, Adrien, Malissen, Bernard, Kaplan, Daniel H., ...
Langerhans cells (LCs) are antigen-presenting cells that reside in the epidermis of the skin and traffic to lymph nodes (LNs). The general role of these cells in skin immune responses is not clear...
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
McCaughtry, Tom M., Baldwin, Troy A., Wilken, Matthew S., Hogquist, Kristin A.
The thymic medulla is generally held to be a specialized environment for negative selection. However, many self-reactive thymocytes first encounter ubiquitous self-antigens in the cortex. Cortical...