Pin1 modulates the structure and function of human RNA polymerase II (2003)
Xu, Yu-Xin, Hirose, Yutaka, Zhou, Xiao Zhen, Lu, Kun Ping, Manley, James L.
The C-terminal domain of the RNA polymerase (RNAP) II largest subunit (CTD) plays critical roles both in transcription of mRNA precursors and in the processing reactions needed to form mature mRNAs....
Pin1 modulates the structure and function of human RNA polymerase II (2003)
Xu, Yu-Xin, Hirose, Yutaka, Zhou, Xiao Zhen, Lu, Kun Ping, Manley, James L.
The C-terminal domain of the RNA polymerase (RNAP) II largest subunit (CTD) plays critical roles both in transcription of mRNA precursors and in the processing reactions needed to form mature mRNAs....
Gerez, Lisya, Mohrmann, Karin, Van Raak, Marcel, Jongeneelen, Mandy, Zhou, Xiao Zhen, Lu, Kun Ping, ...
Transport through the endocytic pathway is inhibited during mitosis. The mechanism responsible for this inhibition is not understood. Rab4 might be one of the proteins involved as it regulates...
Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53
Lee, Sam W., Fang, Li, Igarashi, Makoto, Ouchi, Toru, Lu, Kun Ping, Aaronson, Stuart A.
The p53 tumor suppressor gene can inhibit proliferation transiently, induce permanent cell-cycle arrest/senescence, or cause apoptosis depending on the cellular context. The mitogen-activated protein...
Shen, Minhui, Haggblom, Candy, Vogt, Marguerite, Hunter, Tony, Lu, Kun Ping
Telomeres are essential for preserving chromosome integrity during the cell cycle and have been specifically implicated in mitotic progression, but little is known about the signaling molecule(s)...
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes
Liou, Yih-Cherng, Ryo, Akihide, Huang, Han-Kuei, Lu, Pei-Jung, Bronson, Roderick, Fujimori, Fumihiro, ...
Phosphorylation of proteins on serine/threonine residues preceding proline is a key signaling mechanism. The conformation and function of a subset of these phosphorylated proteins is regulated by the...
Wulf, Gerburg M., Ryo, Akihide, Wulf, Gerald G., Lee, Sam W., Niu, Tianhua, Petkova, Victoria, ...
Phosphorylation on serines or threonines preceding proline (Ser/Thr-Pro) is a major signaling mechanism. The conformation of a subset of phosphorylated Ser/Thr-Pro motifs is regulated by the prolyl...
PIN1 Is an E2F Target Gene Essential for Neu/Ras-Induced Transformation of Mammary Epithelial Cells
Ryo, Akihide, Liou, Yih-Cherng, Wulf, Gerburg, Nakamura, Masafumi, Lee, Sam W., Lu, Kun Ping
Oncogenes Neu/HER2/ErbB2 and Ras can induce mammary tumorigenesis via upregulation of cyclin D1. One major regulatory mechanism in these oncogenic signaling pathways is phosphorylation of serines or...
The prolyl isomerase Pin1 in breast development and cancer
Wulf, Gerburg, Ryo, Akihide, Liou, Yih-Cherng, Lu, Kun Ping
The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is...
Pin1 modulates the structure and function of human RNA polymerase II
Xu, Yu-Xin, Hirose, Yutaka, Zhou, Xiao Zhen, Lu, Kun Ping, Manley, James L.
The C-terminal domain of the RNA polymerase (RNAP) II largest subunit (CTD) plays critical roles both in transcription of mRNA precursors and in the processing reactions needed to form mature mRNAs....
Shen, Minhui, Stukenberg, P. Todd, Kirschner, Marc W., Lu, Kun Ping
Phosphorylation of mitotic proteins on the Ser/Thr-Pro motifs has been shown to play an important role in regulating mitotic progression. Pin1 is a novel essential peptidyl–prolyl isomerase...
Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis
Wulf, Gerburg, Garg, Priti, Liou, Yih-Cherng, Iglehart, Dirk, Lu, Kun Ping
Phosphorylation on certain Ser/Thr-Pro motifs is a major oncogenic mechanism. The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1....
Chen, Shao-Yong, Wulf, Gerburg, Zhou, Xiao Zhen, Rubin, Mark A., Lu, Kun Ping, Balk, Steven P.
Androgen receptor (AR) interacts with β-catenin and can suppress its coactivation of T cell factor 4 (Tcf4) in prostate cancer (PCa) cells. Pin1 is a peptidyl-prolyl cis/trans isomerase that...
Suizu, Futoshi, Ryo, Akihide, Wulf, Gerburg, Lim, Jormay, Lu, Kun Ping
Phosphorylation on Ser/Thr-Pro motifs is a major mechanism regulating many events involved in cell proliferation and transformation, including centrosome duplication, whose defects have been...
Gerez, Lisya, Mohrmann, Karin, Van Raak, Marcel, Jongeneelen, Mandy, Zhou, Xiao Zhen, Lu, Kun Ping, ...
Transport through the endocytic pathway is inhibited during mitosis. The mechanism responsible for this inhibition is not understood. Rab4 might be one of the proteins involved as it regulates...
Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53
Lee, Sam W., Fang, Li, Igarashi, Makoto, Ouchi, Toru, Lu, Kun Ping, Aaronson, Stuart A.
The p53 tumor suppressor gene can inhibit proliferation transiently, induce permanent cell-cycle arrest/senescence, or cause apoptosis depending on the cellular context. The mitogen-activated protein...
Shen, Minhui, Haggblom, Candy, Vogt, Marguerite, Hunter, Tony, Lu, Kun Ping
Telomeres are essential for preserving chromosome integrity during the cell cycle and have been specifically implicated in mitotic progression, but little is known about the signaling molecule(s)...
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes
Liou, Yih-Cherng, Ryo, Akihide, Huang, Han-Kuei, Lu, Pei-Jung, Bronson, Roderick, Fujimori, Fumihiro, ...
Phosphorylation of proteins on serine/threonine residues preceding proline is a key signaling mechanism. The conformation and function of a subset of these phosphorylated proteins is regulated by the...
Wulf, Gerburg M., Ryo, Akihide, Wulf, Gerald G., Lee, Sam W., Niu, Tianhua, Petkova, Victoria, ...
Phosphorylation on serines or threonines preceding proline (Ser/Thr-Pro) is a major signaling mechanism. The conformation of a subset of phosphorylated Ser/Thr-Pro motifs is regulated by the prolyl...
PIN1 Is an E2F Target Gene Essential for Neu/Ras-Induced Transformation of Mammary Epithelial Cells
Ryo, Akihide, Liou, Yih-Cherng, Wulf, Gerburg, Nakamura, Masafumi, Lee, Sam W., Lu, Kun Ping
Oncogenes Neu/HER2/ErbB2 and Ras can induce mammary tumorigenesis via upregulation of cyclin D1. One major regulatory mechanism in these oncogenic signaling pathways is phosphorylation of serines or...
The prolyl isomerase Pin1 in breast development and cancer
Wulf, Gerburg, Ryo, Akihide, Liou, Yih-Cherng, Lu, Kun Ping
The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is...
Pin1 modulates the structure and function of human RNA polymerase II
Xu, Yu-Xin, Hirose, Yutaka, Zhou, Xiao Zhen, Lu, Kun Ping, Manley, James L.
The C-terminal domain of the RNA polymerase (RNAP) II largest subunit (CTD) plays critical roles both in transcription of mRNA precursors and in the processing reactions needed to form mature mRNAs....
Shen, Minhui, Stukenberg, P. Todd, Kirschner, Marc W., Lu, Kun Ping
Phosphorylation of mitotic proteins on the Ser/Thr-Pro motifs has been shown to play an important role in regulating mitotic progression. Pin1 is a novel essential peptidyl–prolyl isomerase...
Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis
Wulf, Gerburg, Garg, Priti, Liou, Yih-Cherng, Iglehart, Dirk, Lu, Kun Ping
Phosphorylation on certain Ser/Thr-Pro motifs is a major oncogenic mechanism. The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1....
Chen, Shao-Yong, Wulf, Gerburg, Zhou, Xiao Zhen, Rubin, Mark A., Lu, Kun Ping, Balk, Steven P.
Androgen receptor (AR) interacts with β-catenin and can suppress its coactivation of T cell factor 4 (Tcf4) in prostate cancer (PCa) cells. Pin1 is a peptidyl-prolyl cis/trans isomerase that...
Suizu, Futoshi, Ryo, Akihide, Wulf, Gerburg, Lim, Jormay, Lu, Kun Ping
Phosphorylation on Ser/Thr-Pro motifs is a major mechanism regulating many events involved in cell proliferation and transformation, including centrosome duplication, whose defects have been...
Prevalent Overexpression of Prolyl Isomerase Pin1 in Human Cancers
Bao, Lere, Kimzey, Amy, Sauter, Guido, Sowadski, Janusz M., Lu, Kun Ping, Wang, Da-Gong
Phosphorylation of proteins on serine or threonine residues preceding proline (pSer/Thr-Pro) is a major regulatory mechanism in cell proliferation and transformation. Interestingly, the pSer/Thr-Pro...
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy
Lim, Jormay, Balastik, Martin, Lee, Tae Ho, Nakamura, Kazuhiro, Liou, Yih-Cherng, Sun, Anyang, ...
Tau pathology is a hallmark of many neurodegenerative diseases including Alzheimer disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). Genetic tau mutations...
Lam, Prudence B, Burga, Laura N, Wu, Bryan P, Hofstatter, Erin W, Lu, Kun Ping, Wulf, Gerburg M
Overexpression of HER-2/Neu occurs in about 25–30% of breast cancer patients and is indicative of poor prognosis. While Her2/Neu overexpression is primarily a result of erbB2 amplification, it has...
Balastik, Martin, Ferraguti, Francesco, Lee, Tae Ho, Alvarez-Bolado, Gonzalo, Lu, Kun Ping, ...
TRIM RING finger proteins have been shown to play an important role in cancerogenesis, in the pathogenesis of some human hereditary disorders, and in the defense against viral infection, but the...
Relative Resistance of Cdk5-phosphorylated CRMP2 to Dephosphorylation*S⃞
Cole, Adam R., Soutar, Marc P. M., Rembutsu, Makoto, Van Aalten, Lidy, Hastie, C. James, Mclauchlan, Hilary, ...
Collapsin response mediator protein 2 (CRMP2) binds to microtubules and regulates axon outgrowth in neurons. This action is regulated by sequential phosphorylation by the kinases cyclin-dependent...