Expression profiling identifies genes involved in emphysema severity (2009)
Francis, Santiyagu, Larsen, Jill E, Pavey, Sandra J, Bowman, Rayleen V, Hayward, Nicholas K, Fong, Kwun M, ...
Abstract Chronic obstructive pulmonary disease (COPD) is a major public health problem. The aim of this study was to identify genes involved in emphysema severity in COPD patients. Gene expression...
Meta- and Pooled Analysis of GSTP1 Polymorphism and Lung Cancer: A HuGE-GSEC Review (2009)
Cote, Michele L., Chen, Wei, Smith, Daryn W., Benhamou, Simone, Bouchardy, Christine, Butkiewicz, Dorota, ...
Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic...
Toyooka, Shinichi, Matsuo, Keitaro, Shigematsu, Hisayuki, Kosaka, Takayuki, Tokumo, Masaki, Yatabe, Yasushi, ...
Purpose: Mutation of epidermal growth factor receptor (EGFR) gene has been reported to be present in non–small cell lung cancer (NSCLC) and significantly associated with female sex and...
Gene Expression Signature Predicts Recurrence in Lung Adenocarcinoma (2007)
Larsen, Jill E., Pavey, Sandra J., Passmore, Linda H., Bowman, Rayleen V., Hayward, Nicholas K., Fong, Kwun M.
Purpose: Improving outcomes for early-stage lung cancer is a major research focus at present because a significant proportion of stage I patients develop recurrent disease within 5 years of...
Refining Prognosis in Non–Small-Cell Lung Cancer (2007)
Larsen, Jill E., Fong, Kwun M., Hayward, Nicholas K.
To the Editor: Potti et al. (Aug. 10 issue)1 apply a metagene model to the profiling of non–small-cell lung cancer (NSCLC) and demonstrate superior performance in predicting tumor recurrence and...
David S. Shames, Luc Girard, Boning Gao, Mitsuo Sato, Cheryl M. Lewis, Narayan Shivapurkar, ...
BackgroundPromoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated...
Epigenetics of lung cancer (2006)
Bowman, Rayleen V., Yang, Ian A., Semmler, Annalese B. T., Fong, Kwun M.
Epigenetics is the study of heritable changes in gene expression that occur without changes in DNA sequence. It has a role in determining when and where a gene is expressed during development....
Epigenetics of lung cancer (2006)
Bowman, Rayleen V., Yang, Ian A., Semmler, Annalese B. T., Fong, Kwun M.
Epigenetics is the study of heritable changes in gene expression that occur without changes in DNA sequence. It has a role in determining when and where a gene is expressed during development....
Shames, David S., Girard, Luc, Gao, Boning, Sato, Mitsuo, Lewis, Cheryl M., Shivapurkar, Narayan, ...
Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated during the...
Zöchbauer-Müller, Sabine, Fong, Kwun M., Geradts, Joseph, Xu, Xie, Seidl, Sonja, End-Pfützenreuter, Adelheid, ...
Recently, the human SRBC (hSRBC) gene, a candidate tumor suppressor gene (TSG), has been mapped to the chromosomal region 11p15.5–p15.4 where frequent allele loss has been described in lung cancer....
Shigematsu, Hisayuki, Lin, Li, Takahashi, Takao, Nomura, Masaharu, Suzuki, Makoto, Wistuba, Ignacio I., ...
Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that...
Shigematsu, Hisayuki, Lin, Li, Takahashi, Takao, Nomura, Masaharu, Suzuki, Makoto, Wistuba, Ignacio I., ...
Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased sensitivity of these cancers to drugs that...
Sarsero, Doreen, Russell, Fraser D., Lynham, James A., Rabnott, Glenn, Yang, Ian, Fong, Kwun M., ...
Two forms of the activated beta(1)-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists...
Sarsero, Doreen, Russell, Fraser D., Lynham, James A., Rabnott, Glenn, Yang, Ian, Fong, Kwun M., ...
Two forms of the activated beta(1)-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists...
Molecular Genetics of Lung Cancer (2003)
Sekido, Yoshitaka, Fong, Kwun M., Minna, John D.
Lung cancer results from multiple changes in the genome of susceptible pulmonary cells caused by exposure to carcinogens found in tobacco smoke, the environment, or the workplace. Recent studies...
Toyooka, Shinichi, Maruyama, Riichiroh, Toyooka, Kiyomi O., McLerran, Dale, Feng, Ziding, Fukuyama, Yasuro, ...
Aberrant methylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of lung cancers. There are major smoke exposure, histology, geography and...
Promoter Methylation and Silencing of the Retinoic Acid Receptor-ß Gene in Lung Carcinomas (2000)
Virmani, Arvind K., Rathi, Asha, Zöchbauer-Müller, Sabine, Sacchi, Nicoletta, Fukuyama, Yasuro, Bryant, David, ...
Background: Retinoic acid plays an important role in lung development and differentiation, acting primarily via nuclear receptors encoded by the retinoic acid receptor-&bgr; (RAR&bgr;) gene. Because...
Shames, David S, Girard, Luc, Gao, Boning, Sato, Mitsuo, Lewis, Cheryl M, Shivapurkar, Narayan, ...
John Minna and colleagues report that a group of genes are commonly methylated in primary lung, breast, colon, and prostate cancer.
Geradts, Joseph, Maynard, Robert, Birrer, Michael J., Hendricks, Denver, Abbondanzo, Susan L., Fong, Kwun M., ...
The metastasis suppressor gene KAI1 was identified by its ability to inhibit the formation of pulmonary metastases in experimental models for prostatic carcinoma. Down-regulation of this gene may be...
Expression profiling identifies genes involved in emphysema severity
Francis, Santiyagu M Savarimuthu, Larsen, Jill E, Pavey, Sandra J, Bowman, Rayleen V, Hayward, Nicholas K, Fong, Kwun M, ...
Chronic obstructive pulmonary disease (COPD) is a major public health problem. The aim of this study was to identify genes involved in emphysema severity in COPD patients.