Fayu Chen, Pei-san Ng, Kym F. Faull, Rehwa H. Lee
PURPOSE. To characterize the structure of cone ��-transducin (T�3�8) and its interaction with phosducin (pdc). METHODS. The T�8 subunit of T�3�8 was isolated by column chromatography...
Rhizobium common nod genes are required for biofilm formation (2008)
Fujishige, Nancy A, Lum, Michelle R, De Hoff, Peter L, Whitelegge, Julian P, Faull, Kym F, Hirsch, Ann M
In legume nitrogen-fixing symbioses, rhizobial nod genes are obligatory for initiating infection thread formation and root nodule development. Here we show that the common nod genes, nodD1ABC, whose...
Proteomics and Mass Spectrometry for Cancer Biomarker Discovery (2007)
Ming Lu, Kym F. Faull, Julian P. Whitelegge, Jianbo He, Dejun Shen, Romaine E. Saxton, ...
Proteomics is a rapidly advancing field not only in the field of biology but also in translational cancer research. In recent years, mass spectrometry and associated technologies have been explored...
Proteomic profiling of cancer biomarkers (2003)
Shau, Hungyi, Chandler, G. Scott, Whitelegge, Julian P., Gornbein, Jeffrey A., Faull, Kym F., Chang, Helena R.
Early detection and correct diagnosis are essential for effective treatment of cancer and patient survival. Complete sequencing of the human genome, and the genomes of other species, provides...
Ton-That, Hung, Mazmanian, Sarkis K., Faull, Kym F., Schneewind, Olaf
Staphylococcus aureus sortase anchors surface proteins to the cell wall envelope by cleaving polypeptides at the LPXTG motif. Surface proteins are linked to the peptidoglycan by an amide bond between...
Ton-That, Hung, Liu, Gwen, Mazmanian, Sarkis K., Faull, Kym F., Schneewind, Olaf
Surface proteins of Staphylococcus aureus are linked to the bacterial cell wall by sortase, an enzyme that cleaves polypeptides at the threonine of the LPXTG motif. Surface proteins can be released...
CSF Amine Metabolites and Depression (1987)
Peabody, Cecilia A., Faull, Kym F., King, Roy J., Whiteford, Harvey A., Barchas, Jack D., Berger, Philip A., ...
Cerebrospinal fluid (CSF) amine metabolites were measured in 37 male subjects with major depressive disorder. Scores on the Hamilton Rating Scale for Depression (HRSD) correlated significantly with...
TRH stimulation test and depression (1987)
Peabody, Cecilia A., Whiteford, Harvey A., Warner, M.Dhyanne, Faull, Kym F., Barchas, Jack D., Berger, Philip A.
A thyrotropin-releasing hormone (TRH) stimulation test was performed in 52 male inpatients with major depressive disorder. Twenty-nine percent of the 52 subjects had a delta thyroid-stimulating...
Ton-That, Hung, Liu, Gwen, Mazmanian, Sarkis K., Faull, Kym F., Schneewind, Olaf
Surface proteins of Staphylococcus aureus are linked to the bacterial cell wall by sortase, an enzyme that cleaves polypeptides at the threonine of the LPXTG motif. Surface proteins can be released...
Hydroxamate Siderophores of Histoplasma capsulatum
Howard, Dexter H., Rafie, Ramin, Tiwari, Anupama, Faull, Kym F.
The zoopathogenic fungus Histoplasma capsulatum, like other eukaryotic aerobic microorganisms, requires iron for growth. Under conditions of low iron availability, the fungus secretes hydroxamates...
Crystal structure of saposin B reveals a dimeric shell for lipid binding
Ahn, Victoria E., Faull, Kym F., Whitelegge, Julian P., Fluharty, Arvan L., Privé, Gilbert G.
Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids from...
Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry
Weinglass, Adam B., Whitelegge, Julian P., Hu, Yonglin, Verner, Gillian E., Faull, Kym F., Kaback, H.Ronald
Integration of biochemical and biophysical data on the lactose permease of Escherichia coli has culminated in a molecular model that predicts substrate–protein proximities which include interaction...
Woo, Ho-Hyung, Faull, Kym F., Hirsch, Ann M., Hawes, Martha C.
Alfalfa (Medicago sativa) and Arabidopsis were used as model systems to examine molecular mechanisms underlying developmental effects of a microsomal UDP-glucuronosyltransferase-encoding gene from...
Rodriguez, Jorge A., Shaw, Bryan Francis, Durazo, Armando, Sohn, Se Hui, Doucette, Peter A., Nersissian, Aram M., ...
The relative stabilities and structural properties of a representative set of 20 ALS-mutant Cu,Zn-superoxide dismutase apoproteins were examined by using differential scanning calorimetry and...
Ton-That, Hung, Liu, Gwen, Mazmanian, Sarkis K., Faull, Kym F., Schneewind, Olaf
Surface proteins of Staphylococcus aureus are linked to the bacterial cell wall by sortase, an enzyme that cleaves polypeptides at the threonine of the LPXTG motif. Surface proteins can be released...
Hydroxamate Siderophores of Histoplasma capsulatum
Howard, Dexter H., Rafie, Ramin, Tiwari, Anupama, Faull, Kym F.
The zoopathogenic fungus Histoplasma capsulatum, like other eukaryotic aerobic microorganisms, requires iron for growth. Under conditions of low iron availability, the fungus secretes hydroxamates...
Crystal structure of saposin B reveals a dimeric shell for lipid binding
Ahn, Victoria E., Faull, Kym F., Whitelegge, Julian P., Fluharty, Arvan L., Privé, Gilbert G.
Saposin B is a small, nonenzymatic glycosphingolipid activator protein required for the breakdown of cerebroside sulfates (sulfatides) within the lysosome. The protein can extract target lipids from...
Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry
Weinglass, Adam B., Whitelegge, Julian P., Hu, Yonglin, Verner, Gillian E., Faull, Kym F., Kaback, H.Ronald
Integration of biochemical and biophysical data on the lactose permease of Escherichia coli has culminated in a molecular model that predicts substrate–protein proximities which include interaction...
Woo, Ho-Hyung, Faull, Kym F., Hirsch, Ann M., Hawes, Martha C.
Alfalfa (Medicago sativa) and Arabidopsis were used as model systems to examine molecular mechanisms underlying developmental effects of a microsomal UDP-glucuronosyltransferase-encoding gene from...
Rodriguez, Jorge A., Shaw, Bryan Francis, Durazo, Armando, Sohn, Se Hui, Doucette, Peter A., Nersissian, Aram M., ...
The relative stabilities and structural properties of a representative set of 20 ALS-mutant Cu,Zn-superoxide dismutase apoproteins were examined by using differential scanning calorimetry and...
Identities of Sequestered Proteins in Aggregates from Cells with Induced Polyglutamine Expression
Suhr, Steven T., Senut, Marie-Claude, Whitelegge, Julian P., Faull, Kym F., Cuizon, Denise B., Gage, Fred H.
Proteins with expanded polyglutamine (polyQ) tracts have been linked to neurodegenerative diseases. One common characteristic of expanded-polyQ expression is the formation of intracellular aggregates...
Amide bonds assemble pili on the surface of bacilli
Budzik, Jonathan M., Marraffini, Luciano A., Souda, Puneet, Whitelegge, Julian P., Faull, Kym F., Schneewind, Olaf
Pilin precursors are the building blocks of pili on the surface of Gram-positive bacteria; however, the assembly mechanisms of these adhesive fibers are unknown. Here, we describe the chemical bonds...
Lanigan-Gerdes, Sara, Briceno, Geraldine, Dooley, Alek N., Faull, Kym F., Lazazzera, Beth A.
Extracellular Phr pentapeptides produced by gram-positive, spore-forming bacteria regulate processes during the transition from exponential- to stationary-phase growth. Phr pentapeptides are produced...
Anupriwan, Araya, Schenk, Matthias, Kongmanas, Kessiri, Vanichviriyakit, Rapeepun, Costa Santos, Daniela, Yaghoubian, Arman, ...
Arylsulfatase A (AS-A) is a lysosomal enzyme, which catalyzes the desulfation of certain sulfogalactolipids, including sulfogalactosylglycerolipid (SGG), a molecule implicated in cell adhesion. In...
Proteomics and Mass Spectrometry for Cancer Biomarker Discovery
Lu, Ming, Faull, Kym F., Whitelegge, Julian P., He, Jianbo, Shen, Dejun, Saxton, Romaine E., ...
Proteomics is a rapidly advancing field not only in the field of biology but also in translational cancer research. In recent years, mass spectrometry and associated technologies have been explored...