Motegi, Akira, Liaw, Hung-Jiun, Lee, Kyoo-Young, Roest, Henk P., Maas, Alex, Wu, Xiaoli, ...
Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass pathways such as postreplication repair (PRR) to resolve these...
Myung, Kyungjae, Smith, Stephanie
Genome instability is characteristic of cancer cells. Although it frequently occurs during carcinogenesis, the mechanism underlying genome instability is not clearly understood. Recent extensive...
Budd, Martin E., Reis, Clara C., Smith, Stephanie, Myung, Kyungjae, Campbell, Judith L.
The precise machineries required for two aspects of eukaryotic DNA replication, Okazaki fragment processing (OFP) and telomere maintenance, are poorly understood. In this work, we present evidence...
Motegi, Akira, Sood, Raman, Moinova, Helen, Markowitz, Sanford D., Liu, Pu Paul, Myung, Kyungjae
Differential modifications of proliferating cell nuclear antigen (PCNA) determine DNA repair pathways at stalled replication forks. In yeast, PCNA monoubiquitination by the ubiquitin ligase (E3)...
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KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion
Myung, Kyungjae, Braastad, Corey, He, Dong Ming, Hendrickson, Eric A.
The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of...
Myung, Kyungjae, Kolodner, Richard D.
Cancer cells show increased genome rearrangements, although it is unclear what defects cause these rearrangements. Previous studies have implicated the Saccharomyces cerevisiae replication checkpoint...
Myung, Kyungjae, Pennaneach, Vincent, Kats, Ellen S., Kolodner, Richard D.
Some spontaneous gross chromosomal rearrangements (GCRs) seem to result from DNA-replication errors. The chromatin-assembly factor I (CAF-I) and replication-coupling assembly factor (RCAF) complexes...
Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86
Myung, Kyungjae, Ghosh, Goutam, Fattah, Farjana J., Li, Gang, Kim, Haeyoung, Dutia, Amalia, ...
Ku86 plays a key role in nonhomologous end joining in organisms as evolutionarily disparate as bacteria and humans. In eukaryotic cells, Ku86 has also been implicated in the regulation of telomere...
Myung, Kyungjae, Smith, Stephanie, Kolodner, Richard D.
The accumulation of gross chromosomal rearrangements (GCRs) is characteristic of cancer cells. Multiple pathways that prevent GCRs, including S-phase cell cycle checkpoints, homologous recombination,...
Banerjee, Soma, Myung, Kyungjae
Gross chromosomal rearrangements (GCRs) are frequently observed in cancer cells. Abnormalities in different DNA metabolism including DNA replication, cell cycle checkpoints, chromatin remodeling,...
Motegi, Akira, Kuntz, Karen, Majeed, Anju, Smith, Stephanie, Myung, Kyungjae
Gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. Previously, we showed that inactivation of Rad5 or Rad18, ubiquitin ligases (E3) targeting for proliferating cell...
Budd, Martin E., Reis, Clara C., Smith, Stephanie, Myung, Kyungjae, Campbell, Judith L.
The precise machineries required for two aspects of eukaryotic DNA replication, Okazaki fragment processing (OFP) and telomere maintenance, are poorly understood. In this work, we present evidence...
Banerjee, Soma, Smith, Stephanie, Myung, Kyungjae
The inactivation of either subunit of the Ku70-Ku80 heterodimer, which functions in nonhomologous end-joining and telomere maintenance, generates severe defects such as sensitivity to DNA damage,...
Hwang, Ji-Young, Smith, Stephanie, Myung, Kyungjae
Gross chromosomal rearrangements (GCRs) have been observed in many cancers. Previously, we have demonstrated many mechanisms for suppression of GCR formation in yeast. However, pathways that promote...
KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion
Myung, Kyungjae, Braastad, Corey, He, Dong Ming, Hendrickson, Eric A.
The KARP-1 (Ku86 Autoantigen Related Protein-1) gene, which is expressed from the human Ku86 autoantigen locus, appears to play a role in mammalian DNA double-strand break repair as a regulator of...
Myung, Kyungjae, Kolodner, Richard D.
Cancer cells show increased genome rearrangements, although it is unclear what defects cause these rearrangements. Previous studies have implicated the Saccharomyces cerevisiae replication checkpoint...
Myung, Kyungjae, Pennaneach, Vincent, Kats, Ellen S., Kolodner, Richard D.
Some spontaneous gross chromosomal rearrangements (GCRs) seem to result from DNA-replication errors. The chromatin-assembly factor I (CAF-I) and replication-coupling assembly factor (RCAF) complexes...
Regulation of Telomere Length and Suppression of Genomic Instability in Human Somatic Cells by Ku86
Myung, Kyungjae, Ghosh, Goutam, Fattah, Farjana J., Li, Gang, Kim, Haeyoung, Dutia, Amalia, ...
Ku86 plays a key role in nonhomologous end joining in organisms as evolutionarily disparate as bacteria and humans. In eukaryotic cells, Ku86 has also been implicated in the regulation of telomere...
Myung, Kyungjae, Smith, Stephanie, Kolodner, Richard D.
The accumulation of gross chromosomal rearrangements (GCRs) is characteristic of cancer cells. Multiple pathways that prevent GCRs, including S-phase cell cycle checkpoints, homologous recombination,...
Banerjee, Soma, Myung, Kyungjae
Gross chromosomal rearrangements (GCRs) are frequently observed in cancer cells. Abnormalities in different DNA metabolism including DNA replication, cell cycle checkpoints, chromatin remodeling,...
Motegi, Akira, Kuntz, Karen, Majeed, Anju, Smith, Stephanie, Myung, Kyungjae
Gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. Previously, we showed that inactivation of Rad5 or Rad18, ubiquitin ligases (E3) targeting for proliferating cell...
Banerjee, Soma, Smith, Stephanie, Myung, Kyungjae
The inactivation of either subunit of the Ku70-Ku80 heterodimer, which functions in nonhomologous end-joining and telomere maintenance, generates severe defects such as sensitivity to DNA damage,...
Budd, Martin E., Reis, Clara C., Smith, Stephanie, Myung, Kyungjae, Campbell, Judith L.
The precise machineries required for two aspects of eukaryotic DNA replication, Okazaki fragment processing (OFP) and telomere maintenance, are poorly understood. In this work, we present evidence...
Hwang, Ji-Young, Smith, Stephanie, Myung, Kyungjae
Gross chromosomal rearrangements (GCRs) have been observed in many cancers. Previously, we have demonstrated many mechanisms for suppression of GCR formation in yeast. However, pathways that promote...
Motegi, Akira, Sood, Raman, Moinova, Helen, Markowitz, Sanford D., Liu, Pu Paul, Myung, Kyungjae
Differential modifications of proliferating cell nuclear antigen (PCNA) determine DNA repair pathways at stalled replication forks. In yeast, PCNA monoubiquitination by the ubiquitin ligase (E3)...
Dynamic Regulation of Single-Stranded Telomeres in Saccharomyces cerevisiae
Smith, Stephanie, Banerjee, Soma, Rilo, Regina, Myung, Kyungjae
The temperature-sensitive phenotypes of yku70Δ and yku80Δ have provided a useful tool for understanding telomere homeostasis. Mutating the helicase domain of the telomerase inhibitor Pif1 resulted...
Spt2p Defines a New Transcription-Dependent Gross Chromosomal Rearrangement Pathway
Sikdar, Nilabja, Banerjee, Soma, Zhang, Han, Smith, Stephanie, Myung, Kyungjae
Large numbers of gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. High mobility group 1 (HMG1) protein is a non-histone DNA-binding protein and is highly expressed in...
Banerjee, Soma, Smith, Stephanie, Oum, Ji-Hyun, Liaw, Hung-Jiun, Hwang, Ji-Young, Sikdar, Nilabja, ...
Gross chromosomal rearrangement (GCR) is a type of genomic instability associated with many cancers. In yeast, multiple pathways cooperate to suppress GCR. In a screen for genes that promote GCR, we...
Motegi, Akira, Liaw, Hung-Jiun, Lee, Kyoo-Young, Roest, Henk P., Maas, Alex, Wu, Xiaoli, ...
Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass pathways such as postreplication repair (PRR) to resolve these...