Microbial hyaluronic acid production (2005)
Chong, B. F., Blank, L., McLaughlin, R. L., Nielsen, L. K.
Hyaluronic acid (HA) is a commercially valuable medical biopolymer increasingly produced through microbial fermentation. Viscosity limits product yield and the focus of research and development has...
Multiscale Concepts for Moving Horizon Optimization (2001)
T. Binder, L. Blank, W. Dahmen, W. Marquardt, M. Grotschel, S. O. Krumke, ...
In chemical engineering complex dynamic optimization problems formulated on moving horizons have to be solved on-line. In this work, we present a multiscale approach based on wavelets where a...
Iterative Algorithms for Multiscale State Estimation, Part 2: Numerical Investigation (2001)
T. Binder, L. Blank, W. Dahmen, W. Marquardt
Usually direct methods are employed for the solution of linear systems arising in the context of optimization. However, motivated by the potential of multiscale refinement schemes for large problems...
On The Regularization Of Dynamic Data Reconciliation Problems (2001)
T. Binder, L. Blank, W. Dahmen, W. Marquardt
Dynamic data reconciliation problems are discussed from the perspective of the mathematical theory of ill-posed inverse problems. Regularization is of crucial importance to obtain satisfactory...
Iterative Algorithms for Multiscale State Estimation, Part 1: Concept (2001)
T. Binder, L. Blank, W. Dahmen, W. Marquardt
The objective of the present investigation is to explore the potential of multiscale re nement schemes for the numerical solution of dynamic optimization problems arising in connection with chemical...
Iterative Multiscale Methods for Process Monitoring (2000)
Der Deutschen, Forschungsgemeinschaft Schwerpunktprogramm, T. Binder, L. Blank, W. Dahmen, W. Marquardt
Process monitoring via state estimation is accomplished by the solution of an appropriately posed optimization problem on a receding horizon. The need of a fast solution of the optimization problem...
Grosser Systeme Echtzeitoptimierung (2000)
Schwerpunktprogramm Der, Deutschen Forschungsgemeinschaft Binder, T. Binder, L. Blank, W. Dahmen, W. Marquardt
In the present work we explore an adaptive discretization scheme for dynamic optimization problems formulated on moving horizons. The proposed method is embedded into a solution methodology where the...
Iterative Algorithms for Multiscale Dynamic Data Reconciliation (2000)
Der Deutschen, Forschungsgemeinschaft Schwerpunktprogramm, T. Binder, L. Blank, W. Dahmen, W. Marquardt
The objective of the present investigation is to explore the potential of multiscale renement schemes for the numerical solution of large constrained dynamic optimization problems arising in...
Grid Refinement in Multiscale Dynamic Optimization (2000)
Schwerpunktprogramm Der, Deutschen Forschungsgemeinschaft Binder, T. Binder, L. Blank, W. Dahmen, W. Marquardt
In the present work we explore an adaptive discretization scheme for dynamic optimization problems applied to input and state estimation. The proposed method is embedded into a solution methodology...
Towards Multiscale Dynamic Data Reconciliation (2000)
Schwerpunktprogramm Der, Deutschen Forschungsgemeinschaft Binder, T. Binder, L. Blank, W. Dahmen, W. Marquardt
Although reconciliation of steady-state process data is routinely applied in industrial practice, the theoretical understanding of the problem and its adequate formulation in a dynamic setting is...
Regularization of Dynamic Data Reconciliation Problems (2000)
Schwerpunktprogramm Der, Deutschen Forschungsgemeinschaft Binder, T. Binder, L. Blank, W. Dahmen, W. Marquardt
Dynamic data reconciliation problems are discussed from the perspective of the mathematical theory of ill-posed inverse problems. Regularization is of crucial importance to obtain satisfactory...
An Adaptive Multiscale Method for Real-Time Moving Horizon Optimization (2000)
Rwth Aachen, T. Binder, L. Blank, W. Dahmen, W. Marquardt
In the present work we explore an adaptive discretization scheme for dynamic optimization problems formulated on moving horizons. The proposed method is embedded into a solution methodology where the...
Grid Refinement in Multiscale Dynamic Optimization (2000)
Rwth Aachen, T. Binder, L. Blank, W. Dahmen, W. Marquardt
In the present work we explore an adaptive discretization scheme for dynamic optimization problems applied to input and state estimation. The proposed method is embedded into a solution methodology...
Iterative Algorithms for Multiscale Dynamic Data Reconciliation (2000)
T. Binder, L. Blank, W. Dahmen, W. Marquardt
The objective of the present investigation is to explore the potential of multiscale renement schemes for the numerical solution of large constrained dynamic optimization problems arising in...
ESTRO/EAU/EORTC recommendations on permanent seed implantation for localized prostate cancer (2000)
Ash, D., Flynn, A., Battermann, J.J., Reijke, Th.M. De, Lavagnini, P., Blank, L.
Regularization Of Dynamic Data Reconciliation Problems By Projection (1999)
T. Binder, L. Blank, W. Dahmen, W. Marquardt
Dynamic data reconciliation problems are discussed from the perspective of the mathematical theory of ill--posed inverse problems. Regularization is of crucial importance to obtain satisfactory...
Reducing inequalities in access to health care: developing a toolkit through action research
Goyder, E, Blank, L, Ellis, E, Furber, A, Peters, J, Sartain, K, ...
Problem: Healthcare organisations are expected both to monitor inequalities in access to health services and also to act to improve access and increase equity in service provision.