Smith, L, Qutob, O, Watson, MB, Beavis, AW, Lind, MJ, Drew, PJ, ...
No abstract available.
Smith, L, Qutob, O, Watson, MB, Beavis, AW, Jameel, JKA, Welham, KJ, ...
No abstract available.
Smith, L, Potts, D, Qutob, O, Watson, MB, Beavis, AW, Lind, MJ, ...
No abstract available.
Association between family history and mismatch repair in colorectal cancer (2005)
Coggins, R.P., Cawkwell, L., Bell, S.M., Crockford, G.P., Quirke, P., Finan, P.J., ...
BACKGROUND AND AIMS: Germline mutations in mismatch repair (MMR) genes cause a greatly increased risk of cancer of the gastrointestinal and female reproductive tracts (hereditary non-polyposis...
Association between family history and mismatch repair in colorectal cancer (2005)
Coggins, R.P., Cawkwell, L., Bell, S.M., Crockford, G.P., Quirke, P., Finan, P.J., ...
BACKGROUND AND AIMS: Germline mutations in mismatch repair (MMR) genes cause a greatly increased risk of cancer of the gastrointestinal and female reproductive tracts (hereditary non-polyposis...
Association between family history and mismatch repair in colorectal cancer (2005)
Coggins, R.P., Cawkwell, L., Bell, S.M., Crockford, G.P., Quirke, P., Finan, P.J., ...
BACKGROUND AND AIMS: Germline mutations in mismatch repair (MMR) genes cause a greatly increased risk of cancer of the gastrointestinal and female reproductive tracts (hereditary non-polyposis...
Turnbull, LW, Manton, DJ, Lowry, M, Maraveyas, A, Chaturvedi, A, Greenman, J, ...
No abstract available.
Rafferty, J A, Elder, R H, Watson, A J, Cawkwell, L, Potter, P M, Margison, G P
The cDNA encoding Chinese hamster O6-alkylguanine-DNA-alkyltransferase (ATase) has been isolated from a library prepared from RNA isolated from V79 lung fibroblasts which had an upregulated level of...
Expression of a human O6-alkylguanine-DNA-alkyltransferase cDNA in human cells and transgenic mice.
Fan, C Y, Potter, P M, Rafferty, J, Watson, A J, Cawkwell, L, Searle, P F, ...
A truncated human O6-alkylguanine-DNA-alkyltransferase (ATase) cDNA was ligated into an expression vector under the control of the mouse metallothionein-1 gene promotor and upstream of part of the...
Expression of the ogt gene in wild-type and ada mutants of E. coli.
Potter, P M, Kleibl, K, Cawkwell, L, Margison, G P
O6-alkylguanine (O6-AlkG) DNA alkyltransferase (ATase) and alkylphosphotriester (AlkP) ATase activity have been quantitated individually in extracts of various E. coli strains by means of ATase...
Wilkinson, M C, Potter, P M, Cawkwell, L, Georgiadis, P, Patel, D, Swann, P F, ...
The E. coli gene ogt encodes the DNA repair protein O6-alkylguanine-DNA-alkyltransferase (O6-AlkG ATase). The protein coding region of the gene was cloned into a multicopy expression vector to obtain...
Direct multiplex amplification of DNA from a formalin fixed, paraffin wax embedded tissue section
The extraction of DNA from formalin fixed, paraffin wax embedded tissue can be problematical, with long protocols producing low yields. This report describes a very simple and useful method for...
Rafferty, J A, Elder, R H, Watson, A J, Cawkwell, L, Potter, P M, Margison, G P
The cDNA encoding Chinese hamster O6-alkylguanine-DNA-alkyltransferase (ATase) has been isolated from a library prepared from RNA isolated from V79 lung fibroblasts which had an upregulated level of...
Expression of a human O6-alkylguanine-DNA-alkyltransferase cDNA in human cells and transgenic mice.
Fan, C Y, Potter, P M, Rafferty, J, Watson, A J, Cawkwell, L, Searle, P F, ...
A truncated human O6-alkylguanine-DNA-alkyltransferase (ATase) cDNA was ligated into an expression vector under the control of the mouse metallothionein-1 gene promotor and upstream of part of the...
Expression of the ogt gene in wild-type and ada mutants of E. coli.
Potter, P M, Kleibl, K, Cawkwell, L, Margison, G P
O6-alkylguanine (O6-AlkG) DNA alkyltransferase (ATase) and alkylphosphotriester (AlkP) ATase activity have been quantitated individually in extracts of various E. coli strains by means of ATase...
Wilkinson, M C, Potter, P M, Cawkwell, L, Georgiadis, P, Patel, D, Swann, P F, ...
The E. coli gene ogt encodes the DNA repair protein O6-alkylguanine-DNA-alkyltransferase (O6-AlkG ATase). The protein coding region of the gene was cloned into a multicopy expression vector to obtain...
Direct multiplex amplification of DNA from a formalin fixed, paraffin wax embedded tissue section
The extraction of DNA from formalin fixed, paraffin wax embedded tissue can be problematical, with long protocols producing low yields. This report describes a very simple and useful method for...
Frequency of replication errors in colorectal cancer and their association with family history
Brown, S, Finan, P, Cawkwell, L, Quirke, P, Bishop, D
a Centre for Digestive Diseases, Leeds General Infirmary, b Department of Molecular Oncology, University of Leeds, c Imperial Cancer Research Fund, Genetic Epidemiology Department, St James's...
Cawkwell, L, Gray, S, Murgatroyd, H, Sutherland, F, Haine, L, Longfellow, M, ...
BACKGROUND—Despite intensive research into the molecular abnormalities associated with colorectal cancer (CRC), no diagnostic tests have emerged which usefully complement standard histopathological...
Cawkwell, L, Sutherland, F, Murgatroyd, H, Jarvis, P, Gray, S, Cross, D, ...
BACKGROUND—Ulcerative colitis is associated with an increased risk of colorectal cancer above that of the normal population. The relative risk correlates with the extent and duration of the disease...
Association between family history and mismatch repair in colorectal cancer
Coggins, R P, Cawkwell, L, Bell, S M, Crockford, G P, Quirke, P, Finan, P J, ...
Background and aims: Germline mutations in mismatch repair (MMR) genes cause a greatly increased risk of cancer of the gastrointestinal and female reproductive tracts (hereditary non-polyposis...