L. Clarke

Publication List Details

Period

1960 - 2009

Number

75

Co-Authors

Endothelial injury and repair in vasculitis of the young (2009)

Clarke, L.

The vasculitides are a wide spectrum of disorders which are characterised by vascular inflammation. Endothelial injury can occur as a consequence of inappropriate inflammation and is central to the...

Ensembl 2009 (2009)

Hubbard, T. J. P., Aken, B. L., Ayling, S., Ballester, B., Beal, K., Bragin, E., ...

The Ensembl project (http://www.ensembl.org) is a comprehensive genome information system featuring an integrated set of genome annotation, databases, and other information for chordate, selected...

Interlaboratory comparison study of calibration standards for foraminiferal Mg/Ca thermometry (2008)

Greaves, M., Caillon, N., Rebaubier, H., Bartoli, G., Bohaty, S., Cacho, I., ...

An interlaboratory study of Mg/Ca and Sr/Ca ratios in three commercially available carbonate reference materials (BAM RS3, CMSI 1767, and ECRM 752-1) was performed with the participation of 25...

Engaging students and new teachers with values: How can teacher education in Northern Ireland be improved? (2008)

Smith, A, Moran, A, Clarke, L, McCully, A

Teacher education in Northern Ireland is undergoing a substantial review and this research was carried out during a period when teach education was being closely scrutinised. The General Teaching...

A values-based approach to teacher education - TLRP Research Briefing 35 (2008)

Smith, A, Moran, A, Clarke, L, McCully, A, Abbott, L, Montgomery, A

This research explored students’ and beginning teachers’ experiences of teacher education and professional development in Northern Ireland. It focused on their perceptions and understanding of...

'Put posters over the glass bit in the door and disappear': tutor perspectives on the use of VLEs to support pre-service teachers (2008)

Clarke, L, Abbott, L

This study examines the perspectives of teacher tutors on the value of the online components of PGCE (Post Graduate Certificate of Education) courses at the University of Ulster. The work has been...

Ensembl 2008 (2008)

Flicek, P., Aken, B. L., Beal, K., Ballester, B., Caccamo, M., Chen, Y., ...

The Ensembl project (http://www.ensembl.org) is a comprehensive genome information system featuring an integrated set of genome annotation, databases and other information for chordate and selected...

Supporting beginning teachers using VLEs (2007)

Clarke, L

This paper is timely; both its origins and prospects are based in a concurrence of policy and infrastructural affordances, which may offer a singularly promising combination of vision and pragmatics....

Ensembl 2007 (2007)

Hubbard, T. J. P., Aken, B. L., Beal, K., Ballester, B., Caccamo, M., Chen, Y., ...

The Ensembl (http://www.ensembl.org/) project provides a comprehensive and integrated source of annotation of chordate genome sequences. Over the past year the number of genomes available from...

Ensembl 2007 (2006)

Hubbard, T. J. P., Aken, B. L., Beal, K., Ballester, B., Caccamo, M., Chen, Y., ...

The Ensembl (http://www.ensembl.org/) project provides a comprehensive and integrated source of annotation of chordate genome sequences. Over the past year the number of genomes available from...

Ensembl 2007 (2006)

Hubbard, T. J. P., Aken, B. L., Beal, K., Ballester, B., Caccamo, M., Chen, Y., ...

The Ensembl (http://www.ensembl.org/) project provides a comprehensive and integrated source of annotation of chordate genome sequences. Over the past year the number of genomes available from...

Ensembl 2006 (2006)

Birney, E., Andrews, D., Caccamo, M., Chen, Y., Clarke, L., Coates, G., ...

The Ensembl (http://www.ensembl.org/) project provides a comprehensive and integrated source of annotation of large genome sequences. Over the last year the number of genomes available from the...

Ensembl 2007 (2006)

Hubbard, T. J. P., Aken, B. L., Beal, K., Ballester, B., Caccamo, M., Chen, Y., ...

The Ensembl (http://www.ensembl.org/) project provides a comprehensive and integrated source of annotation of chordate genome sequences. Over the past year the number of genomes available from...

Ensembl 2007 (2006)

Hubbard, T. J. P., Aken, B. L., Beal, K., Ballester, B., Caccamo, M., Chen, Y., ...

The Ensembl (http://www.ensembl.org/) project provides a comprehensive and integrated source of annotation of chordate genome sequences. Over the past year the number of genomes available from...

A Values-Based Approach to Teacher Education - poster (2005)

Smith, A, Moran, A, McCully, A, Clarke, L

This poster describes the rationale and methods of the project A Values-Based Approach to Teacher Education. Within the context of a government review of the future of teacher education, the aims of...

Ensembl 2005 (2005)

Hubbard, T., Andrews, D., Caccamo, M., Cameron, G., Chen, Y., Clamp, M., ...

The Ensembl (http://www.ensembl.org/) project provides a comprehensive and integrated source of annotation of large genome sequences. Over the last year the number of genomes available from the...

Ensembl 2004 (2004)

Birney, E., Andrews, D., Bevan, P., Caccamo, M., Cameron, G., Chen, Y., ...

The Ensembl (http://www.ensembl.org/) database project provides a bioinformatics framework to organize biology around the sequences of large genomes. It is a comprehensive and integrated source of...

CIGR E-Journal Volume 4 (2002)

Ajav, E.A., Akingbehin, O.A., Alchanatis, V., Auernhammer, H., Behrens, F., Bishop, C., ...

Rosana G. Moreira, Editor-in-Chief; Texas A&M University

Moral Panic A reassessment of the gender issue in relation to childrens writing (2001)

L Clarke

Concern throughout the 1980s and part of the 1990s about the underachievement of girls has very dramatically changed its focus in the last 10 years to the underachievement of boys. Data now shows...

The Shi'i Construction of Taqlid (2001)

Clarke, L.

The essay outlines some of the controversies associated with the construction of taqlid argued by Twelver Shi'i scholars in both classical and modern juridical treatises, with illustrations of the...

Diverse family living situations and child development: a multi-level analysis comparing longitudinal evidence from Britain and The United States (1999)

Joshi, H, Cooksey, EC, Wiggins, RD, McCulloch, A, Verropoulou, G, Clarke, L

This study uses national data from both Great Britain and the United States to examine the relationship between children's family history and their educational and behavioural development. We use a...

ALF: A Framework for Building Process-Centered Software Engineering (1994)

Gérome Canals, P. A. Ng, C. V. Ramamoorthy, L. C. Seifert, R. T. Yeh, Proceedings Of The, ...

Specification. Standard ecma-149, European Computer Manufacturers Association, December 1990. [17] C. Godart. COO: a Transaction Model to support COOperating software developers COOperation. In...

Cloning and mapping of the {alpha}-adducin gene close to D4S95 and assessment of its relationship to Huntington disease (1992)

Goldberg, Y.P., Andrew, S.E., Nasir, J., Graham, R., Glaves, M.L., ...

The genetic defect underlying Huntington's disease (HD) has been mapped to 4p16.3. Refined localization using recombinant HD chromosome analysis and allelic association analyses have Identified two...

Notes on the State of Digital Computing in the U.S.S.R. (1960)

Clarke, L.

This paper, which was presented at the Harrogate Conference of The British Computer Society on 6 July 1960, gives an informal account of the state of computing in the U.S.S.R. as it appeared during a...

Clustered tRNA genes in Schizosaccharomyces pombe centromeric DNA sequence repeats.

Kuhn, R M, Clarke, L, Carbon, J

The centromere-associated B' and B DNA sequence repeats of Schizosaccharomyces pombe chromosomes I and II have been found to contain clusters of tRNA genes. The centromere II region (cen2) includes...

Replication of centromere II of Schizosaccharomyces pombe.

Smith, J G, Caddle, M S, Bulboaca, G H, Wohlgemuth, J G, Baum, M, Clarke, L, ...

The centromeric DNAs of Schizosaccharomyces pombe chromosomes resemble those of higher eukaryotes in being large and composed predominantly of repeated sequences. To begin a detailed analysis of the...

The centromere enhancer mediates centromere activation in Schizosaccharomyces pombe.

Ngan, V K, Clarke, L

The centromere enhancer is a functionally important DNA region within the Schizosaccharomyces pombe centromeric K-type repeat. We have previously shown that addition of the enhancer and cen2...

Comparison of HEp-2 cell culture and Abbott respiratory syncytial virus enzyme immunoassay.

Bromberg, K, Tannis, G, Daidone, B, Clarke, L, Sierra, M

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in children. Rapid identification of RSV infections would allow for specific chemotherapy. We evaluated a...

Comparison of immediate and delayed inoculation of HEp-2 cells for isolation of respiratory syncytial virus.

Bromberg, K, Daidone, B, Clarke, L, Sierra, M F

Immediate inoculation of HEp-2 cells is generally advocated for the isolation of respiratory syncytial virus. However, delayed laboratory inoculation of properly transported specimens obtained by...

Comparison of ortho respiratory syncytial virus enzyme-linked immunosorbent assay and HEp-2 cell culture.

Bromberg, K, Tannis, G, Daidone, B, Clarke, L, Sierra, M F

Two hundred seventy nasopharyngeal aspirates were tested in duplicate with the Ortho Diagnostics, Inc. (Raritan, N.J.), respiratory syncytial virus antigen enzyme-linked immunosorbent assay. The test...

Construction of functional artificial minichromosomes in the fission yeast Schizosaccharomyces pombe.

Hahnenberger, K M, Baum, M P, Polizzi, C M, Carbon, J, Clarke, L

The centromere DNAs from chromosomes I and III of Schizosaccharomyces pombe have been cloned in an artificial chromosome vector in both budding and fission yeasts. In S. pombe, synthetic linear and...

The centromeric K-type repeat and the central core are together sufficient to establish a functional Schizosaccharomyces pombe centromere.

Baum, M, Ngan, V K, Clarke, L

The DNA requirements for centromere function in fission yeast have been investigated using a minichromosome assay system. Critical elements of Schizosaccharomyces pombe centromeric DNA are portions...

Ensembl 2004

Birney, E., Andrews, D., Bevan, P., Caccamo, M., Cameron, G., Chen, Y., ...

The Ensembl (http://www.ensembl.org/) database project provides a bioinformatics framework to organize biology around the sequences of large genomes. It is a comprehensive and integrated source of...

Isolation of the centromere-linked CDC10 gene by complementation in yeast.

Clarke, L, Carbon, J

A hybrid plasmid colony bank was constructed in Escherichia coli using the E. coli-Saccharomyces cerevisiae shuttle vector pLC544 and randomly sheared segments of yeast DNA. By transformation with a...

Identification of DNA regions required for mitotic and meiotic functions within the centromere of Schizosaccharomyces pombe chromosome I.

Hahnenberger, K M, Carbon, J, Clarke, L

We have determined the structural organization and functional roles of centromere-specific DNA sequence repeats in cen1, the centromere region from chromosome I of the fission yeast...

Centromeres of the fission yeast Schizosaccharomyces pombe are highly variable genetic loci.

Steiner, N C, Hahnenberger, K M, Clarke, L

Gross variations in the structure of the centromere of Schizosaccharomyces pombe chromosome III (cen3) were apparent following characterization of this centromeric DNA in strain Sp223 and comparison...

Functional analysis of a centromere from fission yeast: a role for centromere-specific repeated DNA sequences.

Clarke, L, Baum, M P

A circular minichromosome carrying functional centromere sequences (cen2) from Schizosaccharomyces pombe chromosome II behaves as a stable, independent genetic linkage group in S. pombe. The cen2...

Structural organization and functional analysis of centromeric DNA in the fission yeast Schizosaccharomyces pombe.

Fishel, B, Amstutz, H, Baum, M, Carbon, J, Clarke, L

Centromeric DNA in the fission yeast Schizosaccharomyces pombe was isolated by chromosome walking and by field inversion gel electrophoretic fractionation of large genomic DNA restriction fragments....

Analysis of centromeric DNA in the fission yeast Schizosaccharomyces pombe.

Clarke, L, Amstutz, H, Fishel, B, Carbon, J

The Schizosaccharomyces pombe centromere-linked genes, LYS1 and CYH1 on chromosome I and TPS13 and RAN1 on chromosome II, have been isolated. The genetic order of these markers with respect to their...

Biochemical construction and selection of hybrid plasmids containing specific segments of the Escherichia coli genome.

Clarke, L, Carbon, J

Using a poly(dA-dT) "connector" method, a population of annealed hybrid circular DNAs was constructed in vitro; each hybrid DNA circle containing one full-length molecule of poly(dT)-tailed DNA from...

Ensembl 2005

Hubbard, T., Andrews, D., Caccamo, M., Cameron, G., Chen, Y., Clamp, M., ...

The Ensembl (http://www.ensembl.org/) project provides a comprehensive and integrated source of annotation of large genome sequences. Over the last year the number of genomes available from the...

Effect of maternal cold exposure on brown adipose tissue and thermogenesis in the neonatal lamb.

Symonds, M E, Bryant, M J, Clarke, L, Darby, C J, Lomax, M A

1. This study examines the effect of chronic cold exposure during pregnancy, induced by winter shearing twin-bearing ewes 4 weeks before predicted lambing date, on O2 consumption and CO2 production...

Implementing a community-based social marketing project to improve agricultural worker health.

Flocks, J, Clarke, L, Albrecht, S, Bryant, C, Monaghan, P, Baker, H

The Together for Agricultural Safety project is a community-based social marketing project working to reduce the adverse health effects of pesticide exposure among fernery and nursery workers in...

Ensembl 2006

Birney, E., Andrews, D., Caccamo, M., Chen, Y., Clarke, L., Coates, G., ...

The Ensembl () project provides a comprehensive and integrated source of annotation of large genome sequences. Over the last year the number of genomes available from the Ensembl site has increased...

Functional redundancies, distinct localizations and interactions among three fission yeast homologs of centromere protein-B.

Irelan, J T, Gutkin, G I, Clarke, L

Several members of protein families that are conserved in higher eukaryotes are known to play a role in centromere function in the fission yeast Schizosaccharomyces pombe, including two homologs of...

Nonsense-codon mutations of the ornithine aminotransferase gene with decreased levels of mutant mRNA in gyrate atrophy.

Mashima, Y, Murakami, A, Weleber, R G, Kennaway, N G, Clarke, L, Shiono, T, ...

A generalized deficiency of the mitochondrial matrix enzyme ornithine aminotransferase (OAT) is the inborn error in gyrate atrophy (GA), an autosomal recessive degenerative disease of the retina and...

Ensembl 2007

Hubbard, T. J. P., Aken, B. L., Beal, K., Ballester, B., Caccamo, M., Chen, Y., ...

The Ensembl () project provides a comprehensive and integrated source of annotation of chordate genome sequences. Over the past year the number of genomes available from Ensembl has increased from 15...

Adenosine receptors on human airway epithelia and their relationship to chloride secretion.

Lazarowski, E. R., Mason, S. J., Clarke, L., Harden, T. K., Boucher, R. C.

1. We have characterized an adenosine receptor subtype present in human airway epithelial cells by measuring the changes in the intracellular levels of adenosine 3':5'-cyclic monophosphate (cyclic...

Ensembl 2008

Flicek, P., Aken, B. L., Beal, K., Ballester, B., Caccamo, M., Chen, Y., ...

The Ensembl project (http://www.ensembl.org) is a comprehensive genome information system featuring an integrated set of genome annotation, databases and other information for chordate and selected...

Unintentional injury depictions in popular children's television programs

Glik, D, Kinsler, J, Todd, W, Clarke, L, Fazio, K, Miyashiro, R, ...

Objectives: The frequency and magnitude of depictions of risky events and unintentional injuries in top ranked children's animated and live action television programs was assessed.

Anxiety in patients with symptomatic breast disease: effects of immediate versus delayed communication of results.

Ubhi, S. S., Shaw, P., Wright, S., Stotter, A., Clarke, L., Windle, R., ...

Immediate reporting of fine needle aspiration biopsy (FNAB) specimens has been introduced into many breast clinics; in others, women return to a later clinic to receive the result. This delay in...

Prioritizing development goals in low-income developing countries

Ehie, Ic, Benjamin, Co, Omurtag, Y, Clarke, L

This paper outlines a systematic approach to prioritizing the multiple and often conflicting development goals and objectives in a typical low-income developing country (LDC). First, a hierarchy of...

Maternal dexamethasone administration and the maturation of perirenal adipose tissue of the neonatal sheep

Gnanalingham, MG, Hyatt, MA, Bispham, J, Mostyn, A, Clarke, L, Budge, H, ...

Maternal dexamethasone administration promotes fetal maturation such that thermoregulation is improved following premature delivery and is thus comparable with a full term birth. In the present study...

Ensembl 2009

Hubbard, T. J. P., Aken, B. L., Ayling, S., Ballester, B., Beal, K., Bragin, E., ...

The Ensembl project (http://www.ensembl.org) is a comprehensive genome information system featuring an integrated set of genome annotation, databases, and other information for chordate, selected...