Nishihara, H, Hwang, M, Kizaka-Kondoh, S, Eckmann, L, Insel, P A
We recently reported that cAMP suppresses apoptosis in colon cancer cells and induces cellular inhibitor of apoptosis protein-2 (c-IAP2) via a cAMP-responsive element (CRE), suggesting a mechanism...
Hsu, LC, Park, JM, Zhang, KZ, Luo, JL, Maeda, S, Kaufman, RJ, ...
Macrophages are pivotal constituents of the innate immune system, vital for recognition and elimination of microbial pathogens(1). Macrophages use Toll-like receptors (TLRs) to detect...
A surface amebic cysteine proteinase inactivates interleukin-18 (2003)
Que, X C, Kim, S H, Sajid, M, Eckmann, L, Dinarello, C A, McKerrow, J H, ...
Amebiasis is a major cause of morbidity and mortality worldwide. Invasion by Entamoeba histolytica trophozoites causes secretion of proinflammatory cytokines from host epithelial cells, leading to a...
Chen, C Y, Eckmann, L, Libby, S J, Fang, F C, Okamoto, S, Kagnoff, M F, ...
Adaptation to the intracellular environment of host cells is crucial for the pathogenesis of Salmonella infections. The alternative sigma factor RpoS is a global regulator of gene expression during...
Weintraub, B C, Eckmann, L, Okamoto, S, Hense, M, Hedrick, S M, Fierer, J
Salmonella spp. are facultative intracellular bacteria which enter the body through the intestinal tract. We studied the roles of T cells expressing either the alpha and beta chains or the gamma and...
Laurent, F, Eckmann, L, Savidge, T C, Morgan, G, Theodos, C, Naciri, M, ...
Cryptosporidium parvum infects intestinal epithelial cells and does not invade deeper layers of the intestinal mucosa. Nonetheless, an inflammatory cell infiltrate that consists of neutrophils and...
Cole, S P, Cirillo, D, Kagnoff, M F, Guiney, D G, Eckmann, L
Helicobacter pylori exists as an actively dividing spiral form and a nonculturable, but viable, metabolizing coccoid form. Both forms are present in the stomach, but their relative pathophysiologic...
Eckmann, L, Reed, S L, Smith, J R, Kagnoff, M F
Infection with the protozoan parasite Entamoeba histolytica results in a high mortality worldwide. To initiate infection, E. histolytica trophozoites in the bowel lumen penetrate the epithelium, and...
Eickhoff, C. S., Eckmann, L., Hoft, D. F.
Trypanosoma cruzi metacyclic trypomastigotes (MT), but not blood form trypomastigotes (BFT), are highly mucosally infective. We investigated the abilities of MT and BFT to induce inflammation and/or...
Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry.
Eckmann, L, Kagnoff, M F, Fierer, J
Bacterial invasion of mucosal surfaces results in a rapid influx of polymorphonuclear leukocytes. The chemotactic stimulus responsible for this response is not known. Since epithelial cells are among...
Fierer, J, Eckmann, L, Fang, F, Pfeifer, C, Finlay, B B, Guiney, D
Certain serotypes of salmonellae carry virulence plasmids that greatly enhance the pathogenicity of these bacteria in experimentally infected mice. This phenotype is largely attributable to the 8-kb...
Jung, H C, Eckmann, L, Yang, S K, Panja, A, Fierer, J, Morzycka-Wroblewska, E, ...
Pathogenic bacteria that penetrate the intestinal epithelial barrier stimulate an inflammatory response in the adjacent intestinal mucosa. The present studies asked whether colon epithelial cells can...
Huang, G T, Eckmann, L, Savidge, T C, Kagnoff, M F
The acute host response to gastrointestinal infection with invasive bacteria is characterized by an accumulation of neutrophils in the lamina propria, and neutrophil transmigration to the luminal...
Rasmussen, S J, Eckmann, L, Quayle, A J, Shen, L, Zhang, Y X, Anderson, D J, ...
Chlamydia species infect epithelial cells at mucosal surfaces, and are major causes of sexually transmitted diseases. Infection is characterized by inflammation which is exacerbated upon reinfection,...
Eckmann, L, Stenson, W F, Savidge, T C, Lowe, D C, Barrett, K E, Fierer, J, ...
Increased intestinal fluid secretion is a protective host response after enteric infection with invasive bacteria that is initiated within hours after infection, and is mediated by prostaglandin H...
Apoptosis of human intestinal epithelial cells after bacterial invasion.
Kim, J M, Eckmann, L, Savidge, T C, Lowe, D C, Witthöft, T, Kagnoff, M F
Epithelial cells that line the human intestinal mucosa are the initial site of host invasion by bacterial pathogens. The studies herein define apoptosis as a new category of intestinal epithelial...
Chen, C Y, Eckmann, L, Libby, S J, Fang, F C, Okamoto, S, Kagnoff, M F, ...
Adaptation to the intracellular environment of host cells is crucial for the pathogenesis of Salmonella infections. The alternative sigma factor RpoS is a global regulator of gene expression during...
Weintraub, B C, Eckmann, L, Okamoto, S, Hense, M, Hedrick, S M, Fierer, J
Salmonella spp. are facultative intracellular bacteria which enter the body through the intestinal tract. We studied the roles of T cells expressing either the alpha and beta chains or the gamma and...
Laurent, F, Eckmann, L, Savidge, T C, Morgan, G, Theodos, C, Naciri, M, ...
Cryptosporidium parvum infects intestinal epithelial cells and does not invade deeper layers of the intestinal mucosa. Nonetheless, an inflammatory cell infiltrate that consists of neutrophils and...
Cole, S P, Cirillo, D, Kagnoff, M F, Guiney, D G, Eckmann, L
Helicobacter pylori exists as an actively dividing spiral form and a nonculturable, but viable, metabolizing coccoid form. Both forms are present in the stomach, but their relative pathophysiologic...
Eckmann, L, Reed, S L, Smith, J R, Kagnoff, M F
Infection with the protozoan parasite Entamoeba histolytica results in a high mortality worldwide. To initiate infection, E. histolytica trophozoites in the bowel lumen penetrate the epithelium, and...
Eickhoff, C. S., Eckmann, L., Hoft, D. F.
Trypanosoma cruzi metacyclic trypomastigotes (MT), but not blood form trypomastigotes (BFT), are highly mucosally infective. We investigated the abilities of MT and BFT to induce inflammation and/or...
Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry.
Eckmann, L, Kagnoff, M F, Fierer, J
Bacterial invasion of mucosal surfaces results in a rapid influx of polymorphonuclear leukocytes. The chemotactic stimulus responsible for this response is not known. Since epithelial cells are among...
Fierer, J, Eckmann, L, Fang, F, Pfeifer, C, Finlay, B B, Guiney, D
Certain serotypes of salmonellae carry virulence plasmids that greatly enhance the pathogenicity of these bacteria in experimentally infected mice. This phenotype is largely attributable to the 8-kb...
Jung, H C, Eckmann, L, Yang, S K, Panja, A, Fierer, J, Morzycka-Wroblewska, E, ...
Pathogenic bacteria that penetrate the intestinal epithelial barrier stimulate an inflammatory response in the adjacent intestinal mucosa. The present studies asked whether colon epithelial cells can...
Huang, G T, Eckmann, L, Savidge, T C, Kagnoff, M F
The acute host response to gastrointestinal infection with invasive bacteria is characterized by an accumulation of neutrophils in the lamina propria, and neutrophil transmigration to the luminal...
Rasmussen, S J, Eckmann, L, Quayle, A J, Shen, L, Zhang, Y X, Anderson, D J, ...
Chlamydia species infect epithelial cells at mucosal surfaces, and are major causes of sexually transmitted diseases. Infection is characterized by inflammation which is exacerbated upon reinfection,...
Eckmann, L, Stenson, W F, Savidge, T C, Lowe, D C, Barrett, K E, Fierer, J, ...
Increased intestinal fluid secretion is a protective host response after enteric infection with invasive bacteria that is initiated within hours after infection, and is mediated by prostaglandin H...
Apoptosis of human intestinal epithelial cells after bacterial invasion.
Kim, J M, Eckmann, L, Savidge, T C, Lowe, D C, Witthöft, T, Kagnoff, M F
Epithelial cells that line the human intestinal mucosa are the initial site of host invasion by bacterial pathogens. The studies herein define apoptosis as a new category of intestinal epithelial...
Cytokine-induced differentiation of IgA B cells: studies using an IgA expressing B-cell lymphoma.
Eckmann, L, Morzycka-Wroblewska, E, Smith, J R, Kagnoff, M F
Cytokines such as interleukin-5 (IL-5) and transforming growth factor beta 1 (TGF beta 1) increase IgA production by heterogeneous populations of lipopolysaccharide (LPS)-activated murine B cells. We...
Schuerer-Maly, C C, Eckmann, L, Kagnoff, M F, Falco, M T, Maly, F E
Cytokines produced by intestinal epithelial cells may function as signals to neighbouring immune and inflammatory cells. We investigated production of the neutrophil and T-lymphocyte chemotactic...
A novel in vitro assay for murine haematopoietic stem cells.
Eckmann, L., Freshney, M., Wright, E. G., Sproul, A., Wilkie, N., Pragnell, I. B.
Study of the biology of haematopoietic stem cells is crucially dependent on the availability of suitable in vitro assays. Existing assays have suffered from the fact that they detect small...