Shotgun sequencing of the human transcriptome with ORF expressed sequence tags (2007)
Dias Neto, E., Correa, R. G., Verjovski-Almeida, S., Briones, M. R., Nagai, M. A., Da Silva, W., Jr., ...
Theoretical considerations predict that amplification of expressed gene transcripts by reverse transcription-PCR using arbitrarily chosen primers will result in the preferential amplification of the...
Functional role of type I and type II interferons in antiviral defense (2007)
Muller, U., Steinhoff, U., Reis, L. F., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., ...
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal...
Reis, L. F., Ruffner, H., Stark, G., Aguet, M., Weissmann, C.
The transcription factor interferon regulatory factor 1 (IRF-1) binds tightly to the interferon (IFN)-beta promoter and has been implicated in the induction of type I IFNs. We generated mice devoid...
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase (2007)
Yang, Y. L., Reis, L. F., Pavlovic, J., Aguzzi, A., Schafer, R., Kumar, A., ...
Double-stranded RNA-dependent protein kinase (PKR) has been implicated in interferon (IFN) induction, antiviral response and tumor suppression. We have generated mice devoid of functional PKR (Pkr%)....
Ruffner, H, Reis, L F, Näf, D, Weissmann, C
Overexpression of interferon regulatory factor 1 (IRF-1) can induce expression of the interferon (IFN) beta gene, at least in certain cells. A role of IRF-1 in the activation of IFN-alpha genes has...
Rezende, S A, Oliveira, V R, Silva, A M, Alves, J B, Goes, A M, Reis, L F
The egg-induced granulomatous reaction in Schistosoma mansoni-infected individuals develops within the portal system of the liver and is the major pathological finding in schistosomiasis. We have...
Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon.
Briken, V, Ruffner, H, Schultz, U, Schwarz, A, Reis, L F, Strehlow, I, ...
Full-scale transcriptional activation of the mouse Gbp genes by gamma interferon (IFN-gamma) requires protein synthesis in embryonic fibroblasts. Although the Gbp-1 and Gbp-2 promoters contain...
Le, J M, Fredrickson, G, Reis, L F, Diamantstein, T, Hirano, T, Kishimoto, T, ...
Recombinant human interleukin 6 (IL-6), also termed B-cell-stimulatory factor 2 (BSF-2) or interferon-beta 2, was found to stimulate the proliferation of mouse thymocytes costimulated with...
Fujita, T, Reis, L F, Watanabe, N, Kimura, Y, Taniguchi, T, Vilcek, J
Nuclear protein IRF-1 (interferon regulatory factor 1) was earlier shown to bind to cis-acting regulatory elements present on interferon (IFN)-alpha/beta genes and some IFN-inducible genes. Here we...
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
Yang, Y L, Reis, L F, Pavlovic, J, Aguzzi, A, Schäfer, R, Kumar, A, ...
Double-stranded RNA-dependent protein kinase (PKR) has been implicated in interferon (IFN) induction, antiviral response and tumor suppression. We have generated mice devoid of functional PKR (Pkr%)....
Reis, L F, Ruffner, H, Stark, G, Aguet, M, Weissmann, C
The transcription factor interferon regulatory factor 1 (IRF-1) binds tightly to the interferon (IFN)-beta promoter and has been implicated in the induction of type I IFNs. We generated mice devoid...
Reis, L F, Harada, H, Wolchok, J D, Taniguchi, T, Vilcek, J
Interferon regulatory factor 1 (IRF-1) is a protein that binds to cis-elements within the promoter of interferon (IFN)-beta and some IFN-inducible genes. We used a human fibroblast line, GM-637, to...
Ruffner, H, Reis, L F, Näf, D, Weissmann, C
Overexpression of interferon regulatory factor 1 (IRF-1) can induce expression of the interferon (IFN) beta gene, at least in certain cells. A role of IRF-1 in the activation of IFN-alpha genes has...
Rezende, S A, Oliveira, V R, Silva, A M, Alves, J B, Goes, A M, Reis, L F
The egg-induced granulomatous reaction in Schistosoma mansoni-infected individuals develops within the portal system of the liver and is the major pathological finding in schistosomiasis. We have...
Interferon regulatory factor 1 is required for mouse Gbp gene activation by gamma interferon.
Briken, V, Ruffner, H, Schultz, U, Schwarz, A, Reis, L F, Strehlow, I, ...
Full-scale transcriptional activation of the mouse Gbp genes by gamma interferon (IFN-gamma) requires protein synthesis in embryonic fibroblasts. Although the Gbp-1 and Gbp-2 promoters contain...
Le, J M, Fredrickson, G, Reis, L F, Diamantstein, T, Hirano, T, Kishimoto, T, ...
Recombinant human interleukin 6 (IL-6), also termed B-cell-stimulatory factor 2 (BSF-2) or interferon-beta 2, was found to stimulate the proliferation of mouse thymocytes costimulated with...
Fujita, T, Reis, L F, Watanabe, N, Kimura, Y, Taniguchi, T, Vilcek, J
Nuclear protein IRF-1 (interferon regulatory factor 1) was earlier shown to bind to cis-acting regulatory elements present on interferon (IFN)-alpha/beta genes and some IFN-inducible genes. Here we...
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
Yang, Y L, Reis, L F, Pavlovic, J, Aguzzi, A, Schäfer, R, Kumar, A, ...
Double-stranded RNA-dependent protein kinase (PKR) has been implicated in interferon (IFN) induction, antiviral response and tumor suppression. We have generated mice devoid of functional PKR (Pkr%)....
Reis, L F, Ruffner, H, Stark, G, Aguet, M, Weissmann, C
The transcription factor interferon regulatory factor 1 (IRF-1) binds tightly to the interferon (IFN)-beta promoter and has been implicated in the induction of type I IFNs. We generated mice devoid...
Reis, L F, Harada, H, Wolchok, J D, Taniguchi, T, Vilcek, J
Interferon regulatory factor 1 (IRF-1) is a protein that binds to cis-elements within the promoter of interferon (IFN)-beta and some IFN-inducible genes. We used a human fibroblast line, GM-637, to...