L. Greiff

Publication List Details

Period

2002 - 2006

Number

26

Co-Authors

A double-blind, randomized, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis (2006)

Wallwork, B., Coman, W., Mackay-Sim, A., Greiff, L., Cervin, A.

Objectives: The antiinflammatory effect of macrolide antibiotics has been well-established, as has their role in the treatment of certain disorders of chronic airway inflammation. Several studies...

Challenge-induced plasma exudation and mucinous secretion in human airways (2005)

Greiff, L, Andersson, M, Coman, WB, Lindberg, H, Marko-Varga, G, Wallwork, B, ...

Secretion of mucins and exudation of plasma are distinct processes of importance to innate immunity and inflammatory disease. Yet, little is known about their relation in human airways. The objective...

Secretoneurin is released into human airways by topical histamine but not capsaicin (2005)

Korsgren, M, Fischer-Colbrie, R, Andersson, M, Coman, WB, Mackay-Sim, A, Persson, CG, ...

Background: The neuropeptide secretoneurin, with potential relevance to leukocyte trafficking, is present in nerves of the nasal mucosa in allergic rhinitis and may be released in response to...

Clearance of 99mTc DTPA from guinea pig nasal, tracheobronchial, and bronchoalveolar airways.

Greiff, L, Wollmer, P, Erjefält, I, Pipkorn, U, Persson, C G

Technetium-99m labelled diethylenetriamine penta-acetate (99mTc-DTPA) was used to compare small solute absorption (clearance) from nasal, tracheobronchial, and bronchoalveolar airways in...

Absorption of 51Cr EDTA across the human nasal airway barriers in the presence of topical histamine.

Greiff, L, Wollmer, P, Pipkorn, U, Persson, C G

Whether histamine, a mediator that causes exudation, affects the airway absorption of luminal solutes has been examined in a study of eight healthy volunteers. Fluid containing the absorption tracer...

Effects of histamine, ethanol, and a detergent on exudation and absorption across guinea pig airway mucosa in vivo.

Greiff, L, Erjefält, I, Wollmer, P, Pipkorn, U, Persson, C G

This study examined effects of three substances that cause mucosal provocation (histamine, ethanol, and the detergent dioctylsodium sulphosuccinate (DOSS] on the flux of solutes across airway...

Effect of seasonal allergic rhinitis on airway mucosal absorption of chromium-51 labelled EDTA.

Greiff, L, Wollmer, P, Svensson, C, Andersson, M, Persson, C G

BACKGROUND--Hyperpermeability of the airway mucosa is thought to be characteristic of allergic rhinitis and asthma. Nine subjects with seasonal rhinitis caused by birch pollen were studied and the...

Effects of nicotine on the human nasal mucosa.

Greiff, L, Wollmer, P, Erjefält, I, Andersson, M, Pipkorn, U, Persson, C G

BACKGROUND--Topical application of nicotine and stimulation of tachykinin containing sensory nerves have been shown to produce mucosal exudation of plasma and derangement of the epithelial lining in...

Microvascular exudative hyperresponsiveness in human coronavirus-induced common cold.

Greiff, L, Andersson, M, Akerlund, A, Wollmer, P, Svensson, C, Alkner, U, ...

BACKGROUND--The inflammatory response of the airway microcirculation in rhinitis and asthma may be recorded as luminal entry of plasma macromolecules (mucosal exudation). This study examines the...

Effects of topical capsaicin in seasonal allergic rhinitis.

Greiff, L, Svensson, C, Andersson, M, Persson, C G

BACKGROUND--Mucosal exudation (luminal entry) of bulk plasma is a key feature of airway defence and inflammation. In guinea pig and rat airways this response is readily produced by neurogenic...

Demonstration of bronchial eosinophil activity in seasonal allergic rhinitis by induced plasma exudation combined with induced sputum

Greiff, L., Andersson, M., Svensson, C., Linden, M., Wollmer, P., Persson, C.

BACKGROUND—Patients with seasonal allergic rhinitis may develop bronchial hyperresponsiveness during the active disease period. Eosinophil activation may occur in the bronchial mucosa and may be...

Degranulation patterns of eosinophil granulocytes as determinants of eosinophil driven disease

Erjefalt, J, Greiff, L, Andersson, M, Adelroth, E, Jeffery, P, Persson, C

BACKGROUND—Degranulation of eosinophils in target tissues is considered a key pathogenic event in major chronic eosinophilic diseases. However, because of a lack of appropriate methods, little is...

Effects of inhaled histamine, methacholine and capsaicin on sputum levels of alpha 2-macroglobulin

Halldorsdottir, H., Greiff, L., Wollmer, P., Andersson, M., Svensson, C., Alkner, U., ...

BACKGROUND: Plasma exudation-derived proteins and peptides contribute significantly to inflammation in the airway mucosa in vivo. In the guinea pig trachea both histamine and the neurogenic stimulant...

Allergic Rhinoconjunctivitis: the Role of Histamine

Andersson, M., Greiff, L., Svensson, C.

Allergic rhinoconjunctivitis is the most common atopic condition encountered in clinical practice. Analysis of the pathogenesis of this condition permits identification of optimal therapeutic...