Research article - Comet 81P/Wild 2 under a microscope (2006)
Brownlee, D., Tsou, P., Aleon, J., Alexander, C. M. O., Araki, T., Bajt, S., ...
Mineralogy and Petrology of Comet Wild 2 Nucleus Samples. (2006)
Zolensky, M.E., Zega, T.J., Yano, H., Wirick, S., Westphal, A.J., Weisberg, M.K., ...
Comet 81P/Wild 2 under a microscope (2006)
Brownlee, D., Tsou, P., Aleon, J., Alexander, C. M. O., Araki, T., Bajt, S., ...
Open DMIX: High Performance Web Services for (2004)
Robert Grossman, Chetan Gupta, Parthasarathy Krishnaswamy, L. Grossman, Yunhong Gu, David Hanley, ...
In this note, we introduce Open DMIX, an open source collection of web services for the mining, integration, and exploration of remote and distributed data. We also describe some preliminary...
Bialgebras and Realizations (2004)
R. L. Grossman, R. G. Larson, This Robert, L. Grossman, Stefan Catoiu, William Chin
this paper we consider when a linear functional on a bialgebra is realized by the action of the bialgebra on a finite object. This depends on whether the action of the bialgebra on the functional is...
Data Mining and Tree-based Optimization (2003)
H. Bodek, R. L. Grossman, H. V. Poor, This Robert, L. Grossman, Haim Bodek
Consider a large collection of objects, each of which has a large number of attributes of several di#erent sorts. We assume that there are data attributes representing data, attributes which are to...
DiMeo, Robert V., Mullany, T. C., Tedford, A., Grossman, L.
The results of the DARC/NAS (HOST) bi-directional interface testing are described in this report. The DARC and NAS systems were physically connected by the General Purpose Output (GPO)/General...
Molecular aspects of DNA repair. (1987)
Friedberg, E.C., Backendorf, C., Burke, J., Collins, A., Grossman, L., Hoeijmakers, J.H.J., ...
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DNA repair and aging in basal cell carcinoma: a molecular epidemiology study.
Wei, Q, Matanoski, G M, Farmer, E R, Hedayati, M A, Grossman, L
This molecular epidemiology study examines the DNA-repair capacities (DRCs) of basal cell carcinoma (BCC) skin cancer patients (88) and their controls (135) by using a plasmid/host-cell reactivation...
ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB.
Koo, H S, Claassen, L, Grossman, L, Liu, L F
The helicase action of the Escherichia coli UvrAB complex on a covalently closed circular DNA template was monitored using bacterial DNA topoisomerase I, which specifically removes negative...
Lin, C G, Kovalsky, O, Grossman, L
The entire process of nucleotide excision repair (NER) in Escherichia coli has been reconstituted in vitro from purified proteins and defined DNA substrates. However, how this system is organized in...
One form of nucleotide excision repair (NER) is known to be functionally coupled to transcription, but the nature of this functional link in Escherichia coli is still unclear. Here we have employed...
Gribble, M J, Chow, A W, Naiman, S C, Smith, J A, Bowie, W R, Sacks, S L, ...
Piperacillin as a single agent was compared in a prospective randomized trial with carboxypenicillin-aminoglycoside combinations in empirical therapy of serious bacterial infections. The difference...
Mutations in the Escherichia coli UvrB ATPase motif compromise excision repair capacity.
The Escherichia coli UvrB protein possesses an amino acid sequence motif common to many ATPases. The role of this motif in UvrB has been investigated by site-directed mutagenesis. Three UvrB mutants,...
Helicase properties of the Escherichia coli UvrAB protein complex.
The Escherichia coli UvrA protein has an associated ATPase activity with a turnover number affected by the presence of UvrB protein as well as by DNA. Specifically, the structure of DNA significantly...
The purification of the Escherichia coli UvrABC incision system.
Yeung, A T, Mattes, W B, Oh, E Y, Yoakum, G H, Grossman, L
The UvrA, UvrB and UvrC proteins of Escherichia coli have been purified in good yields to homogeneity with rapid three- or four-step purification procedures. The cloned uvrA and uvrB genes were...
The effect of Escherichia coli Uvr protein binding on the topology of supercoiled DNA.
The effects of the binding of the E. coli UvrA and UvrB proteins on the linking number (delta L) of superhelical DNA has been measured. The effects of cofactor ATP structure on UvrAB-nucleoprotein...
ATPase activity of the UvrA and UvrAB protein complexes of the Escherichia coli UvrABC endonuclease.
Oh, E Y, Claassen, L, Thiagalingam, S, Mazur, S, Grossman, L
We have analyzed the ATPase activity exhibited by the UvrABC DNA repair complex. The UvrA protein is an ATPase whose lack of DNA dependence may be related to the ATP induced monomer-dimer...
Hansson, J, Grossman, L, Lindahl, T, Wood, R D
A newly developed cell-free system was used to study DNA repair synthesis carried out by extracts from human cell lines in vitro. Extracts from a normal human lymphoid cell line and from cell lines...
Incision of damaged versus nondamaged DNA by the Escherichia coli UvrABC proteins.
Incision of damaged DNA by the Escherichia coli UvrABC endonuclease requires the UvrA, UvrB, and UvrC proteins as well as ATP hydrolysis. This incision reaction can be divided into three steps: site...
Involvement of a cryptic ATPase activity of UvrB and its proteolysis product, UvrB* in DNA repair.
The incision of damaged DNA by the Escherichia coli UvrABC endonuclease requires ATP hydrolysis. Although the deduced sequence of the UvrB protein suggests a putative ATP binding site, no nucleoside...
Potential role of proteolysis in the control of UvrABC incision.
UvrB is specifically proteolyzed in Escherichia coli cell extracts to UvrB*. UvrB* is capable of interacting with UvrA in an apparently similar manner to the UvrB, however UvrB* is defective in the...
Yeung, A T, Mattes, W B, Grossman, L
An examination has been made into the nature of the nucleoprotein complexes formed during the incision reaction catalyzed by the Escherichia coli UvrABC endonuclease when acting on a pyrimidine...
Yoakum, G H, Yeung, A T, Mattes, W B, Grossman, L
We have constructed a hybrid pKC30-uvrA plasmid (pGHY5003) in which transcription of the uvrA gene can be induced under pL control to amplify the uvrA gene product to 7% of cellular protein. To...
Enzymatic properties of purified Escherichia coli uvrABC proteins.
Yeung, A T, Mattes, W B, Oh, E Y, Grossman, L
The cloned uvrA and uvrB genes of Escherichia coli K-12 were amplified by linkage to the PL promoter of plasmid pKC30. The uvrC gene was amplified in the high-copy-number plasmid pRLM 24. The three...
Caron, P R, Kushner, S R, Grossman, L
The bimodal-incision nature of the reaction of UV-irradiated DNA catalyzed by the Escherichia coli uvrABC protein complex potentially leads to excision of a 12- to 13-nucleotide-long damaged...
Measurement of DNA repair deficiency in workers exposed to benzene.
Hallberg, L M, El Zein, R, Grossman, L, Au, W W
We hypothesize that chronic exposure to environmental toxicants can induce genetic damage causing DNA repair deficiencies and leading to the postulated mutator phenotype of carcinogenesis. To test...
Epidemiology of ultraviolet-DNA repair capacity and human cancer.
The following conclusions are derived from an epidemiological study. Reduced repair of ultraviolet (UV)-induced DNA damage contributes directly to basal cell carcinoma (BCC) in individuals with prior...
DNA repair and aging in basal cell carcinoma: a molecular epidemiology study.
Wei, Q, Matanoski, G M, Farmer, E R, Hedayati, M A, Grossman, L
This molecular epidemiology study examines the DNA-repair capacities (DRCs) of basal cell carcinoma (BCC) skin cancer patients (88) and their controls (135) by using a plasmid/host-cell reactivation...
ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB.
Koo, H S, Claassen, L, Grossman, L, Liu, L F
The helicase action of the Escherichia coli UvrAB complex on a covalently closed circular DNA template was monitored using bacterial DNA topoisomerase I, which specifically removes negative...
Lin, C G, Kovalsky, O, Grossman, L
The entire process of nucleotide excision repair (NER) in Escherichia coli has been reconstituted in vitro from purified proteins and defined DNA substrates. However, how this system is organized in...
One form of nucleotide excision repair (NER) is known to be functionally coupled to transcription, but the nature of this functional link in Escherichia coli is still unclear. Here we have employed...
Gribble, M J, Chow, A W, Naiman, S C, Smith, J A, Bowie, W R, Sacks, S L, ...
Piperacillin as a single agent was compared in a prospective randomized trial with carboxypenicillin-aminoglycoside combinations in empirical therapy of serious bacterial infections. The difference...
Mutations in the Escherichia coli UvrB ATPase motif compromise excision repair capacity.
The Escherichia coli UvrB protein possesses an amino acid sequence motif common to many ATPases. The role of this motif in UvrB has been investigated by site-directed mutagenesis. Three UvrB mutants,...
Helicase properties of the Escherichia coli UvrAB protein complex.
The Escherichia coli UvrA protein has an associated ATPase activity with a turnover number affected by the presence of UvrB protein as well as by DNA. Specifically, the structure of DNA significantly...
The purification of the Escherichia coli UvrABC incision system.
Yeung, A T, Mattes, W B, Oh, E Y, Yoakum, G H, Grossman, L
The UvrA, UvrB and UvrC proteins of Escherichia coli have been purified in good yields to homogeneity with rapid three- or four-step purification procedures. The cloned uvrA and uvrB genes were...
The effect of Escherichia coli Uvr protein binding on the topology of supercoiled DNA.
The effects of the binding of the E. coli UvrA and UvrB proteins on the linking number (delta L) of superhelical DNA has been measured. The effects of cofactor ATP structure on UvrAB-nucleoprotein...
ATPase activity of the UvrA and UvrAB protein complexes of the Escherichia coli UvrABC endonuclease.
Oh, E Y, Claassen, L, Thiagalingam, S, Mazur, S, Grossman, L
We have analyzed the ATPase activity exhibited by the UvrABC DNA repair complex. The UvrA protein is an ATPase whose lack of DNA dependence may be related to the ATP induced monomer-dimer...
Hansson, J, Grossman, L, Lindahl, T, Wood, R D
A newly developed cell-free system was used to study DNA repair synthesis carried out by extracts from human cell lines in vitro. Extracts from a normal human lymphoid cell line and from cell lines...
Incision of damaged versus nondamaged DNA by the Escherichia coli UvrABC proteins.
Incision of damaged DNA by the Escherichia coli UvrABC endonuclease requires the UvrA, UvrB, and UvrC proteins as well as ATP hydrolysis. This incision reaction can be divided into three steps: site...
Involvement of a cryptic ATPase activity of UvrB and its proteolysis product, UvrB* in DNA repair.
The incision of damaged DNA by the Escherichia coli UvrABC endonuclease requires ATP hydrolysis. Although the deduced sequence of the UvrB protein suggests a putative ATP binding site, no nucleoside...
Potential role of proteolysis in the control of UvrABC incision.
UvrB is specifically proteolyzed in Escherichia coli cell extracts to UvrB*. UvrB* is capable of interacting with UvrA in an apparently similar manner to the UvrB, however UvrB* is defective in the...
Yeung, A T, Mattes, W B, Grossman, L
An examination has been made into the nature of the nucleoprotein complexes formed during the incision reaction catalyzed by the Escherichia coli UvrABC endonuclease when acting on a pyrimidine...
Yoakum, G H, Yeung, A T, Mattes, W B, Grossman, L
We have constructed a hybrid pKC30-uvrA plasmid (pGHY5003) in which transcription of the uvrA gene can be induced under pL control to amplify the uvrA gene product to 7% of cellular protein. To...
Enzymatic properties of purified Escherichia coli uvrABC proteins.
Yeung, A T, Mattes, W B, Oh, E Y, Grossman, L
The cloned uvrA and uvrB genes of Escherichia coli K-12 were amplified by linkage to the PL promoter of plasmid pKC30. The uvrC gene was amplified in the high-copy-number plasmid pRLM 24. The three...
Caron, P R, Kushner, S R, Grossman, L
The bimodal-incision nature of the reaction of UV-irradiated DNA catalyzed by the Escherichia coli uvrABC protein complex potentially leads to excision of a 12- to 13-nucleotide-long damaged...
Measurement of DNA repair deficiency in workers exposed to benzene.
Hallberg, L M, El Zein, R, Grossman, L, Au, W W
We hypothesize that chronic exposure to environmental toxicants can induce genetic damage causing DNA repair deficiencies and leading to the postulated mutator phenotype of carcinogenesis. To test...
Epidemiology of ultraviolet-DNA repair capacity and human cancer.
The following conclusions are derived from an epidemiological study. Reduced repair of ultraviolet (UV)-induced DNA damage contributes directly to basal cell carcinoma (BCC) in individuals with prior...
Disseminated intravascular coagulation in acute monoblastic leukemia: response to heparin therapy.
Mangal, A. K., Grossman, L., Vickars, L.
A 27-year-old man with acute monoblastic leukemia had clinical and laboratory evidence of disseminated intravascular coagulation (DIC), which was exacerbated by induction chemotherapy. Heparin...