Scientific Commons: L. H.

Postconditioning for protection of the infarcting heart. (2006)

Yellon,
D.M.,
Opie,
L.H.

A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli. (2006)

Ioannou,
Y.,
Giles,
I.,
Lambrianides,
A.,
...

Late-onset episodic ataxia type 2 due to an in-frame insertion in CACNA1A (2005)

Imbrici,
P.,
Eunson,
L.H.,
Graves,
T.D.,
...

New calcium channel mutations predict aberrant RNA splicing in episodic ataxia (2005)

Eunson,
L.H.,
Graves,
T.D.,
Hanna,
M.G.

New phenotypic diversity associated with the mitochondrial tRNA(Ser(UCN)) gene mutation (2005)

Pulkes,
T.,
Liolitsa,
D.,
Eunson,
L.H.,
...

Postconditioning: a simple, clinically applicable procedure to improve revascularization in acute myocardial infarction (2005)

Vinten-Johansen,
J.,
Yellon,
D.M.,
Opie,
L.H.

New phenotypic diversity associated with the mitochondrial tRNA (Ser(UCN)) gene mutation (2005)

Pulkes,
T.,
Liolitsa,
D.,
Eunson,
L.H.,
...

We performed detailed clinical, histopathological, biochemical, in vitro translation and molecular genetic analysis in patients from two unrelated families harbouring the tRNA(Ser(UCN))...

Hearing loss treated with pamidronate (2005)

Murdin,
L.,
Yeoh,
L.H.

Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-reactivity by an autoantibody (2005)

Kumar,
S.,
Nagl,
S.,
Kalsi,
J.K.,
...

We have recently shown that the anti-cardiolipin activity of human anti-phospholipid antibody UK4 (lambda) resides on its heavy chain. We now show that UK4 possesses strong reactivity to the...

Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV (2005)

Kumar,
S.,
Bunting,
K.A.,
Kalsi,
J.,
...

Cognitive vulnerability in subgroups of MND (2005)

Wicks,
P.,
Abrahams,
S.,
Papps,
B.,
...

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data (2005)

Khan,
N.L.,
Jain,
S.,
Lynch,
J.M.,
...

Diltiazem-induced neuroprotection in glutamate excitotoxicity and ischemic insult of retinal neurons (2005)

Vallazza-Deschamps,
G.,
Fuchs,
C.,
Cia,
D.,
...

PURPOSE: Cell death is often related to an abnormal increase in Ca(2+) flux. In the retina, Ca(2+) channels are mainly from the L-type that do not inactivate with time. Under excitotoxic and ischemic...

Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors (2005)

Vallazza-Deschamps,
G.,
Cia,
D.,
Gong,
J.,
...

In different animal models, photoreceptor degeneration was correlated to an abnormal increase in cGMP concentration. The cGMP-induced photoreceptor toxicity was demonstrated by applying the...

Advanced glycation end products can induce glial reaction and neuronal degeneration in retinal explants (2005)

Lecleire-Collet,
A.,
Tessier,
L.H.,
Massin,
P.,
...

BACKGROUND/AIMS: Neuronal degeneration has been reported to occur in diabetic retinopathy before the onset of detectable microvascular abnormalities. To investigate whether advanced glycation end...

Retinal-cell-conditioned medium prevents TNF-alpha-induced apoptosis of purified ganglion cells (2005)

Fuchs,
C.,
Forster,
V.,
Balse,
E.,
...

PURPOSE: Retinal ischemic processes occurring in glaucoma or diabetic retinopathy induce the secretion of tumor necrosis factor (TNF)-alpha. This cytokine was reported to be either toxic to or...

Crystal structure of tobacco etch virus protease shows the protein C terminus bound within the active site (2005)

Nunn,
C.M.,
Jeeves,
M.,
Cliff,
M.J.,
...

Dysfunction of the brain calcium channel CaV2.1 in absence epilepsy and episodic ataxia (2004)

Imbrici,
P.,
Jaffe,
S.L.,
Eunson,
L.H.,
...

Expanding the phenotype of potassium channelopathy: severe neuromyotonia and skeletal deformities without prominent Episodic Ataxia (2004)

Kinali,
M.,
Jungbluth,
H.,
Eunson,
L.H.,
...

Influence of sympathetic autonomic arousal on cortical arousal: implications for a therapeutic behavioural intervention in epilepsy (2004)

Nagai,
Y.,
Goldstein,
L.H.,
Critchley,
H.D.,
...

The effect of image colour distortion on evaluation of donor liver suitability for transplantation (2004)

De Cunha,
D.A.,
Eadie,
L.H.,
Barbur,
J.L.,
...

Some medical applications rely on the use of colour in the diagnostic process, even when poor colour reproduction can affect diagnosis. In this paper, we investigate the effect colour distortion can...

The large-conductance Ca2+-activated K+ channel is essential for innate immunity. (2004)

Ahluwalia,
J.,
Tinker,
A.,
Clapp,
L.H.,
...

How many camels are there in Italy? Cognitive estimates standardised on the Italian population. (2003)

Della Sala,
S.,
MacPherson,
S.E.,
Phillips,
L.H.,
...

Exploring potential correlates of neuropsychological impairment in sporadic and familial MND (2003)

Wicks,
P.,
Abrahams,
S.,
Papps,
B.,
...

Possible roles for IGF-I splice variants in the myometrium during pregnancy and following parturition (2003)

Randall,
L.H.,
Hameed,
M.,
Beech,
S.,
...

Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A (2003)

Cui,
Y.,
Tinker,
A.,
Clapp,
L.H.

1. We investigated the mechanism of action of two novel nonsulphonylurea ATP-sensitive potassium channel (K(ATP)) inhibitors, PNU-99963 and PNU-37883A, on four types of cloned K(ATP) channels. 2....

Variable K+ channel subunit dysfunction in inherited mutations of KCNA1 (2002)

Rea,
R.,
Spauschus,
A.,
Eunson,
L.H.,
...

Assembly limits the pharmacological complexity of ATP-sensitive potassium channels (2002)

Giblin,
J.P.,
Cui,
Y.,
Clapp,
L.H.,
...

ATP-sensitive potassium channels (K(ATP) channels) are formed from an octameric complex of an inwardly rectifying K(+) channel (Kir6.1, Kir6.2) and a sulfonylurea receptor (SUR1, SUR2A, and SUR2B)....

The molecular composition of KATP channels in human pulmonary artery smooth muscle cells and their modulation by growth (2002)

Cui,
Y.,
Tran,
S.,
Tinker,
A.,
...

Multiple types of ATP-sensitive potassium (K(ATP)) channels have been described in smooth muscle, including those inhibited by ATP and those activated by nucleotide diphosphate (K(NDP)). The...

Human epilepsy associated with dysfunction of the brain P/Q- type calcium channel (2001)

Jouvenceau,
A.,
Eunson,
L.H.,
Spauschus,
A.,
...

Sodium channel gene mutations in hypokalemic periodic paralysis: An uncommon cause in the UK (2001)

Davies,
N.P.,
Eunson,
L.H.,
Samuel,
M.,
...

Angiotensin-converting enzyme inhibition enhances a subthreshold stimulus to elicit delayed preconditioning in pig myocardium (2001)

Jaberansari,
M.T.,
Baxter,
G.F.,
Muller,
C.A.,
...

OBJECTIVES: We assessed the effect of angiotensin-converting enzyme (ACE) inhibition in combination with a subthreshold preconditioning (PC) stimulus to elicit delayed preconditioning against...

Temporal variation in endotoxin-induced vascular hyporeactivity in a rat mesenteric artery organ culture model (2001)

O'Brien,
A.J.,
Wilson,
A.J.,
Sibbald,
R.,
...

Endotoxin-induced vascular hyporeactivity to phenylephrine (PE) is well described in rodent aorta, but has not been investigated in smaller vessels in vitro. Segments of rat superior mesenteric...

Clinical, electrophysiological, and molecular genetic studies in a new family with paramyotonia congenita (2000)