Orie, N.N., Fry, C.H., Clapp, L.H.
Objective: We investigated the role of the inward rectifier potassium (KIR) channel and the cyclic AMP-dependent pathway in mediating vasorelaxation induced by the prostacyclin analogue cicaprost....
Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide (2005)
Singer, M., Coluzzi, F., O'Brien, A., Clapp, L.H.
We describe three critically ill patients who received drugs with KATP channel-opening properties and subsequently developed severe life-threatening complications, including hyperkalaemia and...
Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide (2005)
Singer, M., Coluzzi, F., O'Brien, A., Clapp, L.H.
We describe three critically ill patients who received drugs with KATP channel-opening properties and subsequently developed severe life-threatening complications, including hyperkalaemia and...
The large-conductance Ca2+-activated K+ channel is essential for innate immunity (2004)
Ahluwalia, J., Tinker, A., Clapp, L.H., Duchen, M.R., Abramov, A.Y., Pope, S., ...
Neutrophil leukocytes have a pivotal function in innate immunity. Dogma dictates that the lethal blow is delivered to microbes by reactive oxygen species (ROS) and halogens1, 2, products of the NADPH...
The large-conductance Ca2+ -activated K+ channel is essential for innate immunity (2004)
Ahluwalia, J., Tinker, A., Clapp, L.H., Duchen, M.R., Abramov, A.Y., Pope, S., ...
Neutrophil leukocytes have a pivotal function in innate immunity. Dogma dictates that the lethal blow is delivered to microbes by reactive oxygen species (ROS) and halogens1, 2, products of the NADPH...
Quinn, K.V., Cui, Y., Giblin, J.P., Clapp, L.H., Tinker, A.
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second...
Clapp, L.H., Finney, P., Turcato, S., Tran, S., Rubin, L.J., Tinker, A.
Primary pulmonary hypertension is characterized by increased pulmonary vascular resistance and smooth muscle proliferation. Stable analogs are increasingly being used to treat this disease, although...
Cui, Y., Giblin, J.P., Clapp, L.H., Tinker, A.
ATP-sensitive potassium channels are an octomeric complex of four pore-forming subunits of the Kir 6.0 family and four sulfonylurea receptors. The Kir 6.0 family consists of two known members, Kir...
Acetylcholine increases voltage-activated Ca2+ current in freshly dissociated smooth muscle cells.
Clapp, L H, Vivaudou, M B, Walsh, J V, Singer, J J
The regulation of voltage-activated Ca2+ current by acetylcholine was studied in single freshly dissociated smooth muscle cells from the stomach of the toad Bufo marinus by using the tight-seal...
The effects of noradrenaline and of raised external potassium ([K+]o) on the efflux of 86Rb or 42K and on tension were studied in preparations taken from eight different arteries under various...
Acetylcholine increases voltage-activated Ca2+ current in freshly dissociated smooth muscle cells.
Clapp, L H, Vivaudou, M B, Walsh, J V, Singer, J J
The regulation of voltage-activated Ca2+ current by acetylcholine was studied in single freshly dissociated smooth muscle cells from the stomach of the toad Bufo marinus by using the tight-seal...
The effects of noradrenaline and of raised external potassium ([K+]o) on the efflux of 86Rb or 42K and on tension were studied in preparations taken from eight different arteries under various...
O'Brien, A J, Wilson, A J, Sibbald, R, Singer, M, Clapp, L H
Endotoxin-induced vascular hyporeactivity to phenylephrine (PE) is well described in rodent aorta, but has not been investigated in smaller vessels in vitro.Segments of rat superior mesenteric artery...
Evans, A. M., Clapp, L. H., Gurney, A. M.
Elevation of intracellular ATP levels by flash photolysis of caged ATP augmented the delayed rectifier K-current (IKDR) in rabbit pulmonary artery myocytes. The percentage augmentation was unaffected...
Endothelial-dependent relaxant actions of carbachol and substance P in arterial smooth muscle.
In helical strips cut from the small mesenteric artery of guinea-pig (GPSMA) (0.3-0.6 mm o.d.) relaxations induced by substance P were more susceptible to damage of the endothelium by rubbing than...