Molecular determinants of treatment response in human germ cell tumors (2003)
Mayer, F., Stoop, H., Scheffer, G.L., Scheper, R., Oosterhuis, J.W., Looijenga, L.H., ...
PURPOSE: Germ cell tumors (GCTs) are highly sensitive to cisplatin-based chemotherapy. This feature is unexplained, as is the intrinsic chemotherapy resistance of mature teratomas and the resistant...
POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors (2003)
Looijenga, L.H., Gouveia Brazao, C.A. De, Kononen, J., Gillis, A.J., Roozendaal, K.E. Van, Zoelen, E.J. Van, ...
Human germ cell tumors (GCTs) may have variable histology and clinical behavior, depending on factors such as sex of the patient, age at clinical diagnosis, and anatomical site of the tumor. Some...
Looijenga, L.H., Gurp, R.J. Van, Nesland, J.M., Stoop, H., Gillis, A.J., Gouveia Brazao, C.A. De, ...
Testicular germ-cell tumors (TGCTs) of adolescents and adults originate from intratubular germ cell neoplasia (ITGCN), which is composed of the malignant counterparts of embryonal germ cells. ITGCN...
Zafarana, G., Gillis, A.J., Gurp, R.J. Van, Olsson, P.G., Elstrodt, F., Stoop, H., ...
Seminomas and nonseminomas represent the invasive stages of testicular (TGCTs) of adolescents and adults. Although TGCTs are characterized by extra copies of the short arm of chromosome 12, the...
Mayer, F., Gillis, A.J., Dinjens, W., Oosterhuis, J.W., Bokemeyer, C., Looijenga, L.H.
Systemic cisplatin-based chemotherapy cures > or =90% of patients with metastatic germ cell tumors (GCTs). The biological basis of this exquisite chemo-sensitivity and the resistant phenotype...
Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis (2000)
Roelofs, H., Oosterhuis, J.W., Looijenga, L.H., Bokemeyer, C., Mostert, M.C., Pompe, K., ...
Human testicular germ-cell tumors of young adults (TGCTs), both seminomas and nonseminomas, are characterized by 12p overrepresentation, mostly as isochromosomes, of which the biological and clinical...
Heterogeneous X inactivation in trophoblastic cells of human full-term female placentas (1999)
Looijenga, L.H., Gillis, A.J., Verkerk, A.J., Putten, W.L. Van, Oosterhuis, J.W.
In female mammalian cells, one of the two X chromosomes is inactivated to compensate for gene-dose effects, which would be otherwise doubled compared with that in male cells. In somatic lineages in...
Roelofs, H., Gurp, R.J. Van, Oosterhuis, J.W., Looijenga, L.H.
Testicular germ cell tumors (TGCTs) of adolescents and adults have been shown to contain proteins of the human endogenous retrovirus type K family. In a recent study, expression of these retroviral...
Mosselman, S, Looijenga, L H, Gillis, A J, Van Rooijen, M A, Kraft, H J, Van Zoelen, E J, ...
Testicular germ cell tumors are the most common form of cancer in young adult males. They result from a derangement of primordial germ cells, and they grow out from a noninvasive carcinoma-in-situ...
Heterogeneous X inactivation in trophoblastic cells of human full-term female placentas.
Looijenga, L H, Gillis, A J, Verkerk, A J, Van Putten, W L, Oosterhuis, J W
In female mammalian cells, one of the two X chromosomes is inactivated to compensate for gene-dose effects, which would be otherwise doubled compared with that in male cells. In somatic lineages in...
Mosselman, S, Looijenga, L H, Gillis, A J, Van Rooijen, M A, Kraft, H J, Van Zoelen, E J, ...
Testicular germ cell tumors are the most common form of cancer in young adult males. They result from a derangement of primordial germ cells, and they grow out from a noninvasive carcinoma-in-situ...
Heterogeneous X inactivation in trophoblastic cells of human full-term female placentas.
Looijenga, L H, Gillis, A J, Verkerk, A J, Van Putten, W L, Oosterhuis, J W
In female mammalian cells, one of the two X chromosomes is inactivated to compensate for gene-dose effects, which would be otherwise doubled compared with that in male cells. In somatic lineages in...
X inactivation in human testicular tumors. XIST expression and androgen receptor methylation status.
Looijenga, L. H., Gillis, A. J., Van Gurp, R. J., Verkerk, A. J., Oosterhuis, J. W.
In female mammalian cells, inactivation of one of the X chromosomes compensates the increased dosage of X-linked genes as compared with their male counterparts. This process is initiated by the...