Rogers, H.J., Bradbrook, I.D., Morrison, P.J., Spector, R.G., Cox, D.A., Lees, L.J.
Sultamicillin is an orally absorbed double ester of sulbactam (penicillanic acid sulphone, a semisynthetic inhibitor of the &eegr;-lactamases of many Gram-positive and Gram-negative species) and...
Pharmacokinetics of alafosfalin, alone and in combination with cephalexin, in humans.
Alafosfalin is a phosphonodipeptide with significant activity as an antibacterial agent and as a potentiator of beta-lactam antibiotics. Studies in humans showed that oral doses of 50 to 2,500 mg...
Pharmacokinetics of alafosfalin, alone and in combination with cephalexin, in humans.
Alafosfalin is a phosphonodipeptide with significant activity as an antibacterial agent and as a potentiator of beta-lactam antibiotics. Studies in humans showed that oral doses of 50 to 2,500 mg...
Devenport, M H, Crook, D, Wynn, V, Lees, L J
1. Azole antifungal agents such as ketoconazole act by inhibiting cytochrome P-450 mediated sterol synthesis in the fungal cell membrane and thus have the potential to interfere with mammalian...
Biliary excretion of amoxycillin and ceftriaxone after intravenous administration in man.
Maudgal, D P, Maxwell, J D, Lees, L J, Wild, R N
1 Plasma and biliary concentrations of amoxycillin and ceftriaxone were measured after bolus intravenous administration (500 mg) in four subjects with normal hepato-biliary and renal function. 2 The...