A structural and catalytic model for zinc phosphoesterases (2008)
Buchholz, R.R., Etienne, M.E., Dorgelo, A., Mirams, R.E., Smith. S.J., Chow, S.Y., ...
Smith, S. J., Casellato, A., Hadler, K. S., Mitic, N., Riley, M. J., Bortoluzzi, A. J., ...
Purple acid phosphatase from pig uterine fluid (uteroferrin), a representative of the diverse family of binuclear metallohydrolases, requires a heterovalent Fe(III)Fe(II) center for catalytic...
Diesterase activity and substrate binding in purple acid phosphatases (2007)
Cox, R. S., Schenk, G., Mitic, N., Gahan, L. R., Hengge, A. C.
The purple acid phosphatases (PAPs) are bimetallophosphatases that are reported to lack phosphodiesterase activity based on the absence of reactivity with bis(p-nitrophenyl) phosphate. Yet, model...
Copper(II) Coordination Chemistry of Cyclic Peptides (2007)
Van Den Brenk, A. L., Seibold, B., Gahan, L. R., Comba, P., Hanson, G. R.
Diesterase activity and substrate binding in purple acid phosphatases (2007)
Cox, R. S., Schenk, G., Mitic, N., Gahan, L. R., Hengge, A. C.
The purple acid phosphatases (PAPs) are bimetallophosphatases that are reported to lack phosphodiesterase activity based on the absence of reactivity with bis(p-nitrophenyl) phosphate. Yet, model...
Smith, S. J., Casellato, A., Hadler, K. S., Mitic, N., Riley, M. J., Bortoluzzi, A. J., ...
Purple acid phosphatase from pig uterine fluid (uteroferrin), a representative of the diverse family of binuclear metallohydrolases, requires a heterovalent Fe(III)Fe(II) center for catalytic...
Copper(II) Coordination Chemistry of Cyclic Peptides (2007)
Van Den Brenk, A. L., Seibold, B., Gahan, L. R., Comba, P., Hanson, G. R.
Surface-Functionalized Polymer Nanoparticles for Selective Sequestering of Heavy Metals (2006)
C. A. Bell, S. V. Smith, M. R. Whittaker, A. K. Whittaker, L. R. Gahan, M. J. Monteiro
This is the highest impact factor journal (8.078) for Material Science. The work involves the synthesis of polymer nanoparticles with functional surfaces and polymer chemical composition for...
Biomimetics and a derivative of pig purple acid phosphatase with FeIIINiII binuclear centres (2006)
Herrald, P. R., Drew, S. C., Neves, A., Murray, R., Moubaraki, B., Mitic, N, ...
Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism (2006)
Elliott, T. W., Mitic, N., Gahan, L. R., Guddat, L. W., Schenk, G.
Purple acid phosphatases (PAPs) belong to the family of binuclear metallohydrolases and catalyse the hydrolysis of a large group of phosphoester substrates at acidic pH. Despite structural...
Surface-Functionalized Polymer Nanoparticles for Selective Sequestering of Heavy Metals (2006)
C. A. Bell, S. V. Smith, M. R. Whittaker, A. K. Whittaker, L. R. Gahan, M. J. Monteiro
This is the highest impact factor journal (8.078) for Material Science. The work involves the synthesis of polymer nanoparticles with functional surfaces and polymer chemical composition for...
The Catalytic Mechanisms of Binuclear Metallohydrolases (2006)
Mitic, N., Smith, S. J., Neves, A., Guddat, L. W., Gahan, L. R., Schenk, G.
Surface-functionalized polymer nanoparticles for selective sequestering of heavy metals (2006)
Bell, C. A., Smith, S. V., Whittaker, M. R., Whittaker, A. K., Gahan, L. R., Monteiro, M. J.
Xanthate-mediated (reversible addition-fragmentation chain transfer) emulsion polymerization has been used to create novel polystyrene nanoparticles with functionalized surfaces (see Figure) for the...
GA(III) as an analogue of FE(III) in purple acid phosphatases and related model compounds (2006)
Smith, S J, Casselato, A., Mitic, N, Riley, M J, Neves, A., Schenk, G, ...
The Catalytic Mechanisms of Binuclear Metallohydrolases (2006)
Mitic, N., Smith, S. J., Neves, A., Guddat, L. W., Gahan, L. R., Schenk, G.
Surface-functionalized polymer nanoparticles for selective sequestering of heavy metals (2006)
Bell, C. A., Smith, S. V., Whittaker, M. R., Whittaker, A. K., Gahan, L. R., Monteiro, M. J.
Xanthate-mediated (reversible addition-fragmentation chain transfer) emulsion polymerization has been used to create novel polystyrene nanoparticles with functionalized surfaces (see Figure) for the...
Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism (2006)
Elliott, T. W., Mitic, N., Gahan, L. R., Guddat, L. W., Schenk, G.
Purple acid phosphatases (PAPs) belong to the family of binuclear metallohydrolases and catalyse the hydrolysis of a large group of phosphoester substrates at acidic pH. Despite structural...
Biomimetics and a derivative of pig purple acid phosphatase with FeIIINiII binuclear centres (2006)
Herrald, P. R., Drew, S. C., Neves, A., Murray, R., Moubaraki, B., Mitic, N, ...
GA(III) as an analogue of FE(III) in purple acid phosphatases and related model compounds (2006)
Smith, S J, Casselato, A., Mitic, N, Riley, M J, Neves, A., Schenk, G, ...
Schenk, G., Gahan, L. R., Carrington, L. E., Mitic, N., Valizadeh, M., Hamilton, S. E., ...
Purple acid phosphatases (PAPs) are a family of binuclear metalloenzymes that catalyze the hydrolysis of phosphoric acid esters and anhydrides. A PAP in sweet potato has a unique, strongly...
Lanznaster, M., Neves, A., Bortoluzzi, A. J., Aires, VV. E., Szpoganicz, B., Terenzi, H., ...
A novel heterobinuclear mixed valence complex [Fe-III Cu-II(BPBPMP)(OAc)(2)] ClO4, 1, with the unsymmetrical N5O2 donor ligand 2-bis[{(2-pyridylmethyl)...
Ali, M. A., Mirza, A. H., Fereday, R. J., Butcher, R. J., Fuller, J. M., Drew, S. C., ...
New copper(II) complexes of general empirical formula, Cu(mpsme)X center dot xCH(3)COCH(3) (mpsme = anionic form of the 6-methyl-2-formylpyridine Schiff base of S-methyldithiocarbazate; X = Cl, N-3,...
Schenk, G., Gahan, L. R., Carrington, L. E., Mitic, N., Valizadeh, M., Hamilton, S. E., ...
Purple acid phosphatases (PAPs) are a family of binuclear metalloenzymes that catalyze the hydrolysis of phosphoric acid esters and anhydrides. A PAP in sweet potato has a unique, strongly...
Ali, M. A., Mirza, A. H., Fereday, R. J., Butcher, R. J., Fuller, J. M., Drew, S. C., ...
New copper(II) complexes of general empirical formula, Cu(mpsme)X center dot xCH(3)COCH(3) (mpsme = anionic form of the 6-methyl-2-formylpyridine Schiff base of S-methyldithiocarbazate; X = Cl, N-3,...
Van Den Brenk, A. L, Tyndall, J. D. A, Cusack, R. M, Jones, A, Fairlie, D. P, Gahan, L. R, ...
This is one of a series of ten papers reporting aspects of the chemistry of cyclic peptides of marine origin. All reported significant results regarding the binding of metal ions. Here the binding of...
Van Den Brenk, A. L, Tyndall, J. D. A, Cusack, R. M, Jones, A, Fairlie, D. P, Gahan, L. R, ...
This is one of a series of ten papers reporting aspects of the chemistry of cyclic peptides of marine origin. All reported significant results regarding the binding of metal ions. Here the binding of...
Sharrad, C. A., Cavigliasso, G. E., Stranger, R., Gahan, L. R.
The syntheses of the hexadentate ligands 2,2,10,10-tetra(methyleneamine)-4,8-dithiaundecane (PrN(4)S(2)amp), 2,2,11,11-tetra(methyleneamine)-4,9-dithiadodecane (BuN(4)S(2)amp), and...
Synthesis and characterization of cobalt(III) complexes with sinambic amplector ligands (2004)
The synthesis of the hexadentate ligand 5,6-dimethyl-2,2,9,9-tetra(methyleneamine)-4,7-dithiadecane (1,2-Me(2)EtN(4)S(2)amp) is reported. The diastereiosomers were separated as cobalt(III) complexes...
Sharrad, C. A., Cavigliasso, G. E., Stranger, R., Gahan, L. R.
The syntheses of the hexadentate ligands 2,2,10,10-tetra(methyleneamine)-4,8-dithiaundecane (PrN(4)S(2)amp), 2,2,11,11-tetra(methyleneamine)-4,9-dithiadodecane (BuN(4)S(2)amp), and...
Synthesis and characterization of cobalt(III) complexes with sinambic amplector ligands (2004)
The synthesis of the hexadentate ligand 5,6-dimethyl-2,2,9,9-tetra(methyleneamine)-4,7-dithiadecane (1,2-Me(2)EtN(4)S(2)amp) is reported. The diastereiosomers were separated as cobalt(III) complexes...
Piezoelectric Metal Biosensors (2003)
Raymond, K. N., Hawkins, C. J., Gahan, L. R.
We have investigated the response of 10 MHz AT-cut Ag electroded piezoelectric crystals to aqueous NaCl solutions (concentration 0.5 to 1.0 mM) and found that the frequency change is linear in this...
Cusack, R., Grondahl, L., Fairlie, D., Hanson, G. R., Gahan, L. R.
Metal ion binding properties of the immunosuppressant drug cyclosporin A have been investigated. Complexation studies in acetonitrile solution using H-1 NMR and CD spectroscopy yielded 1:1...
Ali, M. A., Mirza, A. H., Nazimuddin, M., Ahmed, R., Gahan, L. R., Bernhardt, P. V.
New mono- and bis-chelated zinc(II) and cadmium(II) complexes of formula, [M(dpksbz)NCS] (dpksbz = anionic form of the di-2-pyridylketone Schiff base of S-benzyldithiocarbazate) and [M(dpksbz)(2)] (M...
Ali, M. A., Mirza, A. H., Nazimuddin, M., Ahmed, R., Gahan, L. R., Bernhardt, P. V.
New mono- and bis-chelated zinc(II) and cadmium(II) complexes of formula, [M(dpksbz)NCS] (dpksbz = anionic form of the di-2-pyridylketone Schiff base of S-benzyldithiocarbazate) and [M(dpksbz)(2)] (M...
Cusack, R., Grondahl, L., Fairlie, D., Hanson, G. R., Gahan, L. R.
Metal ion binding properties of the immunosuppressant drug cyclosporin A have been investigated. Complexation studies in acetonitrile solution using H-1 NMR and CD spectroscopy yielded 1:1...
Cusack, R. M., Grondahl, L., Fairlie, D. P., Gahan, L. R., Hanson, G. R.
Solution conformation and calcium binding properties have been investigated for the two cyclic octapeptides cyclo(-D-Thr-D-Val(Thz)-Ile-)(2) (4) and cyclo(-Thr-Gly(Thz)-Ile-Ser-Gly(Thz)-Ile-)(5) and...
Bernhardt, P. V., Comba, P., Fairlie, D. P., Gahan, L. R., Hanson, G. R., Lotzbeyer, L.
The synthesis, characterization and copper(II) coordination chemistry of three new cyclic peptide ligands, PatJ(1) (cyclo-(Ile -Thr- (Gly)Thz-lle-Thr(Gly)Thz)), PatJ(2)...
Characterization of [Fe(AMN3S3sarH)]3+ - a rigorously low-spin iron(II) complex (2002)
The iron(II) complex [Fe(AMN(3)S(3)sarH)](ClO4)(3).3H(2)O (AMN(3)S(3)sarH = 8-ammonio-1-methyl-3,13,16-trithia-6,10,19-triazabicyclo[6.6.6]icosane) has been synthesized and characterized by single...
Cusack, R. M., Grondahl, L., Fairlie, D. P., Gahan, L. R., Hanson, G. R.
Solution conformation and calcium binding properties have been investigated for the two cyclic octapeptides cyclo(-D-Thr-D-Val(Thz)-Ile-)(2) (4) and cyclo(-Thr-Gly(Thz)-Ile-Ser-Gly(Thz)-Ile-)(5) and...
Bernhardt, P. V., Comba, P., Fairlie, D. P., Gahan, L. R., Hanson, G. R., Lotzbeyer, L.
The synthesis, characterization and copper(II) coordination chemistry of three new cyclic peptide ligands, PatJ(1) (cyclo-(Ile -Thr- (Gly)Thz-lle-Thr(Gly)Thz)), PatJ(2)...
Characterization of [Fe(AMN3S3sarH)]3+ - a rigorously low-spin iron(II) complex (2002)
The iron(II) complex [Fe(AMN(3)S(3)sarH)](ClO4)(3).3H(2)O (AMN(3)S(3)sarH = 8-ammonio-1-methyl-3,13,16-trithia-6,10,19-triazabicyclo[6.6.6]icosane) has been synthesized and characterized by single...
Sharrad, C. A., Grondahl, L., Gahan, L. R.
The reactions of mercury(II) with the mixed donor encapsulating ligands 3,6,16-trithia-6,11,19-triazabicyclo[6.6.6]icosane (AMN(3)S(3)sar) and...
A quartz crystal microbalance modified by the attachment of silica particles derivatized with the aminopolycarboxylate ligand N-[(3-trimethoxysilyl)propyl]ethylenediamine-N,N',N'-triacetic acid has...
Singh, Y., Sokolenko, N., Kelso, M. J., Gahan, L. R., Abbenante, G., Fairlie, D. P.
This is one of a series of ten papers reporting aspects of the chemistry of cyclic peptides of marine origin. All reported significant results regarding the binding of metal ions. Here the structural...
Sharrad, C. A., Grondahl, L., Gahan, L. R.
The reactions of mercury(II) with the mixed donor encapsulating ligands 3,6,16-trithia-6,11,19-triazabicyclo[6.6.6]icosane (AMN(3)S(3)sar) and...
A quartz crystal microbalance modified by the attachment of silica particles derivatized with the aminopolycarboxylate ligand N-[(3-trimethoxysilyl)propyl]ethylenediamine-N,N',N'-triacetic acid has...
Singh, Y., Sokolenko, N., Kelso, M. J., Gahan, L. R., Abbenante, G., Fairlie, D. P.
This is one of a series of ten papers reporting aspects of the chemistry of cyclic peptides of marine origin. All reported significant results regarding the binding of metal ions. Here the structural...
Cusack, R. M., Grondahl, L., Abbenante, G., Fairlie, D. P., Gahan, L. R., Hanson, G. R., ...
A comparison is made between the structures and calcium binding properties of four cyclic octapeptides that differ in the number of heterocyclic thiazole and oxazoline ring constraints. The...
Cusack, R. M., Grondahl, L., Abbenante, G., Fairlie, D. P., Gahan, L. R., Hanson, G. R., ...
A comparison is made between the structures and calcium binding properties of four cyclic octapeptides that differ in the number of heterocyclic thiazole and oxazoline ring constraints. The...
Grondahl, L., Sokolenko, N., Abbenante, G., Fairlie, D. P., Hanson, G. R., Gahan, L. R.
The interactions between zinc salts and the naturally occurring cyclic octapeptide ascidiacyclamide in methanol, as well as a synthetic analogue cyclo[Ile(Oxn)-D-Val(Thz)](2), were monitored by H-1...
Marcus, S., Bernhardt, P. V., Grondahl, L., Gahan, L. R.
The 12-membered macrocyclic ligand 1-thia-4,7, 10-triazacyclododecane ([12]aneN(3)S) has been synthesised, although upon crystallization from acetonitrile a product in which carbon dioxide had added...
Diammineplatinum(II) metabolites studied using HPLC coupled with NMR (1999)
El-Khateeb, M., Bolton, A. J., Appleton, T. G., Charles, B. G., Gahan, L. R.
Cyclic peptides as metal ion receptors (1999)
Cusack, R., Grondahl, L., Abbenante, J., Fairlie, D., Gahan, L. R., Hambley, T. W., ...
Mercury(II) and lead (II) complexes of 1-Oxa-7-thia-4,10-diazacyclododecane ([12]aneN2OS) (1999)
Afshar, S., Marcus, S., Gahan, L. R., Hambley, T. W.
The mixed donor 12-membered macrocyclic ligand 1-oxa-7-thia-4,10-diazacyclododecane ([12]aneN2OS) has been synthesized and the mercury(II) and lead(II) complexes, [Hg([12]aneN2OS)(NO3)2] and...
Masters, V., Bernhardt, P. V., Gahan, L. R., Moubaraki, B., Murray, K. S., Berry, K. J.
Reaction of K3[Cr(ox)3] (ox = oxalate) with nickel(II) and tris(2-aminoethyl)amine (tren) in aqueous solution resulted in isolation of the bimetallic assembly [Ni3(tren)4(H2O)2][Cr(ox)3]2ยท6H2O. The...
Detection of lead(II) and silver(I) in aqueous solution using a piezoelectric device (1999)
Cox, M., Hill, L. M., Gahan, L. R.
The gold surface of a quartz crystal microbalance was modified by the attachment of silica particles derivatised with N-[(3-trimethoxysilyl)propyl] ethylenediaminetriacetic acid. The device was...
Grondahl, L., Sokolenko, N., Abbenante, G., Fairlie, D. P., Hanson, G. R., Gahan, L. R.
The interactions between zinc salts and the naturally occurring cyclic octapeptide ascidiacyclamide in methanol, as well as a synthetic analogue cyclo[Ile(Oxn)-D-Val(Thz)](2), were monitored by H-1...
Detection of lead(II) and silver(I) in aqueous solution using a piezoelectric device (1999)
Cox, M., Hill, L. M., Gahan, L. R.
The gold surface of a quartz crystal microbalance was modified by the attachment of silica particles derivatised with N-[(3-trimethoxysilyl)propyl] ethylenediaminetriacetic acid. The device was...
Masters, V. M., Bernhardt, P. V., Gahan, L. R., Moubaraki, B., Murray, K. S., Berry, K. J.
Reaction of K-3[Cr(ox)(3)] (ox = oxalate) with nickel(II) and tris(2-aminoethyl)amine (tren) in aqueous solution resulted in isolation of the bimetallic assembly...
Marcus, S., Bernhardt, P. V., Grondahl, L., Gahan, L. R.
The 12-membered macrocyclic ligand 1-thia-4,7, 10-triazacyclododecane ([12]aneN(3)S) has been synthesised, although upon crystallization from acetonitrile a product in which carbon dioxide had added...
Diammineplatinum(II) metabolites studied using HPLC coupled with NMR (1999)
El-Khateeb, M., Bolton, A. J., Appleton, T. G., Charles, B. G., Gahan, L. R.
Cyclic peptides as metal ion receptors (1999)
Cusack, R., Grondahl, L., Abbenante, J., Fairlie, D., Gahan, L. R., Hambley, T. W., ...
Mercury(II) and lead (II) complexes of 1-Oxa-7-thia-4,10-diazacyclododecane ([12]aneN2OS) (1999)
Afshar, S., Marcus, S., Gahan, L. R., Hambley, T. W.
The mixed donor 12-membered macrocyclic ligand 1-oxa-7-thia-4,10-diazacyclododecane ([12]aneN2OS) has been synthesized and the mercury(II) and lead(II) complexes, [Hg([12]aneN2OS)(NO3)2] and...
Stranger, R., McMahon, K. L., Gahan, L. R., Bruce, J. I., Hambley, T. W.
A study of spin-orbit mixing and nephelauxetic effects in the electronic spectra of nickel(II)-encapsulating complexes involving mixed nitrogen and sulfur donors is reported. As the number of sulfur...
Stranger, R., McMahon, K. L., Gahan, L. R., Bruce, J. I., Hambley, T. W.
A study of spin-orbit mixing and nephelauxetic effects in the electronic spectra of nickel(II)-encapsulating complexes involving mixed nitrogen and sulfur donors is reported. As the number of sulfur...