L. Samson

Publication List Details

Period

1995 - 2007

Number

62

Co-Authors

Understanding and measuring AIDS-related settings: A developing country perspective (2007)

Mahendra, V S, Gilborn, L, Bharat, S, Mudoi, R, Gupta, I, George, B, ...

AIDS-related stigma and discrimination remain pervasive problems in health care institutions worldwide. This paper reports on stigma-related baseline findings from a study in New Delhi, India to...

Gravity Driven Motion Of A Single Sphere On A Rough Inclined Surface (1997)

D. Bideau, L. Samson, G. G. Batrouni, A. Aguirre, A. Calvo, C. Henrique

this paper is to present a general overview of the results, with special attention to our recent results from noise measurements, which help characterize the motion at the microscopic scale, and also...

Motion of a Ball on a Rough Inclined Plane (1997)

L. Samson, G. G. Batrouni

Introduction To understand the basics of segregation by flow, several experiments have been done on the motion of balls down a rough inclined plane. These experiments have yielded several surprising...

Diffusive Motion of Single Particles on an Inclined Bumpy Plane (1997)

L. Samson, G. G. Batrouni

: We study, experimentally and numerically, the properties of the motion of single particles on an inclined bumpy plane. We are mostly interested here in the range of angles of inclination, `, where...

Diffusive motion of single particles on an inclined bumpy plane L. Samson, I. Ippolito (1997)

L. Samson, G. G. Batrouni

: We study, experimentally and numerically, the properties of the motion of single particles on an inclined bumpy plane. We are mostly interested here in the range of angles of inclination, `, where...

Gravity Driven Motion Of A Single Sphere On A Rough Inclined Surface (1997)

D. Bideau, L. Samson, G. G. Batrouni, A. Aguirre, A. Calvo, C. Henrique

this paper is to present a general overview of the results, with special attention to our recent results from noise measurements, which help characterize the motion at the microscopic scale, and also...

Diffusive motion of single particles on an inclined bumpy plane L. Samson, I. Ippolito (1997)

L. Samson, G. G. Batrouni

We study, experimentally and numerically, the properties of the motion of single particles on an inclined bumpy plane. We are mostly interested here in the range of angles of inclination, `, where...

Gravity Driven Motion Of A Single Sphere On A Rough Inclined Surface (1997)

D. Bideau, L. Samson, G. G. Batrouni, A. Aguirre, A. Calvo, C. Henrique

this paper is to present a general overview of the results, with special attention to our recent results from noise measurements, which help characterize the motion at the microscopic scale, and also...

Stochastic Model for the Motion of a Particle on an Inclined Rough Plane and the Onset of Viscous Friction (1997)

G. G. Batrouni, L. Samson

Experiments on the motion of a particle on an inclined rough plane have yielded some surprising results. For example, it was found that the frictional force acting on the ball is viscous, i.e....

Motion of a Ball on a Rough Inclined Plane (1997)

L. Samson, G. G. Batrouni

Introduction To understand the basics of segregation by flow, several experiments have been done on the motion of balls down a rough inclined plane. These experiments have yielded several surprising...

Stochastic Model for the Motion of a Particle on an Inclined Rough Plane and the Onset of Viscous Friction (1995)

Batrouni, G. G., Dippel, S., Samson, L.

Experiments on the motion of a particle on an inclined rough plane have yielded some surprising results. For example, it was found that the frictional force acting on the ball is viscous, {\it i.e.}...

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent.

Maze, R, Carney, J P, Kelley, M R, Glassner, B J, Williams, D A, Samson, L

The chloroethylnitrosourea (CNU) alkylating agents are commonly used for cancer chemotherapy, but their usefulness is limited by severe bone marrow toxicity that causes the cumulative depletion of...

Replication protein A binds to regulatory elements in yeast DNA repair and DNA metabolism genes.

Singh, K K, Samson, L

Saccharomyces cerevisiae responds to DNA damage by arresting cell cycle progression (thereby preventing the replication and segregation of damaged chromosomes) and by inducing the expression of...

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

Xiao, W, Samson, L

Three genes that participate in the repair of DNA alkylation damage were recently cloned from Saccharomyces cerevisiae: the MGT1 O6-methylguanine DNA methyltransferase gene, the MAG 3-methyladenine...

Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.

Matijasevic, Z, Boosalis, M, Mackay, W, Samson, L, Ludlum, D B

A eukaryotic 3-methyladenine DNA glycosylase gene, the Saccharomyces cerevisiae MAG gene, was shown to prevent N-(2-chloroethyl)-N-nitrosourea toxicity. Disruption of the MAG gene by insertion of the...

Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16.

Samson, L, Derfler, B, Boosalis, M, Call, K

We described previously the isolation of a Saccharomyces cerevisiae 3-methyladenine (3-MeAde) DNA glycosylase repair gene (MAG) by its expression in glycosylase-deficient Escherichia coli alkA tag...

Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes.

Wei, Y F, Chen, B J, Samson, L

The alkB gene is one of a group of alkylation-inducible genes in Escherichia coli, and its product protects cells from SN2-type alkylating agents such as methyl methanesulfonate (MMS). However, the...

The Escherichia coli AlkB protein protects human cells against alkylation-induced toxicity.

Chen, B J, Carroll, P, Samson, L

Escherichia coli can ameliorate the toxic effects of alkylating agents either by preventing DNA alkylation or by repairing DNA alkylation damage. The alkylation-sensitive phenotype of E. coli alkB...

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase.

Rebeck, G W, Samson, L

Escherichia coli expresses two DNA repair methyltransferases (MTases) that repair the mutagenic O6-methylguanine (O6MeG) and O4-methylthymine (O4MeT) DNA lesions; one is the product of the inducible...

Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium.

Rebeck, G W, Smith, C M, Goad, D L, Samson, L

Escherichia coli has two DNA repair methyltransferases (MTases): the 39-kilodalton (kDa) Ada protein, which can undergo proteolysis to an active 19-kDa fragment, and the 19-kDa DNA MTase II. We...

Pathways of mutagenesis and repair in Escherichia coli exposed to low levels of simple alkylating agents.

Schendel, P F, Defais, M, Jeggo, P, Samson, L, Cairns, J

Mutagenesis by simple alkylating agents is thought to occur by either a lexA+-dependent process called error-prone repair or a lex-independent process often attributed to mispairing during...

A second DNA methyltransferase repair enzyme in Escherichia coli.

Rebeck, G W, Coons, S, Carroll, P, Samson, L

The Escherichia coli ada-alkB operon encodes a 39-kDa protein (Ada) that is a DNA-repair methyltransferase and a 27-kDa protein (AlkB) of unknown function. By DNA blot hybridization analysis we show...

Cloning a eukaryotic DNA glycosylase repair gene by the suppression of a DNA repair defect in Escherichia coli.

Chen, J, Derfler, B, Maskati, A, Samson, L

If eukaryotic genes could protect bacteria with defects in DNA repair, this effect could be exploited for the isolation of eukaryotic DNA repair genes. We have thus cloned a DNA repair gene from...

Induction of S.cerevisiae MAG 3-methyladenine DNA glycosylase transcript levels in response to DNA damage.

Chen, J, Samson, L

We previously showed that the expression of the Saccharomyces cerevisiae MAG 3-methyladenine (3MeA) DNA glycosylase gene, like that of the E. coli alkA 3MeA DNA glycosylase gene, is induced by...

The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions.

Xiao, W, Samson, L

We previously cloned a yeast DNA fragment that, when fused with the bacterial lacZ promoter, produced O6-methylguanine DNA repair methyltransferase (MGT1) activity and alkylation resistance in...

A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae.

Xiao, W, Singh, K K, Chen, B, Samson, L

The Saccharomyces cerevisiae MAG gene encodes a 3-methyladenine DNA glycosylase that protects cells from killing by alkylating agents. MAG mRNA levels are induced not only by alkylating agents but...

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.

Samson, L, Derfler, B, Waldstein, E A

The ada-alkB operon protects Escherichia coli against the effects of many alkylating agents. We have subcloned it into the pSV2 mammalian expression vector to yield pSV2ada-alkB, and this plasmid has...

Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.

Engelward, B P, Dreslin, A, Christensen, J, Huszar, D, Kurahara, C, Samson, L

In Escherichia coli, the repair of 3-methyladenine (3MeA) DNA lesions prevents alkylation-induced cell death because unrepaired 3MeA blocks DNA replication. Whether this lesion is cytotoxic to...

Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene.

Xiao, W, Derfler, B, Chen, J, Samson, L

We previously identified and characterized biochemically an O6-methylguanine (O6MeG) DNA repair methyltransferase (MTase) in the yeast Saccharomyces cerevisiae and showed that it recognizes both...

Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.

Samson, L, Thomale, J, Rajewsky, M F

The in vivo removal of three different O-alkylated bases from DNA was measured in Escherichia coli. Using monoclonal antibodies specific for O6-methylguanine, O6-ethylguanine and O4-ethylthymine we...

All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.

Dosanjh, M K, Chenna, A, Kim, E, Fraenkel-Conrat, H, Samson, L, Singer, B

We have previously reported that human cells and tissues contain a 1,N6-ethenoadenine (epsilon A) binding protein, which, through glycosylase activity, releases both 3-methyladenine (m3A) and epsilon...

Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage.

Chen, J, Derfler, B, Samson, L

We previously cloned a DNA fragment from Saccharomyces cerevisiae that suppressed the alkylation sensitivity of Escherichia coli glycosylase deficient mutants and we showed that it apparently...

Evidence-based guidelines for universal counselling and offering of HIV testing in pregnancy in Canada

Samson, L, King, S

OBJECTIVE: To provide Canadian health care workers with evidence-based guidelines for universal counselling about HIV testing and the offering of such testing to all pregnant women. OPTIONS:...

Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent.

Maze, R, Carney, J P, Kelley, M R, Glassner, B J, Williams, D A, Samson, L

The chloroethylnitrosourea (CNU) alkylating agents are commonly used for cancer chemotherapy, but their usefulness is limited by severe bone marrow toxicity that causes the cumulative depletion of...

Replication protein A binds to regulatory elements in yeast DNA repair and DNA metabolism genes.

Singh, K K, Samson, L

Saccharomyces cerevisiae responds to DNA damage by arresting cell cycle progression (thereby preventing the replication and segregation of damaged chromosomes) and by inducing the expression of...

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

Xiao, W, Samson, L

Three genes that participate in the repair of DNA alkylation damage were recently cloned from Saccharomyces cerevisiae: the MGT1 O6-methylguanine DNA methyltransferase gene, the MAG 3-methyladenine...

Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.

Matijasevic, Z, Boosalis, M, Mackay, W, Samson, L, Ludlum, D B

A eukaryotic 3-methyladenine DNA glycosylase gene, the Saccharomyces cerevisiae MAG gene, was shown to prevent N-(2-chloroethyl)-N-nitrosourea toxicity. Disruption of the MAG gene by insertion of the...

Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16.

Samson, L, Derfler, B, Boosalis, M, Call, K

We described previously the isolation of a Saccharomyces cerevisiae 3-methyladenine (3-MeAde) DNA glycosylase repair gene (MAG) by its expression in glycosylase-deficient Escherichia coli alkA tag...

Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes.

Wei, Y F, Chen, B J, Samson, L

The alkB gene is one of a group of alkylation-inducible genes in Escherichia coli, and its product protects cells from SN2-type alkylating agents such as methyl methanesulfonate (MMS). However, the...

The Escherichia coli AlkB protein protects human cells against alkylation-induced toxicity.

Chen, B J, Carroll, P, Samson, L

Escherichia coli can ameliorate the toxic effects of alkylating agents either by preventing DNA alkylation or by repairing DNA alkylation damage. The alkylation-sensitive phenotype of E. coli alkB...

Increased spontaneous mutation and alkylation sensitivity of Escherichia coli strains lacking the ogt O6-methylguanine DNA repair methyltransferase.

Rebeck, G W, Samson, L

Escherichia coli expresses two DNA repair methyltransferases (MTases) that repair the mutagenic O6-methylguanine (O6MeG) and O4-methylthymine (O4MeT) DNA lesions; one is the product of the inducible...

Characterization of the major DNA repair methyltransferase activity in unadapted Escherichia coli and identification of a similar activity in Salmonella typhimurium.

Rebeck, G W, Smith, C M, Goad, D L, Samson, L

Escherichia coli has two DNA repair methyltransferases (MTases): the 39-kilodalton (kDa) Ada protein, which can undergo proteolysis to an active 19-kDa fragment, and the 19-kDa DNA MTase II. We...

Pathways of mutagenesis and repair in Escherichia coli exposed to low levels of simple alkylating agents.

Schendel, P F, Defais, M, Jeggo, P, Samson, L, Cairns, J

Mutagenesis by simple alkylating agents is thought to occur by either a lexA+-dependent process called error-prone repair or a lex-independent process often attributed to mispairing during...

A second DNA methyltransferase repair enzyme in Escherichia coli.

Rebeck, G W, Coons, S, Carroll, P, Samson, L

The Escherichia coli ada-alkB operon encodes a 39-kDa protein (Ada) that is a DNA-repair methyltransferase and a 27-kDa protein (AlkB) of unknown function. By DNA blot hybridization analysis we show...

Cloning a eukaryotic DNA glycosylase repair gene by the suppression of a DNA repair defect in Escherichia coli.

Chen, J, Derfler, B, Maskati, A, Samson, L

If eukaryotic genes could protect bacteria with defects in DNA repair, this effect could be exploited for the isolation of eukaryotic DNA repair genes. We have thus cloned a DNA repair gene from...

Induction of S.cerevisiae MAG 3-methyladenine DNA glycosylase transcript levels in response to DNA damage.

Chen, J, Samson, L

We previously showed that the expression of the Saccharomyces cerevisiae MAG 3-methyladenine (3MeA) DNA glycosylase gene, like that of the E. coli alkA 3MeA DNA glycosylase gene, is induced by...

The Saccharomyces cerevisiae MGT1 DNA repair methyltransferase gene: its promoter and entire coding sequence, regulation and in vivo biological functions.

Xiao, W, Samson, L

We previously cloned a yeast DNA fragment that, when fused with the bacterial lacZ promoter, produced O6-methylguanine DNA repair methyltransferase (MGT1) activity and alkylation resistance in...

A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae.

Xiao, W, Singh, K K, Chen, B, Samson, L

The Saccharomyces cerevisiae MAG gene encodes a 3-methyladenine DNA glycosylase that protects cells from killing by alkylating agents. MAG mRNA levels are induced not only by alkylating agents but...

Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes.

Samson, L, Derfler, B, Waldstein, E A

The ada-alkB operon protects Escherichia coli against the effects of many alkylating agents. We have subcloned it into the pSV2 mammalian expression vector to yield pSV2ada-alkB, and this plasmid has...

Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.

Engelward, B P, Dreslin, A, Christensen, J, Huszar, D, Kurahara, C, Samson, L

In Escherichia coli, the repair of 3-methyladenine (3MeA) DNA lesions prevents alkylation-induced cell death because unrepaired 3MeA blocks DNA replication. Whether this lesion is cytotoxic to...

Primary sequence and biological functions of a Saccharomyces cerevisiae O6-methylguanine/O4-methylthymine DNA repair methyltransferase gene.

Xiao, W, Derfler, B, Chen, J, Samson, L

We previously identified and characterized biochemically an O6-methylguanine (O6MeG) DNA repair methyltransferase (MTase) in the yeast Saccharomyces cerevisiae and showed that it recognizes both...

Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.

Samson, L, Thomale, J, Rajewsky, M F

The in vivo removal of three different O-alkylated bases from DNA was measured in Escherichia coli. Using monoclonal antibodies specific for O6-methylguanine, O6-ethylguanine and O4-ethylthymine we...

All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.

Dosanjh, M K, Chenna, A, Kim, E, Fraenkel-Conrat, H, Samson, L, Singer, B

We have previously reported that human cells and tissues contain a 1,N6-ethenoadenine (epsilon A) binding protein, which, through glycosylase activity, releases both 3-methyladenine (m3A) and epsilon...

Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage.

Chen, J, Derfler, B, Samson, L

We previously cloned a DNA fragment from Saccharomyces cerevisiae that suppressed the alkylation sensitivity of Escherichia coli glycosylase deficient mutants and we showed that it apparently...

Evidence-based guidelines for universal counselling and offering of HIV testing in pregnancy in Canada

Samson, L, King, S

OBJECTIVE: To provide Canadian health care workers with evidence-based guidelines for universal counselling about HIV testing and the offering of such testing to all pregnant women. OPTIONS:...

INTERTEMPORAL SUBSTITUTION AND DURABLE GOODS: AN EMPIRCAL ANALYSIS.

FAUVEL, Y., SAMSON, L.

substitution ; goods ; economic analysis ; macroeconomics

FLUCTUATIONS IN EMPLOYMENT GROWTH: NATIONAL OR SECTOR- SPECIFFIC DISTURBANCES

SAMSON, L.

employment ; monetary policy ; econometrics ; evaluation

Expected returns and economic risk in Canadian financial markets

B. Carmichael, L. Samson

This article estimates a linear factor model that links asset return fluctuations to: time-varying expected returns, to economic factors innovations and to a residual idiosyncratic risk. It considers...