LA Simms

Distinction between familial and sporadic forms of colorectal cancer showing DNA microsatellite instability (2002)

Jass, JR, Walsh, MD, Barker, M, Simms, LA, Young, J, Leggett, BA

Attempts to classify colorectal cancer into subtypes based upon molecular characterisation are overshadowed by the classical stepwise model in which the adenoma-carcinoma sequence serves as the...

Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer (2002)

Whitehall, VLJ, Wynter, CVA, Walsh, MD, Simms, LA, Purdie, D, Pandeya, N, ...

Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of multiple molecular...

Proliferation, apoptosis, and survival in high-level microsatellite instability sporadic colorectal cancer (2001)

Michael-Robinson, JM, Reid, LE, Purdie, DM, Biemer-Huttmann, AE, Walsh, MD, Pandeya, N, ...

Sporadic colorectal cancer (CRC) characterized by high-level DNA microsatellite instability (MSI-H) has a favorable prognosis. The reason for this MSI-H survival advantage is not known. The aim of...

Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status (2001)

Michael-Robinson, JM, Biemer-Huttmann, AE, Purdie, DM, Walsh, MD, Simms, LA, Biden, KG, ...

Background-The presence of high level DNA microsatellite instability (MSI-H) in colorectal cancer is associated with an improved prognosis, as is the presence of tumour infiltrating lymphocytes...