Lee, Wah, Wong, Christopher W, Leong, Wan, Miller, Lance D, Sung, Wing
Abstract Background Pathogen detection using DNA microarrays has the potential to become a fast and comprehensive diagnostics tool. However, since pathogen detection chips currently utilize random...
Whole-Genome Cartography of Estrogen Receptor α Binding Sites (2007)
Chin-Yo Lin, Vinsensius B. Vega, Jane S. Thomsen, Tao Zhang, Say Li Kong, Min Xie, ...
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor α (ERα) binding sites in MCF-7 breast cancer cells. We identified 1,234 high...
Optimization and clinical validation of a pathogen detection microarray (2007)
Wong, Christopher W, Heng, Charlie, Wan Yee, Leong, Soh, Shirlena WL, Kartasasmita, Cissy B, Simoes, Eric AF, ...
Abstract DNA microarrays used as 'genomic sensors' have great potential in clinical diagnostics. Biases inherent in random PCR-amplification, cross-hybridization effects, and inadequate microarray...
Lin, Chin-Yo, Ström, Anders, Li Kong, Say, Kietz, Silke, Thomsen, Jane S, Tee, Jason BS, ...
Abstract Introduction The impact of interactions between the two estrogen receptor (ER) subtypes, ERα and ERβ, on gene expression in breast cancer biology is not clear. The goal of this study was...
Miller, Lance D, Liu, Edison T
Abstract Genome-wide expression microarray studies have revealed that the biological and clinical heterogeneity of breast cancer can be partly explained by information embedded within a complex but...
Hall, Per, Ploner, Alexander, Bjöhle, Judith, Huang, Fei, Lin, Chin-Yo, Liu, Edison T, ...
Abstract Background Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood. Methods...
Transcriptome Analysis of Zebrafish Embryogenesis Using Microarrays (2005)
Sinnakaruppan Mathavan, Alicia Mak, Lance D. Miller, Kunde R. Govindarajan, ...
Zebrafish (Danio rerio) is a well-recognized model for the study of vertebrate developmental genetics, yet at the same time little is known about the transcriptional events that underlie zebrafish...
Ploner, Alexander, Miller, Lance D, Hall, Per, Bergh, Jonas, Pawitan, Yudi
Abstract Background There are currently a number of competing techniques for low-level processing of oligonucleotide array data. The choice of technique has a profound effect on subsequent...
Discovery of estrogen receptor α target genes and response elements in breast tumor cells (2004)
Lin, Chin-Yo, Ström, Anders, Vega, Vinsensius, Li Kong, Say, Li Yeo, Ai, Thomsen, Jane S, ...
Abstract Background Estrogens and their receptors are important in human development, physiology and disease. In this study, we utilized an integrated genome-wide molecular and computational approach...
Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance (2004)
Miller, Lance D, McPhie, Peter, Suzuki, Hideyo, Kato, Yasuhito, Liu, Edison T, Cheng, Sheue-yann
Abstract Background Resistance to thyroid hormone (RTH) is caused by mutations of the thyroid hormone receptor β (TRβ) gene. To understand the transcriptional program underlying TRβ mutant-induced...
Lance D. Miller, Lisa M. Mcshane, Edison T. Liu
es. The two major platforms for microarrays are spotted arrays, where the probes are mechanically deposited onto modified glass slides by contact or ink jet printing, and in situ arrays, where oligo...
"August, 1998."
Thesis (M.S.)--East Carolina University, 1995.
Thesis (Ph. D.)--University of Arizona, 1994.
Thesis (Ph. D.)--University of Arizona, 1994.
Thesis (M.S.)--University of Alaska Fairbanks, 1990.
Miller, Lance D., Park, Kyung Soo, Guo, Qingbin M., Alkharouf, Nawal W., Malek, Renae L., Lee, Norman H., ...
To investigate the transcriptional program underlying thyroid hormone (T3)-induced cell proliferation, cDNA microarrays were used to survey the temporal expression profiles of 4,400 genes. Of 358...
Khadijah, Siti, Neo, Soek Ying, Hossain, M. S., Miller, Lance D., Mathavan, S., Kwang, Jimmy
To investigate whether specific-pathogen-free (SPF) shrimps are asymptomatic carriers of white spot syndrome virus (WSSV), we used a WSSV-specific DNA microarray to measure WSSV gene expression in...
Wong, Christopher W., Albert, Thomas J., Vega, Vinsensius B., Norton, Jason E., Cutler, David J., Richmond, Todd A., ...
Mutations in the SARS-Coronavirus (SARS-CoV) can alter its clinical presentation, and the study of its mutation patterns in human populations can facilitate contact tracing. Here, we describe the...
Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance
Miller, Lance D, McPhie, Peter, Suzuki, Hideyo, Kato, Yasuhito, Liu, Edison T, Cheng, Sheue-yann
Gene-expression analysis in cerebellum, heart and white adipose tissue from a knock-in mouse that harbors a human mutation and faithfully reproduces human resistance to thyroid hormone, uncovered...
BEARR: Batch Extraction and Analysis of cis-Regulatory Regions
Vega, Vinsensius B., Bangarusamy, Dhinoth Kumar, Miller, Lance D., Liu, Edison T., Lin, Chin-Yo
Transcription factors play important roles in regulating biological and disease processes. Microarray technology has enabled researchers to simultaneously monitor changes in the expression of...
Discovery of estrogen receptor α target genes and response elements in breast tumor cells
Lin, Chin-Yo, Ström, Anders, Vega, Vinsensius Berlian, Li Kong, Say, Li Yeo, Ai, Thomsen, Jane S, ...
Microarray analysis has identified 89 estrogen target genes. The cis-regulatory elements found upstream of those genes are not well conserved in mouse and human.
Correlation test to assess low-level processing of high-density oligonucleotide microarray data
Ploner, Alexander, Miller, Lance D, Hall, Per, Bergh, Jonas, Pawitan, Yudi
Transcriptome Analysis of Zebrafish Embryogenesis Using Microarrays
Mathavan, Sinnakaruppan, Lee, Serene G. P, Mak, Alicia, Miller, Lance D, Murthy, Karuturi Radha Krishna, Govindarajan, Kunde R, ...
Zebrafish (Danio rerio) is a well-recognized model for the study of vertebrate developmental genetics, yet at the same time little is known about the transcriptional events that underlie zebrafish...
Miller, Lance D., Smeds, Johanna, George, Joshy, Vega, Vinsensius B., Vergara, Liza, Ploner, Alexander, ...
Perturbations of the p53 pathway are associated with more aggressive and therapeutically refractory tumors. However, molecular assessment of p53 status, by using sequence analysis and...
Identification of Cell Cycle-regulated Genes in Fission YeastD⃞
Peng, Xu, Karuturi, R. Krishna Murthy, Miller, Lance D., Lin, Kui, Jia, Yonghui, Kondu, Pinar, ...
Cell cycle progression is both regulated and accompanied by periodic changes in the expression levels of a large number of genes. To investigate cell cycle-regulated transcriptional programs in the...
Miller, Lance D., Park, Kyung Soo, Guo, Qingbin M., Alkharouf, Nawal W., Malek, Renae L., Lee, Norman H., ...
To investigate the transcriptional program underlying thyroid hormone (T3)-induced cell proliferation, cDNA microarrays were used to survey the temporal expression profiles of 4,400 genes. Of 358...
Khadijah, Siti, Neo, Soek Ying, Hossain, M. S., Miller, Lance D., Mathavan, S., Kwang, Jimmy
To investigate whether specific-pathogen-free (SPF) shrimps are asymptomatic carriers of white spot syndrome virus (WSSV), we used a WSSV-specific DNA microarray to measure WSSV gene expression in...
Wong, Christopher W., Albert, Thomas J., Vega, Vinsensius B., Norton, Jason E., Cutler, David J., Richmond, Todd A., ...
Mutations in the SARS-Coronavirus (SARS-CoV) can alter its clinical presentation, and the study of its mutation patterns in human populations can facilitate contact tracing. Here, we describe the...
Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance
Miller, Lance D, McPhie, Peter, Suzuki, Hideyo, Kato, Yasuhito, Liu, Edison T, Cheng, Sheue-yann
Gene-expression analysis in cerebellum, heart and white adipose tissue from a knock-in mouse that harbors a human mutation and faithfully reproduces human resistance to thyroid hormone, uncovered...
BEARR: Batch Extraction and Analysis of cis-Regulatory Regions
Vega, Vinsensius B., Bangarusamy, Dhinoth Kumar, Miller, Lance D., Liu, Edison T., Lin, Chin-Yo
Transcription factors play important roles in regulating biological and disease processes. Microarray technology has enabled researchers to simultaneously monitor changes in the expression of...
Discovery of estrogen receptor α target genes and response elements in breast tumor cells
Lin, Chin-Yo, Ström, Anders, Vega, Vinsensius Berlian, Li Kong, Say, Li Yeo, Ai, Thomsen, Jane S, ...
Microarray analysis has identified 89 estrogen target genes. The cis-regulatory elements found upstream of those genes are not well conserved in mouse and human.
Identification of Cell Cycle-regulated Genes in Fission YeastD⃞
Peng, Xu, Karuturi, R. Krishna Murthy, Miller, Lance D., Lin, Kui, Jia, Yonghui, Kondu, Pinar, ...
Cell cycle progression is both regulated and accompanied by periodic changes in the expression levels of a large number of genes. To investigate cell cycle-regulated transcriptional programs in the...
Correlation test to assess low-level processing of high-density oligonucleotide microarray data
Ploner, Alexander, Miller, Lance D, Hall, Per, Bergh, Jonas, Pawitan, Yudi
Transcriptome Analysis of Zebrafish Embryogenesis Using Microarrays
Mathavan, Sinnakaruppan, Lee, Serene G. P, Mak, Alicia, Miller, Lance D, Murthy, Karuturi Radha Krishna, Govindarajan, Kunde R, ...
Zebrafish (Danio rerio) is a well-recognized model for the study of vertebrate developmental genetics, yet at the same time little is known about the transcriptional events that underlie zebrafish...
Miller, Lance D., Smeds, Johanna, George, Joshy, Vega, Vinsensius B., Vergara, Liza, Ploner, Alexander, ...
Perturbations of the p53 pathway are associated with more aggressive and therapeutically refractory tumors. However, molecular assessment of p53 status, by using sequence analysis and...
Expression genomics in breast cancer research: microarrays at the crossroads of biology and medicine
Miller, Lance D, Liu, Edison T
Genome-wide expression microarray studies have revealed that the biological and clinical heterogeneity of breast cancer can be partly explained by information embedded within a complex but ordered...
Whole-Genome Cartography of Estrogen Receptor α Binding Sites
Lin, Chin-Yo, Vega, Vinsensius B, Thomsen, Jane S, Zhang, Tao, Kong, Say Li, Xie, Min, ...
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor α (ERα) binding sites in MCF-7 breast cancer cells. We identified 1,234 high...
Optimization and clinical validation of a pathogen detection microarray
Wong, Christopher W, Heng, Charlie Lee Wah, Wan Yee, Leong, Soh, Shirlena WL, Kartasasmita, Cissy B, Simoes, Eric AF, ...
New design and optimization of pathogen detection microarrays is shown to allow robust and accurate detection of a range of pathogens. The customized microarray platform includes a method for...