Waterland, Robert A., Kellermayer, Richard, Rached, Marie-Therese, Tatevian, Nina, Gomes, Marcus V., Zhang, Jiexin, ...
The question of whether DNA methylation contributes to the stabilization of gene expression patterns in differentiated mammalian tissues remains controversial. Using genome-wide methylation...
An Sp1/Sp3 binding polymorphism confers methylation protection. (2008)
Boumber, Yanis A, Kondo, Yutaka, Chen, Xuqi, Shen, Lanlan, Guo, Yi, Tellez, Carmen, ...
Hundreds of genes show aberrant DNA hypermethylation in cancer, yet little is known about the causes of this hypermethylation. We identified RIL as a frequent methylation target in cancer. In search...
Gao, Wentao, Kondo, Yutaka, Shen, Lanlan, Shimizu, Yasuhiro, Sano, Tsuyoshi, Yamao, Kenji, ...
Hepatocellular carcinoma (HCC) most commonly arises from chronic inflammation due to viral infection, as a result of genetic and epigenetic abnormalities. A global picture of epigenetic changes in...
High-throughput methylation profiling by MCA coupled to CpG island microarray (2007)
Estécio, Marcos R.H., Yan, Pearlly S., Ibrahim, Ashraf E.K., Tellez, Carmen S., Shen, Lanlan, Huang, Tim H.-M., ...
An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms. The lack of high-throughput methods with high specificity and sensitivity to detect changes in DNA methylation...
Lanlan Shen, Yutaka Kondo, Yi Guo, Jiexin Zhang, Li Zhang, Saira Ahmed, ...
The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter...
Lanlan Shen, Yutaka Kondo, Yi Guo, Jiexin Zhang, Li Zhang, Saira Ahmed, ...
The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter...
Correlation between CpG methylation profiles and hormone receptor status in breast cancers (2007)
Feng, Weiwei, Shen, Lanlan, Wen, Sijin, Rosen, Daniel G, Jelinek, Jaroslav, Hu, Xin, ...
Abstract Introduction Aberrant DNA methylation has been found frequently in human breast cancers, associated with the loss of expression of a number of regulatory genes for growth and correlated to...
MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer (2005)
Shen, Lanlan, Kondo, Yutaka, Rosner, Gary L., Xiao, Lianchun, Hernandez, Natalie Supunpong, Vilaythong, Jill, ...
Background: Sporadic colorectal cancers often arise from a region of cells characterized by a “field defect” that has not been well defined molecularly. DNA methylation has been proposed as a...
HLTF gene silencing in human colon cancer. (2002)
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
DNA Methylation and Environmental Exposures in Human Hepatocellular Carcinoma (2002)
Shen, Lanlan, Ahuja, Nita, Shen, Yu, Habib, Nagy A., Toyota, Minoru, Rashid, Asif, ...
Background: Hypermethylation of a CpG-rich promoter (CpG island) blocks expression of the corresponding gene. The CpG island methylator phenotype (CIMP), defined as a variable pattern of...
HLTF gene silencing in human colon cancer
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer
Kondo, Yutaka, Shen, LanLan, Issa, Jean-Pierre J.
The mechanism of DNA hypermethylation-associated tumor suppressor gene silencing in cancer remains incompletely understood. Here, we show by chromatin immunoprecipitation that for three genes (P16,...
Kondo, Yutaka, Shen, Lanlan, Yan, Pearlly S., Huang, Tim Hui-Ming, Issa, Jean-Pierre J.
Switching from acetylation to methylation at histone H3 lysine 9 (K9) has recently been shown to contribute to euchromatin gene silencing. To identify genes silenced by K9 modifications, we probed a...
HLTF gene silencing in human colon cancer
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer
Kondo, Yutaka, Shen, LanLan, Issa, Jean-Pierre J.
The mechanism of DNA hypermethylation-associated tumor suppressor gene silencing in cancer remains incompletely understood. Here, we show by chromatin immunoprecipitation that for three genes (P16,...
Kondo, Yutaka, Shen, Lanlan, Yan, Pearlly S., Huang, Tim Hui-Ming, Issa, Jean-Pierre J.
Switching from acetylation to methylation at histone H3 lysine 9 (K9) has recently been shown to contribute to euchromatin gene silencing. To identify genes silenced by K9 modifications, we probed a...
Estécio, Marcos R.H., Gharibyan, Vazganush, Shen, Lanlan, Ibrahim, Ashraf E.K., Doshi, Ketan, He, Rong, ...
CpG Island Methylation in Colorectal Adenomas
Rashid, Asif, Shen, Lanlan, Morris, Jeffrey S., Issa, Jean-Pierre J., Hamilton, Stanley R.
Methylation of cytosines in CpG islands silences gene expression. CpG island methylator phenotype (CIMP) in colorectal cancers is characterized by abnormal methylation of multiple CpG islands...
Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters
Shen, Lanlan, Kondo, Yutaka, Guo, Yi, Zhang, Jiexin, Zhang, Li, Ahmed, Saira, ...
The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter...
Correlation between CpG methylation profiles and hormone receptor status in breast cancers
Feng, Weiwei, Shen, Lanlan, Wen, Sijin, Rosen, Daniel G, Jelinek, Jaroslav, Hu, Xin, ...
Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia
Lee, Sangkyou, Jeong, Joon, Majewski, Tadeusz, Scherer, Steven E., Kim, Mi-Sook, Tuziak, Tomasz, ...
We used human bladder cancer as a model system and the whole-organ histologic and genetic mapping strategy to identify clonal genetic hits associated with growth advantage, tracking the evolution of...
High-throughput methylation profiling by MCA coupled to CpG island microarray
Estécio, Marcos R.H., Yan, Pearlly S., Ibrahim, Ashraf E.K., Tellez, Carmen S., Shen, Lanlan, Huang, Tim H.-M., ...
An abnormal pattern of DNA methylation occurs at specific genes in almost all neoplasms. The lack of high-throughput methods with high specificity and sensitivity to detect changes in DNA methylation...
Kondo, Yutaka, Shen, Lanlan, Ahmed, Saira, Boumber, Yanis, Sekido, Yoshitaka, Haddad, Bassem R., ...
Chung, Woonbok, Kwabi-Addo, Bernard, Ittmann, Michael, Jelinek, Jaroslav, Shen, Lanlan, Yu, Yinhua, ...
DNA hypermethylation is a common epigenetic abnormality in cancer and may serve as a useful marker to clone cancer-related genes as well as a marker of clinical disease activity. To identify CpG...
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
Shen, Lanlan, Toyota, Minoru, Kondo, Yutaka, Lin, E, Zhang, Li, Guo, Yi, ...
Colon cancer has been viewed as the result of progressive accumulation of genetic and epigenetic abnormalities. However, this view does not fully reflect the molecular heterogeneity of the disease....
An Sp1/Sp3 Binding Polymorphism Confers Methylation Protection
Boumber, Yanis A., Kondo, Yutaka, Chen, Xuqi, Shen, Lanlan, Guo, Yi, Tellez, Carmen, ...
Hundreds of genes show aberrant DNA hypermethylation in cancer, yet little is known about the causes of this hypermethylation. We identified RIL as a frequent methylation target in cancer. In search...
Chung, Woonbok, Kwabi-Addo, Bernard, Ittmann, Michael, Jelinek, Jaroslav, Shen, Lanlan, Yu, Yinhua, ...
Oki, Yasuhiro, Jelinek, Jaroslav, Shen, Lanlan, Kantarjian, Hagop M., Issa, Jean-Pierre J.
Decitabine's mechanism of action in chronic myelomonocytic leukemia remains incompletely understood. We studied the dynamics of neoplastic cell clearance during decitabine treatment (100 mg/m2 per...
Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse
Kroeger, Heike, Jelinek, Jaroslav, Estécio, Marcos R. H., He, Rong, Kondo, Kimie, Chung, Woonbok, ...
DNA methylation of CpG islands around gene transcription start sites results in gene silencing and plays a role in leukemia pathophysiology. Its impact in leukemia progression is not fully...