Lao H. Saal

Human Cancer Biology Estrogen Receptor B Expression Is Associated withTamoxifen Response in ERA-Negative Breast Carcinoma (2008)

Lao H. Saal, Mervi Laakso, Cecilia Hegardt, Patrik Ede N, ...

Abstract Purpose: Endocrine therapies, such as tamoxifen, are commonly given to most patients with estrogen receptor (ERa) ^ positive breast carcinoma but are not indicated for persons with...

The CD44+/CD24-phenotype is enriched in basal-like breast tumors (2008)

Honeth, Gabriella, Bendahl, Pär-Ola, Ringnér, Markus, Saal, Lao H, Gruvberger-Saal, Sofia K, Lövgren, Kristina, ...

Abstract Introduction Human breast tumors are heterogeneous and consist of phenotypically diverse cells. Breast cancer cells with a CD44 + /CD24 - phenotype have been suggested to have...

BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data (2002)

Saal, Lao H, Troein, Carl, Vallon-Christersson, Johan, Gruvberger, Sofia, Borg, Åke, Peterson, Carsten

Abstract The microarray technique requires the organization and analysis of vast amounts of data. These data include information about the samples hybridized, the hybridization images and their...

Bioarray software environment (base): a platform for comprehensive management and analysis of microarray data (2002)

Lao H Saal, Carl Troein, Johan Vallon-christersson, Sofia Gruvberger, Åke Borg, Carsten Peterson

(Print ISSN 1465-6906; Online ISSN 1465-6914) The microarray technique requires the organization and analysis of vast amounts of data. These data include information about the samples hybridized, the...

Advances in Brief Estrogen Receptor Status in Breast Cancer Is Associated with Remarkably Distinct Gene Expression Patterns 1 (2001)

Sofia Gruvberger, Markus Ringnér, Yidong Chen, Sujatha Panavally, Lao H. Saal, Åke Borg, ...

To investigate the phenotype associated with estrogen receptor � (ER) expression in breast carcinoma, gene expression profiles of 58 nodenegative breast carcinomas discordant for ER status were...

cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene

Khan, Javed, Bittner, Michael L., Saal, Lao H., Teichmann, Ulrike, Azorsa, David O., Gooden, Gerald C., ...

Alveolar rhabdomyosarcoma is an aggressive pediatric cancer of striated muscle characterized in 60% of cases by a t(2;13)(q35;q14). This results in the fusion of PAX3, a developmental transcription...

BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data

Saal, Lao H, Troein, Carl, Vallon-Christersson, Johan, Gruvberger, Sofia, Borg, Åke, Peterson, Carsten

The microarray technique requires the organization and analysis of vast amounts of data. These data include information about the samples hybridized, the hybridization images and their extracted data...

Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

Khan, Javed, Wei, Jun S., Ringnér, Markus, Saal, Lao H., Ladanyi, Marc, Westermann, Frank, ...

The purpose of this study was to develop a method of classifying cancers to specific diagnostic categories based on their gene expression signatures using artificial neural networks (ANNs). We...

cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene

Khan, Javed, Bittner, Michael L., Saal, Lao H., Teichmann, Ulrike, Azorsa, David O., Gooden, Gerald C., ...

Alveolar rhabdomyosarcoma is an aggressive pediatric cancer of striated muscle characterized in 60% of cases by a t(2;13)(q35;q14). This results in the fusion of PAX3, a developmental transcription...

BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data

Saal, Lao H, Troein, Carl, Vallon-Christersson, Johan, Gruvberger, Sofia, Borg, Åke, Peterson, Carsten

The microarray technique requires the organization and analysis of vast amounts of data. These data include information about the samples hybridized, the hybridization images and their extracted data...

Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity

Saal, Lao H., Johansson, Peter, Holm, Karolina, Gruvberger-Saal, Sofia K., She, Qing-Bai, Maurer, Matthew, ...

Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid tumors; however, currently, no reliable test...