Larry O. Arthur

Envelope Protein on the Virion Surface (2002)

Richard D. Leapman, Jacob Lebowitz, Larry O. Arthur, Patricia L. Earl, Bernard Moss

The envelope protein (Env) of human immunodeficiency virus type 1 forms homo-oligomers in the endoplasmic reticulum. The oligomeric structure of Env is maintained after cleavage in a Golgi...

Control of Pantothenate Accumulation in Agrobacterium tumefaciens (1973)

Kaneshiro, Tsuneo, Arthur, Larry O., Nickerson, Kenneth

Two pantothenate-requiring mutants of Agrobacterium tumefaciens have been isolated. One of them (strain WMP-1) is unusual in that growth levels equivalent to the parent strain are achieved only when...

Oligomeric structure of virion-associated and soluble forms of the simian immunodeficiency virus envelope protein in the prefusion activated conformation

Center, Rob J., Schuck, Peter, Leapman, Richard D., Arthur, Larry O., Earl, Patricia L., Moss, Bernard, ...

The envelope proteins (env) of simian immunodeficiency virus (SIV) and HIV type 1 assemble to form noncovalently associated oligomers in the endoplasmic reticulum. After cleavage in a Golgi...

Ubiquitin Is Covalently Attached to the p6Gag Proteins of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus and to the p12Gag Protein of Moloney Murine Leukemia Virus

Ott, David E., Coren, Lori V., Copeland, Terry D., Kane, Bradley P., Johnson, Donald G., Sowder, Raymond C., ...

Host proteins are incorporated into retroviral virions during assembly and budding. We have examined three retroviruses, human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus...

Protection of Macaca nemestrina from Disease following Pathogenic Simian Immunodeficiency Virus (SIV) Challenge: Utilization of SIV Nucleocapsid Mutant DNA Vaccines with and without an SIV Protein Boost

Gorelick, Robert J., Benveniste, Raoul E., Lifson, Jeffrey D., Yovandich, Jason L., Morton, William R., Kuller, LaRene, ...

Molecular clones were constructed that express nucleocapsid (NC) deletion mutant simian immunodeficiency viruses (SIVs) that are replication defective but capable of completing virtually all of the...

Characterization of the Block in Replication of Nucleocapsid Protein Zinc Finger Mutants from Moloney Murine Leukemia Virus

Gorelick, Robert J., Fu, William, Gagliardi, Tracy D., Bosche, William J., Rein, Alan, Henderson, Louis E., ...

Mutagenesis studies have shown that retroviral nucleocapsid (NC) protein Zn2+ fingers (-Cys-X2-Cys-X4-His-X4-Cys- [CCHC]) perform multiple functions in the virus life cycle. Moloney murine leukemia...

Partial Activation and Induction of Apoptosis in CD4+ and CD8+ T Lymphocytes by Conformationally Authentic Noninfectious Human Immunodeficiency Virus Type 1†

Esser, Mark T., Bess, Julian W., Suryanarayana, Kalachar, Chertova, Elena, Marti, Darlene, Carrington, Mary, ...

Increased levels of apoptosis are seen in human immunodeficiency virus (HIV) infection, and this has been proposed as an important mechanism contributing to HIV pathogenesis. However, interpretation...

Identification of Highly Attenuated Mutants of Simian Immunodeficiency Virus

Desrosiers, Ronald C., Lifson, Jeffrey D., Gibbs, James S., Czajak, Susan C., Howe, Anita Y. M., Arthur, Larry O., ...

Deletion mutants of the pathogenic clone of simian immunodeficiency virus isolate 239 (SIVmac239) were derived that are missing nef, vpr, and upstream sequences (US) in the U3 region of the LTR...

Oligomeric Structure of the Human Immunodeficiency Virus Type 1 Envelope Protein on the Virion Surface

Center, Rob J., Leapman, Richard D., Lebowitz, Jacob, Arthur, Larry O., Earl, Patricia L., Moss, Bernard

The envelope protein (Env) of human immunodeficiency virus type 1 forms homo-oligomers in the endoplasmic reticulum. The oligomeric structure of Env is maintained after cleavage in a Golgi...

Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

Chertova, Elena, Crise, Bruce J., Sowder II, Raymond C., Schaden, Terra M., Hilburn, Joanne M., ...

Human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) particles typically contain small amounts of the surface envelope protein (SU), and this is widely believed to be...

Control of Viremia and Prevention of Simian-Human Immunodeficiency Virus-Induced Disease in Rhesus Macaques Immunized with Recombinant Vaccinia Viruses plus Inactivated Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Particles

Willey, Ronald L., Byrum, Russ, Piatak, Michael, Kim, Young B., Cho, Michael W., ...

An effective vaccine against the human immunodeficiency virus type 1 (HIV-1) will very likely have to elicit both cellular and humoral immune responses to control HIV-1 strains of diverse geographic...

Cholesterol Depletion of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus with β-Cyclodextrin Inactivates and Permeabilizes the Virions: Evidence for Virion-Associated Lipid Rafts

Graham, David R. M., Chertova, Elena, Hilburn, Joanne M., Arthur, Larry O., Hildreth, James E. K.

Recent evidence suggests that human immunodeficiency virus type 1 (HIV-1) particles assemble and bud selectively through areas in the plasma membrane of cells that are highly enriched with...

Carbohydrate Catabolism of Selected Strains in the Genus Agrobacterium

Arthur, Larry O., Nakamura, Lawrence K., Julian, Grant St., Bulla, Lee A.

Radiorespirometric and enzyme analyses were used to reveal the glucose-catabolizing mechanisms functioning in single strains of seven presumed Agrobacterium species. The Entner-Doudoroff and pentose...

Carbohydrate Metabolism in Agrobacterium tumefaciens

Arthur, Larry O., Bulla, Lee A., Julian, Grant St., Nakamura, Lawrence K.

The activity of pentose cycling (PC) reactions in Agrobacterium tumefaciens is much greater than that normally found in bacteria, and in this regard the organism represents a unique category....

Control of Pantothenate Accumulation in Agrobacterium tumefaciens

Kaneshiro, Tsuneo, Arthur, Larry O., Nickerson, Kenneth W.

Two pantothenate-requiring mutants of Agrobacterium tumefaciens have been isolated. One of them (strain WMP-1) is unusual in that growth levels equivalent to the parent strain are achieved only when...

Monoclonal Antibodies Identify Individual Determinants on Mouse Mammary Tumor Virus Glycoprotein gp52 with Group, Class, or Type Specificity

Massey, Richard J., Arthur, Larry O., Nowinski, Robert C., Schochetman, Gerald

Hybrid cell lines producing monoclonal antibodies against the C3H strain of mouse mammary tumor virus (C3H MMTV) were prepared by the fusion of mouse myeloma cells with the lymphocytes of BALB/c mice...

Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions

Zhu, Ping, Chertova, Elena, Bess, Julian, Lifson, Jeffrey D., Arthur, Larry O., Liu, Jun, ...

We used electron tomography to directly visualize trilobed presumptive envelope (env) glycoprotein structures on the surface of negatively stained HIV type 1 (HIV-1) and simian immunodeficiency virus...

Mice with Spontaneous Mammary Tumors Develop Type-Specific Neutralizing and Cytotoxic Antibodies Against the Mouse Mammary Tumor Virus Envelope Protein gp52

Schochetman, Gerald, Arthur, Larry O., Long, Cedric W., Massey, Richard J.

Sera from C3H mammary tumor-bearing mice contain cytotoxic antibodies for mouse mammary tumor virus (MMTV)-producing cells, based on 51Cr release in a complement-dependent serum cytotoxicity assay....

Establishment of a C3Hf Mammary Tumor Cell Line Expressing Endogenous Mouse Mammary Tumor Virus: Antigenic and Genetic Relationships of This Virus with Highly Oncogenic Mouse Mammary Tumor Viruses

Arthur, Larry O., Lovinger, Gerald G., Schochetman, Gerald

A single-cell clone of C3Hf mammary tumor cells (clone 14) was developed into a continuous cell line expressing high levels of endogenous mouse mammary tumor virus (MMTV) with less than 0.1% murine...

Simian Immunodeficiency Virus Integration Preference Is Similar to That of Human Immunodeficiency Virus Type 1

Crise, Bruce, Li, Yuan, Yuan, Chiuchin, Morcock, David R., Whitby, Denise, Munroe, David J., ...

Simian immunodeficiency virus (SIV) is a useful model for studying human immunodeficiency virus (HIV) pathogenesis and vaccine efficacy. As with all other retroviruses, integration is a necessary...

Oligomeric structure of virion-associated and soluble forms of the simian immunodeficiency virus envelope protein in the prefusion activated conformation

Center, Rob J., Schuck, Peter, Leapman, Richard D., Arthur, Larry O., Earl, Patricia L., Moss, Bernard, ...

The envelope proteins (env) of simian immunodeficiency virus (SIV) and HIV type 1 assemble to form noncovalently associated oligomers in the endoplasmic reticulum. After cleavage in a Golgi...

Ubiquitin Is Covalently Attached to the p6Gag Proteins of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus and to the p12Gag Protein of Moloney Murine Leukemia Virus

Ott, David E., Coren, Lori V., Copeland, Terry D., Kane, Bradley P., Johnson, Donald G., Sowder, Raymond C., ...

Host proteins are incorporated into retroviral virions during assembly and budding. We have examined three retroviruses, human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus...

Protection of Macaca nemestrina from Disease following Pathogenic Simian Immunodeficiency Virus (SIV) Challenge: Utilization of SIV Nucleocapsid Mutant DNA Vaccines with and without an SIV Protein Boost

Gorelick, Robert J., Benveniste, Raoul E., Lifson, Jeffrey D., Yovandich, Jason L., Morton, William R., Kuller, LaRene, ...

Molecular clones were constructed that express nucleocapsid (NC) deletion mutant simian immunodeficiency viruses (SIVs) that are replication defective but capable of completing virtually all of the...

Characterization of the Block in Replication of Nucleocapsid Protein Zinc Finger Mutants from Moloney Murine Leukemia Virus

Gorelick, Robert J., Fu, William, Gagliardi, Tracy D., Bosche, William J., Rein, Alan, Henderson, Louis E., ...

Mutagenesis studies have shown that retroviral nucleocapsid (NC) protein Zn2+ fingers (-Cys-X2-Cys-X4-His-X4-Cys- [CCHC]) perform multiple functions in the virus life cycle. Moloney murine leukemia...

Partial Activation and Induction of Apoptosis in CD4+ and CD8+ T Lymphocytes by Conformationally Authentic Noninfectious Human Immunodeficiency Virus Type 1†

Esser, Mark T., Bess, Julian W., Suryanarayana, Kalachar, Chertova, Elena, Marti, Darlene, Carrington, Mary, ...

Increased levels of apoptosis are seen in human immunodeficiency virus (HIV) infection, and this has been proposed as an important mechanism contributing to HIV pathogenesis. However, interpretation...

Identification of Highly Attenuated Mutants of Simian Immunodeficiency Virus

Desrosiers, Ronald C., Lifson, Jeffrey D., Gibbs, James S., Czajak, Susan C., Howe, Anita Y. M., Arthur, Larry O., ...

Deletion mutants of the pathogenic clone of simian immunodeficiency virus isolate 239 (SIVmac239) were derived that are missing nef, vpr, and upstream sequences (US) in the U3 region of the LTR...

Oligomeric Structure of the Human Immunodeficiency Virus Type 1 Envelope Protein on the Virion Surface

Center, Rob J., Leapman, Richard D., Lebowitz, Jacob, Arthur, Larry O., Earl, Patricia L., Moss, Bernard

The envelope protein (Env) of human immunodeficiency virus type 1 forms homo-oligomers in the endoplasmic reticulum. The oligomeric structure of Env is maintained after cleavage in a Golgi...

Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus

Chertova, Elena, Crise, Bruce J., Sowder II, Raymond C., Schaden, Terra M., Hilburn, Joanne M., ...

Human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) particles typically contain small amounts of the surface envelope protein (SU), and this is widely believed to be...

Control of Viremia and Prevention of Simian-Human Immunodeficiency Virus-Induced Disease in Rhesus Macaques Immunized with Recombinant Vaccinia Viruses plus Inactivated Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Particles

Willey, Ronald L., Byrum, Russ, Piatak, Michael, Kim, Young B., Cho, Michael W., ...

An effective vaccine against the human immunodeficiency virus type 1 (HIV-1) will very likely have to elicit both cellular and humoral immune responses to control HIV-1 strains of diverse geographic...

Cholesterol Depletion of Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus with β-Cyclodextrin Inactivates and Permeabilizes the Virions: Evidence for Virion-Associated Lipid Rafts

Graham, David R. M., Chertova, Elena, Hilburn, Joanne M., Arthur, Larry O., Hildreth, James E. K.

Recent evidence suggests that human immunodeficiency virus type 1 (HIV-1) particles assemble and bud selectively through areas in the plasma membrane of cells that are highly enriched with...

Carbohydrate Catabolism of Selected Strains in the Genus Agrobacterium

Arthur, Larry O., Nakamura, Lawrence K., Julian, Grant St., Bulla, Lee A.

Radiorespirometric and enzyme analyses were used to reveal the glucose-catabolizing mechanisms functioning in single strains of seven presumed Agrobacterium species. The Entner-Doudoroff and pentose...

Carbohydrate Metabolism in Agrobacterium tumefaciens

Arthur, Larry O., Bulla, Lee A., Julian, Grant St., Nakamura, Lawrence K.

The activity of pentose cycling (PC) reactions in Agrobacterium tumefaciens is much greater than that normally found in bacteria, and in this regard the organism represents a unique category....

Control of Pantothenate Accumulation in Agrobacterium tumefaciens

Kaneshiro, Tsuneo, Arthur, Larry O., Nickerson, Kenneth W.

Two pantothenate-requiring mutants of Agrobacterium tumefaciens have been isolated. One of them (strain WMP-1) is unusual in that growth levels equivalent to the parent strain are achieved only when...

Monoclonal Antibodies Identify Individual Determinants on Mouse Mammary Tumor Virus Glycoprotein gp52 with Group, Class, or Type Specificity

Massey, Richard J., Arthur, Larry O., Nowinski, Robert C., Schochetman, Gerald

Hybrid cell lines producing monoclonal antibodies against the C3H strain of mouse mammary tumor virus (C3H MMTV) were prepared by the fusion of mouse myeloma cells with the lymphocytes of BALB/c mice...

Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions

Zhu, Ping, Chertova, Elena, Bess, Julian, Lifson, Jeffrey D., Arthur, Larry O., Liu, Jun, ...

We used electron tomography to directly visualize trilobed presumptive envelope (env) glycoprotein structures on the surface of negatively stained HIV type 1 (HIV-1) and simian immunodeficiency virus...

Mice with Spontaneous Mammary Tumors Develop Type-Specific Neutralizing and Cytotoxic Antibodies Against the Mouse Mammary Tumor Virus Envelope Protein gp52

Schochetman, Gerald, Arthur, Larry O., Long, Cedric W., Massey, Richard J.

Sera from C3H mammary tumor-bearing mice contain cytotoxic antibodies for mouse mammary tumor virus (MMTV)-producing cells, based on 51Cr release in a complement-dependent serum cytotoxicity assay....

Establishment of a C3Hf Mammary Tumor Cell Line Expressing Endogenous Mouse Mammary Tumor Virus: Antigenic and Genetic Relationships of This Virus with Highly Oncogenic Mouse Mammary Tumor Viruses

Arthur, Larry O., Lovinger, Gerald G., Schochetman, Gerald

A single-cell clone of C3Hf mammary tumor cells (clone 14) was developed into a continuous cell line expressing high levels of endogenous mouse mammary tumor virus (MMTV) with less than 0.1% murine...

Simian Immunodeficiency Virus Integration Preference Is Similar to That of Human Immunodeficiency Virus Type 1

Crise, Bruce, Li, Yuan, Yuan, Chiuchin, Morcock, David R., Whitby, Denise, Munroe, David J., ...

Simian immunodeficiency virus (SIV) is a useful model for studying human immunodeficiency virus (HIV) pathogenesis and vaccine efficacy. As with all other retroviruses, integration is a necessary...