Marquard, Vivien, Beckmann, Lars, Heid, Iris M, Lamina, Claudia, Chang-Claude, Jenny
Abstract Background We investigated the influence of genotyping errors on the type I error rate and empirical power of two haplotype based association methods applied to candidate regions. We...
CYP450 polymorphisms as risk factors for early-onset lung cancer: gender-specific differences (2009)
Timofeeva, Maria N., Kropp, Silke, Sauter, Wiebke, Beckmann, Lars, Rosenberger, Albert, Illig, Thomas, ...
Cytochrome P450 (CYP) enzymes, involved in metabolism of tobacco carcinogens, are also involved in estrogen metabolism and many are regulated by estrogens. These genes may thus be of relevance to...
Rietschel, Marcella, Beckmann, Lars, Strohmeier, Jana, Georgi, Alexander, Karpushova, Anna, Schirmbeck, Frederike, ...
OBJECTIVE: G72 is among the most frequently replicated vulnerability genes for schizophrenia and bipolar disorder. The authors previously found identical haplotypes of markers M23 and M24 to be...
Dempfle, Astrid, Hein, Rebecca, Beckmann, Lars, Scherag, André, Nguyen, Thuy, Schäfer, Helmut, ...
Abstract Accounting for interactions with environmental factors in association studies may improve the power to detect genetic effects and may help identifying important environmental effect...
Comparison of measures for haplotype similarity (2007)
Marquard, Vivien, Beckmann, Lars, Bermejo, Justo L, Fischer, Christine, Chang-Claude, Jenny
Abstract Measuring the association of haplotype similarities with phenotype similarities has been used to develop statistical tests of genetic association. Previously, we applied the general approach...
Haplotype-sharing analysis using Mantel statistics for combined genetic effects (2005)
Beckmann, Lars, Fischer, Christine, Obreiter, Markus, Rabes, Michael, Chang-Claude, Jenny
Abstract We applied a new approach based on Mantel statistics to analyze the Genetic Analysis Workshop 14 simulated data with prior knowledge of the answers. The method was developed in order to...
New haplotype sharing and haplotype assignment methods for mapping genes of complex diseases (2004)
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New haplotype sharing and haplotype assignment methods for mapping genes of complex diseases (2004)
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Fischer, Christine, Beckmann, Lars, Majoram, Paul, Meerman, Gerard Te, Chang-Claude, Jenny
Haplotype sharing analysis was used to investigate the association of affection status with single nucleotide polymorphism (SNP) haplotypes within candidate gene 1 in one sample each from the...
Heidelberg, Univ., Diss., 2003.
Minimum-recombinant haplotyping in pedigrees (2002)
This article presents a six-rule algorithm for the reconstruction of multiple minimum-recombinant haplotype configurations in pedigrees. The algorithm has three major features: First, it allows...
Minimum-Recombinant Haplotyping in Pedigrees
This article presents a six-rule algorithm for the reconstruction of multiple minimum-recombinant haplotype configurations in pedigrees. The algorithm has three major features: First, it allows...
Dempfle, Astrid, Hein, Rebecca, Beckmann, Lars, Scherag, André, Nguyen, Thuy Trang, Schäfer, Helmut, ...
Accounting for interactions with environmental factors in association studies may improve the power to detect genetic effects and may help identifying important environmental effect modifiers. The...
Comparison of measures for haplotype similarity
Marquard, Vivien, Beckmann, Lars, Bermejo, Justo L, Fischer, Christine, Chang-Claude, Jenny
Measuring the association of haplotype similarities with phenotype similarities has been used to develop statistical tests of genetic association. Previously, we applied the general approach of...