Herwald, Heiko, Cramer, Henning, Mörgelin, Matthias, Russell, Wayne, Sollenberg, Ulla, Norrby-Teglund, Anna, ...
Abstract is not available
Antimicrobial activities of heparin-binding peptides. (2004)
Andersson, Emma, Rydengård, Victoria, Sonesson, Andreas, Mörgelin, Matthias, Björck, Lars, Schmidtchen, Artur
Antimicrobial peptides are effector molecules of the innate immune system. We recently showed that the human antimicrobial peptides alpha-defensin and LL-37 bind to glycosaminoglycans (heparin and...
Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes. (2004)
Nyberg, Patrik, Sakai, Takao, Cho, Kyu Hong, Caparon, Michael G, Fässler, Reinhard, Björck, Lars
Abstract is not available
Nyberg, Patrik, Rasmussen, Magnus, Björck, Lars
SpeB is a cysteine proteinase and virulence determinant secreted by the important human pathogen Streptococcus pyogenes. Recent investigations have suggested a role for SpeB in streptococcal entry...
Smith, David, D'Argy, Roland, Nilsson, Mats, Yrlid, Ulf, De Jersey, James, Björck, Lars, ...
Abstract is not available
Activation of the complement system generates antibacterial peptides. (2004)
Nordahl, Emma Andersson, Rydengård, Victoria, Nyberg, Patrik, Nitsche, D Patric, Mörgelin, Matthias, Björck, Lars, ...
Abstract is not available
Nyberg, Patrik, Rasmussen, Magnus, Björck, Lars
Abstract is not available
Vincents, Bjarne, Björck, Lars, Abrahamson, Magnus
Abstract is not available
Viau, Muriel, Longo, Nancy S, Lipsky, Peter E, Björck, Lars, Zouali, Moncef
Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B...
Genovese, Arturo, Borgia, Guglielmo, Björck, Lars, Petraroli, Angelica, De Paulis, Amato, Piazza, Marcello, ...
Abstract is not available
Schmidtchen, Artur, Holst, Elisabet, Tapper, Hans, Björck, Lars
Abstract is not available
IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes. (2003)
Abstract is not available
Janulczyk, Robert, Ricci, Susanna, Björck, Lars
Abstract is not available
Staali, Leïla, Mörgelin, Matthias, Björck, Lars, Tapper, Hans
Abstract is not available
Herwald, Heiko, Mörgelin, Matthias, Björck, Lars
Abstract is not available
Johansson, Maria U, Nilsson, Hanna, Evenäs, Johan, Forsén, Sture, Drakenberg, Torbjörn, Björck, Lars, ...
Proteins G and PAB are bacterial albumin-binding proteins expressed at the surface of group C and G streptococci and Peptostreptococcus magnus, respectively. Repeated albumin-binding domains, known...
Structure, specificity, and mode of interaction for bacterial albumin-binding modules. (2002)
Johansson, Maria U, Frick, Inga-Maria, Nilsson, Hanna, Kraulis, Per J, Hober, Sophia, Jonasson, Per, ...
We have determined the solution structure of an albumin binding domain of protein G, a surface protein of group C and G streptococci. We find that it folds into a left handed three-helix bundle...
IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G. (2002)
Johansson, Björn P, Björck, Lars
Recent work from several laboratories has demonstrated that proteolytic mechanisms significantly contribute to the molecular interplay between Streptococcus pyogenes, an important human pathogen, and...
Proteolysis and its regulation at the surface of Streptococcus pyogenes. (2002)
Rasmussen, Magnus, Björck, Lars
Pathogenic bacteria often produce proteinases that are believed to be involved in virulence. Moreover, several host defence systems depend on proteolysis, demonstrating that proteolysis and its...
Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells. (2002)
Frick, Inga-Maria, Axcrona, Karol, Härdig, Ylva, Tapper, Hans, Gustafsson, Lotta, Kellner, Roland, ...
Some strains of the human pathogen Streptococcus pyogenes express a surface protein called protein H, which is released from the streptococcal surface by a cysteine proteinase produced by the...
Mattsson, Eva, Herwald, Heiko, Björck, Lars, Egesten, Arne
Staphylococcus aureus is one of the most significant pathogens in human sepsis and endocarditis. S. aureus can initiate blood coagulation, leading to the formation of microthrombi and multiorgan...
Ricci, Susanna, Janulczyk, Robert, Björck, Lars
Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the...
Schmidtchen, Artur, Frick, Inga-Maria, Andersson, Emma, Tapper, Hans, Björck, Lars
Effectors of the innate immune system, the anti-bacterial peptides, have pivotal roles in preventing infection at epithelial surfaces. Here we show that proteinases of the significant human pathogens...
Protein H, an Antiphagocytic Surface Protein in Streptococcus pyogenes
Kihlberg, Britt-Marie, Collin, Mattias, Olsén, Arne, Björck, Lars
Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional...
SclA, a Novel Collagen-Like Surface Protein of Streptococcus pyogenes
Rasmussen, Magnus, Edén, Arvid, Björck, Lars
Surface proteins of Streptococcus pyogenes are important virulence factors. Here we describe a novel collagen-like surface protein, designated SclA (streptococcal collagen-like surface protein). The...
Staphylococcus aureus Induces Release of Bradykinin in Human Plasma
Mattsson, Eva, Herwald, Heiko, Cramer, Henning, Persson, Kristin, Sjöbring, Ulf, Björck, Lars
Staphylococcus aureus is a prominent human pathogen. Here we report that intact S. aureus bacteria activate the contact system in human plasma in vitro, resulting in a massive release of the potent...
Genovese, Arturo, Bouvet, Jean-Pierre, Florio, Giovanni, Lamparter-Schummert, Bärbel, Björck, Lars, Marone, Gianni
Human heart mast cells (HHMC) have been identified in heart tissue, perivascularly, and in the intima of coronary arteries. In vitro activation of isolated HHMC induces the release of vasoactive and...
Olsén, Arne, Wick, Mary Jo, Mörgelin, Matthias, Björck, Lars
Curli are thin, coiled fibers expressed on the surface of Escherichia coli that bind several matrix and plasma proteins such as fibronectin, laminin, plasminogen, tissue plasminogen activator, and...
Berge, Andreas, Rasmussen, Magnus, Björck, Lars
An insertion sequence, IS1562, was identified in a Streptococcus pyogenes strain of the clinically important M1 serotype. IS1562 is located in the mga regulon between the genes coding for the M...
IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G
Johansson, Björn P., Björck, Lars
Recent work from several laboratories has demonstrated that proteolytic mechanisms significantly contribute to the molecular interplay between Streptococcus pyogenes, an important human pathogen, and...
Mattsson, Eva, Herwald, Heiko, Björck, Lars, Egesten, Arne
Staphylococcus aureus is one of the most significant pathogens in human sepsis and endocarditis. S. aureus can initiate blood coagulation, leading to the formation of microthrombi and multiorgan...
Ricci, Susanna, Janulczyk, Robert, Björck, Lars
Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the...
Janulczyk, Robert, Ricci, Susanna, Björck, Lars
MtsABC is a Streptococcus pyogenes ABC transporter which was previously shown to be involved in iron and zinc accumulation. In this study, we showed that an mtsABC mutant has impaired growth,...
Viau, Muriel, Longo, Nancy S., Lipsky, Peter E., Björck, Lars, Zouali, Moncef
Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B...
Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes
Nyberg, Patrik, Sakai, Takao, Cho, Kyu Hong, Caparon, Michael G, Fässler, Reinhard, Björck, Lars
Fibronectin-binding surface proteins are found in many bacterial species. Most strains of Streptococcus pyogenes, a major human pathogen, express the fibronectin-binding protein F1, which promotes...
Activation of the complement system generates antibacterial peptides
Nordahl, Emma Andersson, Rydengård, Victoria, Nyberg, Patrik, Nitsche, D. Patric, Mörgelin, Matthias, Malmsten, Martin, ...
The complement system represents an evolutionary old and significant part of the innate immune system involved in protection against invading microorganisms. Here, we show that the anaphylatoxin C3a...
Wenig, Katja, Chatwell, Lorenz, Björck, Lars, Huber, Robert, Sondermann, Peter
Pathogenic bacteria have developed complex and diverse virulence mechanisms that weaken or disable the host immune defense system. IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted...
Protein H, an Antiphagocytic Surface Protein in Streptococcus pyogenes
Kihlberg, Britt-Marie, Collin, Mattias, Olsén, Arne, Björck, Lars
Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional...
SclA, a Novel Collagen-Like Surface Protein of Streptococcus pyogenes
Rasmussen, Magnus, Edén, Arvid, Björck, Lars
Surface proteins of Streptococcus pyogenes are important virulence factors. Here we describe a novel collagen-like surface protein, designated SclA (streptococcal collagen-like surface protein). The...
Staphylococcus aureus Induces Release of Bradykinin in Human Plasma
Mattsson, Eva, Herwald, Heiko, Cramer, Henning, Persson, Kristin, Sjöbring, Ulf, Björck, Lars
Staphylococcus aureus is a prominent human pathogen. Here we report that intact S. aureus bacteria activate the contact system in human plasma in vitro, resulting in a massive release of the potent...
Genovese, Arturo, Bouvet, Jean-Pierre, Florio, Giovanni, Lamparter-Schummert, Bärbel, Björck, Lars, Marone, Gianni
Human heart mast cells (HHMC) have been identified in heart tissue, perivascularly, and in the intima of coronary arteries. In vitro activation of isolated HHMC induces the release of vasoactive and...
Olsén, Arne, Wick, Mary Jo, Mörgelin, Matthias, Björck, Lars
Curli are thin, coiled fibers expressed on the surface of Escherichia coli that bind several matrix and plasma proteins such as fibronectin, laminin, plasminogen, tissue plasminogen activator, and...
Berge, Andreas, Rasmussen, Magnus, Björck, Lars
An insertion sequence, IS1562, was identified in a Streptococcus pyogenes strain of the clinically important M1 serotype. IS1562 is located in the mga regulon between the genes coding for the M...
IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G
Johansson, Björn P., Björck, Lars
Recent work from several laboratories has demonstrated that proteolytic mechanisms significantly contribute to the molecular interplay between Streptococcus pyogenes, an important human pathogen, and...
Mattsson, Eva, Herwald, Heiko, Björck, Lars, Egesten, Arne
Staphylococcus aureus is one of the most significant pathogens in human sepsis and endocarditis. S. aureus can initiate blood coagulation, leading to the formation of microthrombi and multiorgan...
Ricci, Susanna, Janulczyk, Robert, Björck, Lars
Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the...
Janulczyk, Robert, Ricci, Susanna, Björck, Lars
MtsABC is a Streptococcus pyogenes ABC transporter which was previously shown to be involved in iron and zinc accumulation. In this study, we showed that an mtsABC mutant has impaired growth,...
Viau, Muriel, Longo, Nancy S., Lipsky, Peter E., Björck, Lars, Zouali, Moncef
Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B...
Interactions with fibronectin attenuate the virulence of Streptococcus pyogenes
Nyberg, Patrik, Sakai, Takao, Cho, Kyu Hong, Caparon, Michael G, Fässler, Reinhard, Björck, Lars
Fibronectin-binding surface proteins are found in many bacterial species. Most strains of Streptococcus pyogenes, a major human pathogen, express the fibronectin-binding protein F1, which promotes...
Activation of the complement system generates antibacterial peptides
Nordahl, Emma Andersson, Rydengård, Victoria, Nyberg, Patrik, Nitsche, D. Patric, Mörgelin, Matthias, Malmsten, Martin, ...
The complement system represents an evolutionary old and significant part of the innate immune system involved in protection against invading microorganisms. Here, we show that the anaphylatoxin C3a...
Wenig, Katja, Chatwell, Lorenz, Björck, Lars, Huber, Robert, Sondermann, Peter
Pathogenic bacteria have developed complex and diverse virulence mechanisms that weaken or disable the host immune defense system. IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted...
The contact system—a novel branch of innate immunity generating antibacterial peptides
Frick, Inga-Maria, Åkesson, Per, Herwald, Heiko, Mörgelin, Matthias, Malmsten, Martin, Nägler, Dorit K, ...
Activation of the contact system has two classical consequences: initiation of the intrinsic pathway of coagulation, and cleavage of high molecular weight kininogen (HK) leading to the release of...
Deoxyribonucleoside Kinases Activate Nucleoside Antibiotics in Severely Pathogenic Bacteria▿
Sandrini, Michael P. B., Shannon, Oonagh, Clausen, Anders R., Björck, Lars, Piškur, Jure
Common bacterial pathogens are becoming progressively more resistant to traditional antibiotics, representing a major public-health crisis. Therefore, there is a need for a variety of antibiotics...
Severe Lung Lesions Caused by Salmonella Are Prevented by Inhibition of the Contact System
Persson, Kristin, Mörgelin, Matthias, Lindbom, Lennart, Alm, Per, Björck, Lars, Herwald, Heiko
Vascular damage induced by trauma, inflammation, or infection results in an alteration of the endothelium from a nonactivated to a procoagulant, vasoconstrictive, and proinflammatory state, and can...
Kahn, Fredrik, Mörgelin, Matthias, Shannon, Oonagh, Norrby-Teglund, Anna, Herwald, Heiko, Olin, Anders I., ...
Streptococcal toxic shock syndrome (STSS) caused by Streptococcus pyogenes is a clinical condition with a high mortality rate despite modern intensive care. A key feature of STSS is excessive plasma...
IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions
Collin, Mattias, Shannon, Oonagh, Björck, Lars
EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely...
Frick, Inga-Maria, Karlsson, Christofer, Mörgelin, Matthias, Olin, Anders I, Janjusevic, Radmila, Hammarström, Clara, ...
Anaerobic bacteria dominate the human normal microbiota, but strikingly little is known about these commensals. Finegoldia magna is a Gram-positive anaerobe found in the skin and at other non-sterile...
Lange, Vinzenz, Malmström, Johan A., Didion, John, King, Nichole L., Johansson, Björn P., Schäfer, Juliane, ...
In many studies, particularly in the field of systems biology, it is essential that identical protein sets are precisely quantified in multiple samples such as those representing differentially...