Maaser, Christian, Housley, Michael P., Iimura, Mitsutoshi, Smith, Jennifer R., Vallance, Bruce A., Finlay, B. Brett, ...
Citrobacter rodentium, a murine model pathogen for human enteropathogenic Escherichia coli, predominantly colonizes the lumen and mucosal surface of the colon and cecum and causes crypt hyperplasia...
Pathogenese der Murinen Retrovirus-Induzierten Malignen Histiozytose / (1991)
Thesis (doctoral)--Universität Hamburg, 1991.
Eckmann, Lars, Rudolf, Marco T., Ptasznik, Andrzej, Schultz, Carsten, Jiang, Tao, Wolfson, Nora, ...
Several inositol-containing compounds play key roles in receptor-mediated cell signaling events. Here, we describe a function for a specific inositol polyphosphate, d-myo-inositol...
Lowe, David C., Savidge, Tor C., Pickard, Derek, Eckmann, Lars, Kagnoff, Martin F., Dougan, Gordon, ...
The properties of two candidate Salmonella typhi-based live oral typhoid vaccine strains, BRD691 (S. typhi Ty2 harboring mutations in aroA and aroC) and BRD1116 (S. typhi Ty2 harboring mutations in...
Chemokine Secretion of Human Cells in Response to Toxoplasma gondii Infection
Denney, Carolyn F., Eckmann, Lars, Reed, Sharon L.
The ubiquitous protozoan parasite Toxoplasma gondii is a major cause of morbidity and mortality in neonates and immunocompromised hosts. Both acute invasion and reactivation of latent infection...
Intestinal Epithelial Cell Apoptosis following Cryptosporidium parvum Infection
McCole, Declan F., Eckmann, Lars, Laurent, Fabrice, Kagnoff, Martin F.
Cryptosporidium parvum induces moderate levels of apoptosis of cultured human intestinal epithelial cells, which are maximal at 24 h after infection. Apoptosis is further increased in C....
Weintraub, Bennett C., Eckmann, Lars, Okamoto, Sharon, Hense, Marc, Hedrick, Stephen M., Fierer, Joshua
Laurent, Fabrice, Kagnoff, Martin F., Savidge, Tor C., Naciri, Muriel, Eckmann, Lars
Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of...
Importance of Interleukin-10 in Genetic Susceptibility of Mice to Coccidioides immitis
Fierer, Joshua, Walls, Lorraine, Eckmann, Lars, Yamamoto, Tomoko, Kirkland, Theo N.
Inbred strains of mice vary in their susceptibility to Coccidioides immitis. We infected resistant DBA/2 (D2) mice and three susceptible strains of mice (C57BL/6 [B6], BALB/c, and CAST/Ei) by...
Central Importance of Immunoglobulin A in Host Defense against Giardia spp.
Langford, T. Dianne, Housley, Michael P., Boes, Marianne, Chen, Jianzhu, Kagnoff, Martin F., Gillin, Frances D., ...
The protozoan pathogen Giardia is an important cause of parasitic diarrheal disease worldwide. It colonizes the lumen of the small intestine, suggesting that effective host defenses must act...
Hase, Koji, Eckmann, Lars, Leopard, John D., Varki, Nissi, Kagnoff, Martin F.
Antimicrobial peptides are highly conserved evolutionarily and are thought to play an important role in innate immunity at intestinal mucosal surfaces. To better understand the role of the...
A Surface Amebic Cysteine Proteinase Inactivates Interleukin-18
Que, Xuchu, Kim, Soo-Hyun, Sajid, Mohammed, Eckmann, Lars, Dinarello, Charles A., McKerrow, James H., ...
Amebiasis is a major cause of morbidity and mortality worldwide. Invasion by Entamoeba histolytica trophozoites causes secretion of proinflammatory cytokines from host epithelial cells, leading to a...
Bertelsen, Lone S., Paesold, Guenther, Eckmann, Lars, Barrett, Kim E.
Enteric Salmonella infection is accompanied by inflammation and diarrhea, and yet little is known about its effects on intestinal epithelial physiology. Since species differences limit the utility of...
Nishihara, Hiroshi, Kizaka-Kondoh, Shinae, Insel, Paul A., Eckmann, Lars
Cyclooxygenase (COX)-2, a rate-limiting enzyme of prostaglandin (PG) production, is overexpressed in colorectal adenomas and adenocarcinomas, and its inhibition by nonsteroidal antiinflammatory drugs...
IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium
Egan, Laurence J., Eckmann, Lars, Greten, Florian R., Chae, Sungwon, Li, Zhi-Wei, Myhre, Gennett M., ...
Acute injury to the intestinal mucosa is a major dose-limiting complication of abdominal radiation therapy. We studied the role of the transcription factor NF-κB in protection against...
Maaser, Christian, Housley, Michael P., Iimura, Mitsutoshi, Smith, Jennifer R., Vallance, Bruce A., Finlay, B. Brett, ...
Citrobacter rodentium, a murine model pathogen for human enteropathogenic Escherichia coli, predominantly colonizes the lumen and mucosal surface of the colon and cecum and causes crypt hyperplasia...
Toll-like receptor 9–induced type I IFN protects mice from experimental colitis
Katakura, Kyoko, Lee, Jongdae, Rachmilewitz, Daniel, Li, Gloria, Eckmann, Lars, Raz, Eyal
Experimental colitis is mediated by inflammatory or dysregulated immune responses to microbial factors of the gastrointestinal tract. In this study we observed that administration of Toll-like...
Toll-like receptor 9–induced type I IFN protects mice from experimental colitis
Katakura, Kyoko, Lee, Jongdae, Rachmilewitz, Daniel, Li, Gloria, Eckmann, Lars, Raz, Eyal
Tumor promotion by caspase-resistant retinoblastoma protein
Borges, Helena L., Bird, Jeff, Wasson, Katherine, Cardiff, Robert D., Varki, Nissi, Eckmann, Lars, ...
The retinoblastoma (RB) protein regulates cell proliferation and cell death. RB is cleaved by caspase during apoptosis. A mutation of the caspase-cleavage site in the RB C terminus has been made in...
Andersen, Yolanda S., Gillin, Frances D., Eckmann, Lars
Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that...
Eckmann, Lars, Rudolf, Marco T., Ptasznik, Andrzej, Schultz, Carsten, Jiang, Tao, Wolfson, Nora, ...
Several inositol-containing compounds play key roles in receptor-mediated cell signaling events. Here, we describe a function for a specific inositol polyphosphate, d-myo-inositol...
Lowe, David C., Savidge, Tor C., Pickard, Derek, Eckmann, Lars, Kagnoff, Martin F., Dougan, Gordon, ...
The properties of two candidate Salmonella typhi-based live oral typhoid vaccine strains, BRD691 (S. typhi Ty2 harboring mutations in aroA and aroC) and BRD1116 (S. typhi Ty2 harboring mutations in...
Chemokine Secretion of Human Cells in Response to Toxoplasma gondii Infection
Denney, Carolyn F., Eckmann, Lars, Reed, Sharon L.
The ubiquitous protozoan parasite Toxoplasma gondii is a major cause of morbidity and mortality in neonates and immunocompromised hosts. Both acute invasion and reactivation of latent infection...
Intestinal Epithelial Cell Apoptosis following Cryptosporidium parvum Infection
McCole, Declan F., Eckmann, Lars, Laurent, Fabrice, Kagnoff, Martin F.
Cryptosporidium parvum induces moderate levels of apoptosis of cultured human intestinal epithelial cells, which are maximal at 24 h after infection. Apoptosis is further increased in C....
Weintraub, Bennett C., Eckmann, Lars, Okamoto, Sharon, Hense, Marc, Hedrick, Stephen M., Fierer, Joshua
Laurent, Fabrice, Kagnoff, Martin F., Savidge, Tor C., Naciri, Muriel, Eckmann, Lars
Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulating intestinal fluid secretion in animal models of...
Importance of Interleukin-10 in Genetic Susceptibility of Mice to Coccidioides immitis
Fierer, Joshua, Walls, Lorraine, Eckmann, Lars, Yamamoto, Tomoko, Kirkland, Theo N.
Inbred strains of mice vary in their susceptibility to Coccidioides immitis. We infected resistant DBA/2 (D2) mice and three susceptible strains of mice (C57BL/6 [B6], BALB/c, and CAST/Ei) by...
Central Importance of Immunoglobulin A in Host Defense against Giardia spp.
Langford, T. Dianne, Housley, Michael P., Boes, Marianne, Chen, Jianzhu, Kagnoff, Martin F., Gillin, Frances D., ...
The protozoan pathogen Giardia is an important cause of parasitic diarrheal disease worldwide. It colonizes the lumen of the small intestine, suggesting that effective host defenses must act...
Hase, Koji, Eckmann, Lars, Leopard, John D., Varki, Nissi, Kagnoff, Martin F.
Antimicrobial peptides are highly conserved evolutionarily and are thought to play an important role in innate immunity at intestinal mucosal surfaces. To better understand the role of the...
A Surface Amebic Cysteine Proteinase Inactivates Interleukin-18
Que, Xuchu, Kim, Soo-Hyun, Sajid, Mohammed, Eckmann, Lars, Dinarello, Charles A., McKerrow, James H., ...
Amebiasis is a major cause of morbidity and mortality worldwide. Invasion by Entamoeba histolytica trophozoites causes secretion of proinflammatory cytokines from host epithelial cells, leading to a...
Bertelsen, Lone S., Paesold, Guenther, Eckmann, Lars, Barrett, Kim E.
Enteric Salmonella infection is accompanied by inflammation and diarrhea, and yet little is known about its effects on intestinal epithelial physiology. Since species differences limit the utility of...
Nishihara, Hiroshi, Kizaka-Kondoh, Shinae, Insel, Paul A., Eckmann, Lars
Cyclooxygenase (COX)-2, a rate-limiting enzyme of prostaglandin (PG) production, is overexpressed in colorectal adenomas and adenocarcinomas, and its inhibition by nonsteroidal antiinflammatory drugs...
IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium
Egan, Laurence J., Eckmann, Lars, Greten, Florian R., Chae, Sungwon, Li, Zhi-Wei, Myhre, Gennett M., ...
Acute injury to the intestinal mucosa is a major dose-limiting complication of abdominal radiation therapy. We studied the role of the transcription factor NF-κB in protection against...
Maaser, Christian, Housley, Michael P., Iimura, Mitsutoshi, Smith, Jennifer R., Vallance, Bruce A., Finlay, B. Brett, ...
Citrobacter rodentium, a murine model pathogen for human enteropathogenic Escherichia coli, predominantly colonizes the lumen and mucosal surface of the colon and cecum and causes crypt hyperplasia...
Toll-like receptor 9–induced type I IFN protects mice from experimental colitis
Katakura, Kyoko, Lee, Jongdae, Rachmilewitz, Daniel, Li, Gloria, Eckmann, Lars, Raz, Eyal
Experimental colitis is mediated by inflammatory or dysregulated immune responses to microbial factors of the gastrointestinal tract. In this study we observed that administration of Toll-like...
Toll-like receptor 9–induced type I IFN protects mice from experimental colitis
Katakura, Kyoko, Lee, Jongdae, Rachmilewitz, Daniel, Li, Gloria, Eckmann, Lars, Raz, Eyal
Tumor promotion by caspase-resistant retinoblastoma protein
Borges, Helena L., Bird, Jeff, Wasson, Katherine, Cardiff, Robert D., Varki, Nissi, Eckmann, Lars, ...
The retinoblastoma (RB) protein regulates cell proliferation and cell death. RB is cleaved by caspase during apoptosis. A mutation of the caspase-cleavage site in the RB C terminus has been made in...
Andersen, Yolanda S., Gillin, Frances D., Eckmann, Lars
Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that...
Maaser, Christian, Egan, Laurence J, Birkenbach, Mark P, Eckmann, Lars, Kagnoff, Martin F
Antigen-presenting cells, including dendritic cells, monocytes and macrophages, produce members of the interleukin-12 (IL-12) family that are important in initiating and maintaining cell-mediated...
Meléndez-López, Samuel G., Herdman, Scott, Hirata, Ken, Choi, Min-Ho, Choe, Youngchool, Craik, Charles, ...
Cysteine proteinases are key virulence factors of the protozoan parasite Entamoeba histolytica. We have shown that cysteine proteinases play a central role in tissue invasion and disruption of host...
Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
Abe, Kazumichi, Nguyen, Kim Phung, Fine, Sean D., Mo, Ji-Hun, Shen, Carol, Shenouda, Steve, ...
We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation...
Nod2 Mediates Susceptibility to Yersinia pseudotuberculosis in Mice
Meinzer, Ulrich, Esmiol-Welterlin, Sophie, Barreau, Frederick, Berrebi, Dominique, Dussaillant, Monique, Bonacorsi, Stephane, ...
Nucleotide oligomerisation domain 2 (NOD2) is a component of the innate immunity known to be involved in the homeostasis of Peyer patches (PPs) in mice. However, little is known about its role during...
Hsu, Li-Chung, Ali, Syed R., McGillivray, Shauna, Tseng, Ping-Hui, Mariathasan, Sanjeev, Humke, Eric W., ...
NOD2, a NOD-like receptor (NLR), is an intracellular sensor of bacterial muramyl dipeptide (MDP) that was suggested to promote secretion of the proinflammatory cytokine IL-1β. Yet, the molecular...