Dzhambazov, Balik, Nandakumar, Kutty Selva, Kihlberg, Jan, Fugger, Lars, Holmdahl, Rikard, Vestberg, Mikael
Abstract is not available
The value of animal models for drug development in multiple sclerosis (2006)
Friese, Manuel A., Montalban, Xavier, Willcox, Nick, Bell, John I., Martin, Roland, Fugger, Lars
The rodent model for multiple sclerosis, experimental allergic (autoimmune) encephalomyelitis (EAE), has been used to dissect molecular mechanisms of the autoimmune inflammatory response, and hence...
The value of animal models for drug development in multiple sclerosis (2006)
Friese, Manuel A., Montalban, Xavier, Willcox, Nick, Bell, John I., Martin, Roland, Fugger, Lars
The rodent model for multiple sclerosis, experimental allergic (autoimmune) encephalomyelitis (EAE), has been used to dissect molecular mechanisms of the autoimmune inflammatory response, and hence...
Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? (2005)
Friese, Manuel A., Fugger, Lars
Multiple sclerosis afflicts more than 1 million individuals worldwide and is widely considered to be an autoimmune disease. Traditionally, CD4+ T helper cells have almost exclusively been held...
Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy? (2005)
Friese, Manuel A., Fugger, Lars
Multiple sclerosis afflicts more than 1 million individuals worldwide and is widely considered to be an autoimmune disease. Traditionally, CD4+ T helper cells have almost exclusively been held...
Bäcklund, Johan, Carlsen, Stefan, Höger, Torsten, Holm, Björn, Fugger, Lars, Kihlberg, Jan, ...
Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and is characterized by a chronic autoimmune response in the joints. Using transgenic mice expressing human DR4 (DRB1*0401)...
Abstract Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these...
Joint-specific and systemic autoreactivity in the development of inflammatory arthritis (1999)
No abstract available.
MspI polymorphism in the human interleukin 6 (IL 6) gene (1989)
Fugger, Lars, Morling, Niels, Bendtzen, Klaus, Ryder, Lars, Ødum, Niels, Georgsen, Jørgen, ...
Mice lacking all conventional MHC class II genes
Madsen, Lars, Labrecque, Nathalie, Engberg, Jan, Dierich, Andrée, Svejgaard, Arne, Benoist, Christophe, ...
MHC class II (MHC-II) molecules play a central role in the selection of the T cell repertoire, in the establishment and regulation of the adaptive immune response, and in autoimmune deviation. We...
Reiter, Yoram, Di Carlo, Angelina, Fugger, Lars, Engberg, Jan, Pastan, Ira
Specificity in the immune system is dictated and regulated by specific recognition of peptide/major histocompatibility complex (MHC) complexes by the T cell receptor. Such peptide/MHC complexes are a...
Patel, Salil D., Cope, Andrew P., Congia, Mauro, Chen, Teddy T., Kim, Eugene, Fugger, Lars, ...
Glutamic acid decarboxylase isoform 2 (GAD65; EC 4.1.1.15) has been identified as a key target autoantigen of insulin-dependent diabetes mellitus (IDDM). IDDM is genetically associated with the major...
Andersson, Ellen Christina, Hansen, Bjarke Endel, Jacobsen, Helle, Madsen, Lars S., Andersen, Claus B., Engberg, Jan, ...
Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II collagen (CII) is a candidate, and the DR4- and...
Fridkis-Hareli, Masha, Rosloniec, Edward F., Fugger, Lars, Strominger, Jack L.
Copolymer 1 [poly(Y,E,A,K)] is a random synthetic amino acid copolymer of l-tyrosine, l-glutamic acid, l-alanine, and l-lysine that is effective both in suppression of experimental allergic...
Röpke, Mads, Hald, Jesper, Guldberg, Per, Zeuthen, Jesper, Nørgaard, Lars, Fugger, Lars, ...
A cytotoxic T lymphocyte (CTL) clone generated in vitro from the peripheral blood of a healthy HLA-A2-positive individual against a synthetic p53 protein-derived wild-type peptide (L9V) was shown to...
Bäcklund, Johan, Carlsen, Stefan, Höger, Torsten, Holm, Björn, Fugger, Lars, Kihlberg, Jan, ...
Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and is characterized by a chronic autoimmune response in the joints. Using transgenic mice expressing human DR4 (DRB1*0401)...
Fugger , Lars, Svejgaard, Arne
Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major...
Fridkis-Hareli, Masha, Santambrogio, Laura, Stern, Joel N.H., Fugger, Lars, Brosnan, Celia, Strominger, Jack L.
Copolymer 1 (Cop 1, Copaxone [Teva Marion Partners, Kansas City, Missouri, USA]), a random amino acid copolymer of tyrosine (Y), glutamic acid (E), alanine (A), and lysine (K), reduces the frequency...
Siebold, Christian, Hansen, Bjarke E., Wyer, Jessica R., Harlos, Karl, Esnouf, Robert E., Svejgaard, Arne, ...
The MHC class II molecule DQ0602 confers strong susceptibility to narcolepsy but dominant protection against type 1 diabetes. The crystal structure of DQ0602 reveals the molecular features underlying...
Mice lacking all conventional MHC class II genes
Madsen, Lars, Labrecque, Nathalie, Engberg, Jan, Dierich, Andrée, Svejgaard, Arne, Benoist, Christophe, ...
MHC class II (MHC-II) molecules play a central role in the selection of the T cell repertoire, in the establishment and regulation of the adaptive immune response, and in autoimmune deviation. We...
Reiter, Yoram, Di Carlo, Angelina, Fugger, Lars, Engberg, Jan, Pastan, Ira
Specificity in the immune system is dictated and regulated by specific recognition of peptide/major histocompatibility complex (MHC) complexes by the T cell receptor. Such peptide/MHC complexes are a...
Patel, Salil D., Cope, Andrew P., Congia, Mauro, Chen, Teddy T., Kim, Eugene, Fugger, Lars, ...
Glutamic acid decarboxylase isoform 2 (GAD65; EC 4.1.1.15) has been identified as a key target autoantigen of insulin-dependent diabetes mellitus (IDDM). IDDM is genetically associated with the major...
Andersson, Ellen Christina, Hansen, Bjarke Endel, Jacobsen, Helle, Madsen, Lars S., Andersen, Claus B., Engberg, Jan, ...
Rheumatoid arthritis (RA) is an autoimmune disease associated with the HLA-DR4 and DR1 alleles. The target autoantigen(s) in RA is unknown, but type II collagen (CII) is a candidate, and the DR4- and...
Fridkis-Hareli, Masha, Rosloniec, Edward F., Fugger, Lars, Strominger, Jack L.
Copolymer 1 [poly(Y,E,A,K)] is a random synthetic amino acid copolymer of l-tyrosine, l-glutamic acid, l-alanine, and l-lysine that is effective both in suppression of experimental allergic...
Röpke, Mads, Hald, Jesper, Guldberg, Per, Zeuthen, Jesper, Nørgaard, Lars, Fugger, Lars, ...
A cytotoxic T lymphocyte (CTL) clone generated in vitro from the peripheral blood of a healthy HLA-A2-positive individual against a synthetic p53 protein-derived wild-type peptide (L9V) was shown to...
Bäcklund, Johan, Carlsen, Stefan, Höger, Torsten, Holm, Björn, Fugger, Lars, Kihlberg, Jan, ...
Rheumatoid arthritis (RA) is associated with certain MHC class II alleles and is characterized by a chronic autoimmune response in the joints. Using transgenic mice expressing human DR4 (DRB1*0401)...
Fugger , Lars, Svejgaard, Arne
Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major...
Fridkis-Hareli, Masha, Santambrogio, Laura, Stern, Joel N.H., Fugger, Lars, Brosnan, Celia, Strominger, Jack L.
Copolymer 1 (Cop 1, Copaxone [Teva Marion Partners, Kansas City, Missouri, USA]), a random amino acid copolymer of tyrosine (Y), glutamic acid (E), alanine (A), and lysine (K), reduces the frequency...
Siebold, Christian, Hansen, Bjarke E., Wyer, Jessica R., Harlos, Karl, Esnouf, Robert E., Svejgaard, Arne, ...
The MHC class II molecule DQ0602 confers strong susceptibility to narcolepsy but dominant protection against type 1 diabetes. The crystal structure of DQ0602 reveals the molecular features underlying...
Control of hypothalamic orexin neurons by acid and CO2
Williams, Rhîannan H., Jensen, Lise T., Verkhratsky, Alex, Fugger, Lars, Burdakov, Denis
Hypothalamic orexin/hypocretin neurons recently emerged as key orchestrators of brain states and adaptive behaviors. They are critical for normal stimulation of wakefulness and breathing: Orexin loss...
Krogsgaard, Michelle, Wucherpfennig, Kai W., Canella, Barbara, Hansen, Bjarke E., Svejgaard, Arne, Pyrdol, Jason, ...
Susceptibility to multiple sclerosis (MS) is associated with the human histocompatibility leukocyte antigen (HLA)-DR2 haplotype, suggesting that major histocompatibility complex class II–restricted...
Tzartos, John S., Friese, Manuel A., Craner, Matthew J., Palace, Jackie, Newcombe, Jia, Esiri, Margaret M., ...
Recent findings in the animal model for multiple sclerosis (MS), experimental autoimmune encephalomyelitis, implicate a novel CD4+ T-cell subset (TH17), characterized by the secretion of...
Adaptive sugar sensors in hypothalamic feeding circuits
Williams, Rhiannan H., Alexopoulos, Haris, Jensen, Lise T., Fugger, Lars, Burdakov, Denis
Brain glucose sensing is critical for healthy energy balance, but how appropriate neurocircuits encode both small changes and large background values of glucose levels is unknown. Here, we report...
Metabolism-Independent Sugar Sensing in Central Orexin Neurons
González, J. Antonio, Jensen, Lise T., Fugger, Lars, Burdakov, Denis
OBJECTIVE— Glucose sensing by specialized neurons of the hypothalamus is vital for normal energy balance. In many glucose-activated neurons, glucose metabolism is considered a critical step in...