Lars Hellman

The extended substrate specificity of the human mast cell chymase reveals a serine protease with well-defined substrate recognition profile (2009)

Andersson, Mattias K., Enoksson, Mattias, Gallwitz, Maike, Hellman, Lars

The human chymase (HC) is a major granule constituent of mast cells (MCs) residing in the connective tissue and the sub-mucosa. Although many potential substrates have been described for this...

Isolation of monotreme T-cell receptor α and β chains (2004)

Belov, Katherine, Australian Museum, Miller, Robert D., Ilijeski, Aron, Hellman, Lars, ...

Monotremes are an ancient mammalian lineage that last shared a common ancestor with the marsupial and eutherian (placental) mammals about 170 million years ago. Characterization of their immune genes...

Isolation of monotreme T-cell receptor α and β chains (2004)

Belov, Katherine, Australian Museum, Miller, Robert D., Ilijeski, Aron, Hellman, Lars, ...

Monotremes are an ancient mammalian lineage that last shared a common ancestor with the marsupial and eutherian (placental) mammals about 170 million years ago. Characterization of their immune genes...

KRAB Zinc Finger Proteins: An Analysis of the Molecular Mechanisms Governing Their Increase in Numbers and Complexity During Evolution (2002)

Looman, Camilla, Åbrink, Magnus, Mark, Charlotta, Hellman, Lars

Krüppel-related zinc finger proteins, with 564 members in the human genome, probably constitute the largest individual family of transcription factors in mammals. Approximately 30% of these...

Structure and evolution of the heavy chain from rat immunoglobulin E (1982)

Hellman, Lars, Pettersson, Ulf, Engström, Åke, Karlsson, Torbjörn, Bennich, Hans

The nucleotide sequence of the rat ϵ-chain mRNA has been determined by sequencing cloned cDNA copies of the mRNA. The established sequence covers the coding region, the 3′-non coding region...

Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 β

Abrink, Magnus, Ortiz, José A., Mark, Charlotta, Sanchez, Cecilia, Looman, Camilla, Hellman, Lars, ...

The Krüppel-associated box (KRAB) domain, originally identified as a 75-aa sequence present in numerous Krüppel-type zinc-finger proteins, is a potent DNA-binding-dependent transcriptional...

Loss of Histochemical Identity in Mast Cells Lacking Carboxypeptidase A

Feyerabend, Thorsten B., Hausser, Heinz, Tietz, Annette, Blum, Carmen, Hellman, Lars, Straus, Anita H., ...

Mast cell carboxypeptidase A (Mc-cpa) is a highly conserved secretory granule protease. The onset of expression in mast cell progenitors and lineage specificity suggest an important role for Mc-cpa...

Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 β

Abrink, Magnus, Ortiz, José A., Mark, Charlotta, Sanchez, Cecilia, Looman, Camilla, Hellman, Lars, ...

The Krüppel-associated box (KRAB) domain, originally identified as a 75-aa sequence present in numerous Krüppel-type zinc-finger proteins, is a potent DNA-binding-dependent transcriptional...

Loss of Histochemical Identity in Mast Cells Lacking Carboxypeptidase A

Feyerabend, Thorsten B., Hausser, Heinz, Tietz, Annette, Blum, Carmen, Hellman, Lars, Straus, Anita H., ...

Mast cell carboxypeptidase A (Mc-cpa) is a highly conserved secretory granule protease. The onset of expression in mast cell progenitors and lineage specificity suggest an important role for Mc-cpa...

Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells

Braga, Tiago, Grujic, Mirjana, Lukinius, Agneta, Hellman, Lars, Åbrink, Magnus, Pejler, Gunnar

SG (serglycin) PGs (proteoglycans) are strongly implicated in the assembly of MC (mast cell) granules. However, this notion has mainly been on the basis of studies of MCs of the connective tissue...

Secretory Granule Proteases in Rat Mast Cells. Cloning of 10 Different Serine Proteases and a Carboxypeptidase A from Various Rat Mast Cell Populations

Lützelschwab, Claudia, Pejler, Gunnar, Aveskogh, Maria, Hellman, Lars

Two of the major rat mast cell proteases, rat mast cell protease 1 (RMCP-1) and RMCP-2, have for many years served as important phenotypic markers for studies of various aspects of mast cell (MC)...