Lars Wiklund

Cardio-cerebral and metabolic effects of methylene blue in hypertonic sodium lactate during experimental cardiopulmonary resuscitation (2007)

Miclescu, Adriana, Basu, Samar, Wiklund, Lars

BACKGROUND: Methylene blue (MB) administered with a hypertonic-hyperoncotic solution reduces the myocardial and cerebral damage due to ischaemia and reperfusion injury after experimental cardiac...

Methylene blue added to a hypertonic-hyperoncotic solution increases short-term survival in experimental cardiac arrest (2006)

Miclescu, Adriana, Basu, Samar, Wiklund, Lars

OBJECTIVE: Methylene blue (MB), a free-radical scavenger inhibiting the production and actions of nitric oxide, may counteract excessive vasodilatation induced by nitric oxide during cardiac arrest....

Evidence for Time-dependent Maximum Increase ofFree Radical Damage and Eicosanoid Formation in theBrain as Related to Duration of Cardiac Arrest andCardio-pulmonary Resuscitation (2003)

Basu, Samar, Liu, Xiaoli, Nozari, Ala, Rubertsson, Sten, Miclescu, Adriana, Wiklund, Lars

Recovery of neurological function in patients following cardiac arrest and cardiopulmonary resuscitation (CPR) is a complex event. Free radical induced oxidative stress is supposed to be involved in...

Methylene blue administration during cardio-pulmonary resuscitation and early reperfusion protects against cortical blood-brain barrier disruption

Miclescu, Adriana, Sharma, Hari Shanker, Martijn, Cécile, Wiklund, Lars

Objective: The present study was designed to study the effects of cardiac arrest and cardiopulmonary resuscitation (CPR) on blood-brain barrier (BBB) permeability and subsequent neurological injury....