Laura Santambrogio

Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis (2008)

Zsolt Tallóczy, Jose Martinez, Danielle Joset, Yonaton Ray, Attila Gácser, Sima Toussi, ...

Methamphetamine (Meth) is abused by over 35 million people worldwide. Chronic Meth abuse may be particularly devastating in individuals who engage in unprotected sex with multiple partners because it...

Abundant empty class II MHC molecules on the surface of immature dendritic cells

Santambrogio, Laura, Sato, Aaron K., Fischer, Falko R., Dorf, Martin E., Stern, Lawrence J.

A monoclonal antibody specific for the empty conformation of class II MHC molecules revealed the presence of abundant empty molecules on the surface of spleen- and bone marrow-derived dendritic cells...

Extracellular antigen processing and presentation by immature dendritic cells

Santambrogio, Laura, Sato, Aaron K., Carven, Gregory J., Belyanskaya, Svetlana L., Strominger, Jack L., Stern, Lawrence J.

In antigen presentation to CD4+ T cells, proteins are degraded to peptide fragments and loaded onto class II MHC molecules in a process involving the peptide exchange factors H-2M (murine) or HLA-DM...

Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis

Fridkis-Hareli, Masha, Santambrogio, Laura, Stern, Joel N.H., Fugger, Lars, Brosnan, Celia, Strominger, Jack L.

Copolymer 1 (Cop 1, Copaxone [Teva Marion Partners, Kansas City, Missouri, USA]), a random amino acid copolymer of tyrosine (Y), glutamic acid (E), alanine (A), and lysine (K), reduces the frequency...

Amelioration of proteolipid protein 139–151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms

Stern, Joel N. H., Illés, Zsolt, Reddy, Jayagopala, Keskin, Derin B., Sheu, Eric, Fridkis-Hareli, Masha, ...

Copolymer 1 [Cop1, glatiramer acetate, Copaxone, poly(Y,E,A,K)n] is widely used in the treatment of relapsing/remitting multiple sclerosis in which it reduces the frequency of relapses by ≈30%. In...

Modified amino acid copolymers suppress myelin basic protein 85–99-induced encephalomyelitis in humanized mice through different effects on T cells

Illés, Zsolt, Stern, Joel N. H., Reddy, Jayagopala, Waldner, Hanspeter, Mycko, Marcin P., Brosnan, Celia F., ...

A humanized mouse bearing the HLA-DR2 (DRA/DRB1*1501) protein associated with multiple sclerosis (MS) and the myelin basic protein (MBP) 85–99-specific HLA-DR2-restricted T cell receptor from an MS...

Caspases and nitric oxide broadly regulate dendritic cell maturation and surface expression of class II MHC proteins

Wong, Siew Heng, Santambrogio, Laura, Strominger, Jack L.

The passage of dendritic cells (DC) from immature to terminally differentiated antigen-presenting cells is accompanied by numerous morphological, phenotypic, and functional changes. These changes...

CD4-Specific Transgenic Expression of Human Cyclin T1 Markedly Increases Human Immunodeficiency Virus Type 1 (HIV-1) Production by CD4+ T Lymphocytes and Myeloid Cells in Mice Transgenic for a Provirus Encoding a Monocyte-Tropic HIV-1 Isolate

Sun, Jinglin, Soos, Timothy, KewalRamani, Vineet N., Osiecki, Kristin, Zheng, Jian Hua, Falkin, Laurie, ...

Human immunodeficiency virus type 1 (HIV-1)-encoded Tat provides transcriptional activation critical for efficient HIV-1 replication by interacting with cyclin T1 and recruiting P-TEFb to efficiently...

Abundant empty class II MHC molecules on the surface of immature dendritic cells

Santambrogio, Laura, Sato, Aaron K., Fischer, Falko R., Dorf, Martin E., Stern, Lawrence J.

A monoclonal antibody specific for the empty conformation of class II MHC molecules revealed the presence of abundant empty molecules on the surface of spleen- and bone marrow-derived dendritic cells...

Extracellular antigen processing and presentation by immature dendritic cells

Santambrogio, Laura, Sato, Aaron K., Carven, Gregory J., Belyanskaya, Svetlana L., Strominger, Jack L., Stern, Lawrence J.

In antigen presentation to CD4+ T cells, proteins are degraded to peptide fragments and loaded onto class II MHC molecules in a process involving the peptide exchange factors H-2M (murine) or HLA-DM...

Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis

Fridkis-Hareli, Masha, Santambrogio, Laura, Stern, Joel N.H., Fugger, Lars, Brosnan, Celia, Strominger, Jack L.

Copolymer 1 (Cop 1, Copaxone [Teva Marion Partners, Kansas City, Missouri, USA]), a random amino acid copolymer of tyrosine (Y), glutamic acid (E), alanine (A), and lysine (K), reduces the frequency...

Amelioration of proteolipid protein 139–151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms

Stern, Joel N. H., Illés, Zsolt, Reddy, Jayagopala, Keskin, Derin B., Sheu, Eric, Fridkis-Hareli, Masha, ...

Copolymer 1 [Cop1, glatiramer acetate, Copaxone, poly(Y,E,A,K)n] is widely used in the treatment of relapsing/remitting multiple sclerosis in which it reduces the frequency of relapses by ≈30%. In...

Modified amino acid copolymers suppress myelin basic protein 85–99-induced encephalomyelitis in humanized mice through different effects on T cells

Illés, Zsolt, Stern, Joel N. H., Reddy, Jayagopala, Waldner, Hanspeter, Mycko, Marcin P., Brosnan, Celia F., ...

A humanized mouse bearing the HLA-DR2 (DRA/DRB1*1501) protein associated with multiple sclerosis (MS) and the myelin basic protein (MBP) 85–99-specific HLA-DR2-restricted T cell receptor from an MS...

Caspases and nitric oxide broadly regulate dendritic cell maturation and surface expression of class II MHC proteins

Wong, Siew Heng, Santambrogio, Laura, Strominger, Jack L.

The passage of dendritic cells (DC) from immature to terminally differentiated antigen-presenting cells is accompanied by numerous morphological, phenotypic, and functional changes. These changes...

CD4-Specific Transgenic Expression of Human Cyclin T1 Markedly Increases Human Immunodeficiency Virus Type 1 (HIV-1) Production by CD4+ T Lymphocytes and Myeloid Cells in Mice Transgenic for a Provirus Encoding a Monocyte-Tropic HIV-1 Isolate

Sun, Jinglin, Soos, Timothy, KewalRamani, Vineet N., Osiecki, Kristin, Zheng, Jian Hua, Falkin, Laurie, ...

Human immunodeficiency virus type 1 (HIV-1)-encoded Tat provides transcriptional activation critical for efficient HIV-1 replication by interacting with cyclin T1 and recruiting P-TEFb to efficiently...

Induction and Suppression of an Autoimmune Disease by Oligomerized T Cell Epitopes: Enhanced in Vivo Potency of Encephalitogenic Peptides

Falk, Kirsten, Rötzschke, Olaf, Santambrogio, Laura, Dorf, Martin E., Brosnan, Celia, Strominger, Jack L.

T cell epitope peptides derived from proteolipid protein (PLP139–151) or myelin basic protein (MBP86–100) induce experimental autoimmune encephalomyelitis (EAE) in “susceptible” strains of...

Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis

Tallóczy, Zsolt, Martinez, Jose, Joset, Danielle, Ray, Yonaton, Gácser, Attila, Toussi, Sima, ...

Methamphetamine (Meth) is abused by over 35 million people worldwide. Chronic Meth abuse may be particularly devastating in individuals who engage in unprotected sex with multiple partners because it...

Immunogenecity of Modified Alkane Polymers Is Mediated through TLR1/2 Activation

Maitra, Radhashree, Clement, Cristina C., Crisi, Giovanna M., Cobelli, Neil, Santambrogio, Laura

A Monoclonal Antibody to Histoplasma capsulatum Alters the Intracellular Fate of the Fungus in Murine Macrophages▿ †

Shi, Li, Albuquerque, Priscila C., Lazar-Molnar, Eszter, Wang, Xintao, Santambrogio, Laura, Gácser, Attila, ...

Monoclonal antibodies (MAbs) to a cell surface histone on Histoplasma capsulatum modify murine infection and decrease the growth of H. capsulatum within macrophages. Without the MAbs, H. capsulatum...

Correction: Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis

Tallóczy, Zsolt, Martinez, Jose, Joset, Danielle, Ray, Yonaton, Gácser, Attila, Toussi, Sima, ...

Neuroprotection and Remyelination after Autoimmune Demyelination in Mice that Inducibly Overexpress CXCL1

Omari, Kakuri M., Lutz, Sarah E., Santambrogio, Laura, Lira, Sergio A., Raine, Cedric S.

In rodents, the chemokine CXCL1 both induces the proliferation and inhibits the migration of oligodendrocyte precursor cells. We previously reported that in multiple sclerosis, the same chemokine is...

Anthrax Lethal Toxin Triggers the Formation of a Membrane-Associated Inflammasome Complex in Murine Macrophages▿

Nour, Adel M., Yeung, Yee-Guide, Santambrogio, Laura, Boyden, Eric D., Stanley, E. Richard, Brojatsch, Jürgen

Multiple microbial components trigger the formation of an inflammasome complex that contains pathogen-specific nucleotide oligomerization and binding domain (NOD)-like receptors (NLRs), caspase-1,...