Cardiac and coronary function in the Langendorff-perfused mouse heart model (2008)
Reichelt, Melissa Elizabeth, Willems, Laura, Hack, Benjamin A., Peart, Jason Nigel John, Headrick, John Patrick
The Langendorff mouse heart model is widely employed in studies of myocardial function and responses to injury (e.g. ischaemia). Nonetheless, marked variability exists in its preparation and...
Cardiac and coronary function in the Langendorff-perfused mouse heart model (2008)
Reichelt, Melissa Elizabeth, Willems, Laura, Hack, Benjamin A., Peart, Jason Nigel John, Headrick, John Patrick
The Langendorff mouse heart model is widely employed in studies of myocardial function and responses to injury (e.g. ischaemia). Nonetheless, marked variability exists in its preparation and...
Contractile effects of adenosine, coronary flow and perfusion pressure in murine myocardium (2007)
Willems, Laura, Headrick, John Patrick
Yes
Reichelt, Melissa Elizabeth, Willems, Laura, Peart, Jason Nigel John, Ashton, Kevin John, Matherne, G. Paul, Blackburn, Michael R., ...
Yes
Reichelt, Melissa Elizabeth, Willems, Laura, Peart, Jason Nigel John, Ashton, Kevin John, Matherne, G. Paul, Blackburn, Michael R., ...
Reichelt, Melissa Elizabeth, Willems, Laura, Peart, Jason Nigel John, Ashton, Kevin John, Matherne, G. Paul, Blackburn, Michael R., ...
Ashton, Kevin John, Willems, Laura, Holmgren, Kirsty, Ferreira, Linda Anne, Headrick, John Patrick
Aged hearts exhibit reduced tolerance to ischemia-reperfusion, together with altered structure and post-ischemic remodelling. The molecular bases of such changes are unclear. Using cDNA microarrays...
Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...
OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Ashton, Kevin John, Willems, Laura, Holmgren, Kirsty, Ferreira, Linda Anne, Headrick, John Patrick
Aged hearts exhibit reduced tolerance to ischemia-reperfusion, together with altered structure and post-ischemic remodelling. The molecular bases of such changes are unclear. Using cDNA microarrays...
Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...
OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Ashton, Kevin John, Willems, Laura, Holmgren, Kirsty, Ferreira, Linda Anne, Headrick, John Patrick
Aged hearts exhibit reduced tolerance to ischemia-reperfusion, together with altered structure and post-ischemic remodelling. The molecular bases of such changes are unclear. Using cDNA microarrays...
Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...
OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Ashton, Kevin John, Willems, Laura, Holmgren, Kirsty, Ferreira, Linda Anne, Headrick, John Patrick
Aged hearts exhibit reduced tolerance to ischemia-reperfusion, together with altered structure and post-ischemic remodelling. The molecular bases of such changes are unclear. Using cDNA microarrays...
Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...
OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Willems, Laura, Reichelt, Melissa E., Molina, Jose G., Sun, Chun-Xiao, Chunn, Janci L., Ashton, Kevin J., ...
Objective Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance (2005)
Reichelt, Melissa Elizabeth, Willems, Laura, Molina, JG, Sun, CX, Noble, JC, Ashton, Kevin John, ...
Yes
Age-related changes in ischemic tolerance in male and female mouse hearts (2005)
Willems, Laura, Zatta, Amanda Jane, Holmgren, Kirsty, Ashton, Kevin John, Headrick, John Patrick
Yes
Willems, Laura, Headrick, John Patrick
1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site-...
Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance (2005)
Reichelt, Melissa Elizabeth, Willems, Laura, Molina, JG, Sun, CX, Noble, JC, Ashton, Kevin John, ...
Yes
Age-related changes in ischemic tolerance in male and female mouse hearts (2005)
Willems, Laura, Zatta, Amanda Jane, Holmgren, Kirsty, Ashton, Kevin John, Headrick, John Patrick
Yes
Willems, Laura, Headrick, John Patrick
1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site-...
Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance (2005)
Reichelt, Melissa Elizabeth, Willems, Laura, Molina, JG, Sun, CX, Noble, JC, Ashton, Kevin John, ...
Age-related changes in ischemic tolerance in male and female mouse hearts (2005)
Willems, Laura, Zatta, Amanda Jane, Holmgren, Kirsty, Ashton, Kevin John, Headrick, John Patrick
Willems, Laura, Headrick, John Patrick
1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site-...
Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance (2005)
Reichelt, Melissa Elizabeth, Willems, Laura, Molina, JG, Sun, CX, Noble, JC, Ashton, Kevin John, ...
Age-related changes in ischemic tolerance in male and female mouse hearts (2005)
Willems, Laura, Zatta, Amanda Jane, Holmgren, Kirsty, Ashton, Kevin John, Headrick, John Patrick
Willems, Laura, Headrick, John Patrick
1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site-...
Adenosine-mediated cardioprotection in the aging myocardium (2005)
Willems, Laura, Ashton, Kevin J., Headrick, John P.
With aging, it appears the heart's ability to withstand injury declines markedly. Unfortunately, the incidence of ischemic disorders increases dramatically with age. Though the genesis of the...
Age-related changes in ischaemic tolerance in mouse hearts (2004)
Willems, Laura, Headrick, John Patrick, Prof AJ Brink
No
Age-related changes in ischaemic tolerance in mouse hearts (2004)
Willems, Laura, Headrick, John Patrick
No
Effects of aging and ischemia on adenosine receptor transcription in mouse myocardium (2003)
Ashton, Kevin John, Nilsson, Ulrika, Willems, Laura, Holmgren, Kirsty, Headrick, John Patrick
Yes
Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine (2003)
Peart, Jason Nigel John, Willems, Laura, Headrick, John Patrick
Yes
Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul
The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...
Aging-related changes in myocardial purine metabolism and ischemic tolerance (2003)
Willems, Laura, Garnham, Bronwyn Gaye, Headrick, John Patrick
Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular...
Effects of aging and ischemia on adenosine receptor transcription in mouse myocardium (2003)
Ashton, Kevin John, Nilsson, Ulrika, Willems, Laura, Holmgren, Kirsty, Headrick, John Patrick
Yes
Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine (2003)
Peart, Jason Nigel John, Willems, Laura, Headrick, John Patrick
Yes
Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul
The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...
Aging-related changes in myocardial purine metabolism and ischemic tolerance (2003)
Willems, Laura, Garnham, Bronwyn Gaye, Headrick, John Patrick
Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular...
Effects of aging and ischemia on adenosine receptor transcription in mouse myocardium (2003)
Ashton, Kevin John, Nilsson, Ulrika, Willems, Laura, Holmgren, Kirsty, Headrick, John Patrick
Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine (2003)
Peart, Jason Nigel John, Willems, Laura, Headrick, John Patrick
Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul
The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...
Aging-related changes in myocardial purine metabolism and ischemic tolerance (2003)
Willems, Laura, Garnham, Bronwyn Gaye, Headrick, John Patrick
Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular...
Effects of aging and ischemia on adenosine receptor transcription in mouse myocardium (2003)
Ashton, Kevin John, Nilsson, Ulrika, Willems, Laura, Holmgren, Kirsty, Headrick, John Patrick
Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine (2003)
Peart, Jason Nigel John, Willems, Laura, Headrick, John Patrick
Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul
The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...
Aging-related changes in myocardial purine metabolism and ischemic tolerance (2003)
Willems, Laura, Garnham, Bronwyn Gaye, Headrick, John Patrick
Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular...
Zatta, Amanda Jane, Willems, Laura, Headrick, John Patrick
Objectives: To assess the impact of ischemia-reperfusion (I/R) on coronary function, and the role of endogenous adenosine in modifying post-ischemic vascular function in asanguinous hearts. Methods:...
Zatta, Amanda Jane, Willems, Laura, Headrick, John Patrick
Objectives: To assess the impact of ischemia-reperfusion (I/R) on coronary function, and the role of endogenous adenosine in modifying post-ischemic vascular function in asanguinous hearts. Methods:...
Zatta, Amanda Jane, Willems, Laura, Headrick, John Patrick
Objectives: To assess the impact of ischemia-reperfusion (I/R) on coronary function, and the role of endogenous adenosine in modifying post-ischemic vascular function in asanguinous hearts. Methods:...
Zatta, Amanda Jane, Willems, Laura, Headrick, John Patrick
Objectives: To assess the impact of ischemia-reperfusion (I/R) on coronary function, and the role of endogenous adenosine in modifying post-ischemic vascular function in asanguinous hearts. Methods:...
Flood, Amanda J, Willems, Laura, Headrick, John P
Objectives: To assess the impact of ischemia-reperfusion (I/R) on coronary function, and the role of endogenous adenosine in modifying post-ischemic vascular function in asanguinous hearts. Methods:...
Headrick, John P, Willems, Laura, Ashton, Kevin J, Holmgren, Kirsten, Peart, Jason, Matherne, G Paul
The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...