Laurence B. Peterson

Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice (2008)

Mangada, Julie A., Pearson, Todd, Brehm, Michael A., Wicker, Linda S., Peterson, Laurence B., Shultz, Leonard D., ...

OBJECTIVE: NOD mice model human type 1 diabetes and are used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. However, costimulation blockade-based...

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes (2005)

Maier, Lisa M, Smyth, Deborah J, Vella, Adrian, Payne, Felicity, Cooper, Jason D, Pask, Rebecca, ...

Abstract Background One strategy to help identify susceptibility genes for complex, multifactorial diseases is to map disease loci in a representative animal model of the disorder. The nonobese...

Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice (2004)

Gordon, Ethel J., Wicker, Linda S., Peterson, Laurence B., Serreze, David V., Markees, Thomas G., Shultz, Leonard D., ...

Costimulation blockade induces prolonged rat islet and skin xenograft survival in C57BL/6 mice. Nonobese diabetic (NOD) mice, which are used to model human autoimmune diabetes, are resistant to...

Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3 (2004)

Pearson, Todd, Weiser, Peter, Markees, Thomas G., Serreze, David V., Wicker, Linda S., Peterson, Laurence B., ...

NOD mice develop type 1 autoimmune diabetes and exhibit genetically dominant resistance to transplantation tolerance induction. These two phenotypes are genetically separable. Costimulation blockade...

Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms (2003)

Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Wicker, Linda S., Peterson, Laurence B., ...

Recent advances in islet transplantation have enabled physicians to cure type 1 autoimmune diabetes, but at the cost of lifelong immunosuppression with its attendant side effects and long-term health...

Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice (2003)

Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Wicker, Linda S., Peterson, Laurence B., ...

Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice (2003)

Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Marron, Michele P., Wicker, Linda S., ...

Curing type 1 diabetes by islet transplantation requires overcoming both allorejection and recurrent autoimmunity. This has been achieved with systemic immunosuppression, but tolerance induction...

NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction (2003)

Pearson, Todd, Markees, Thomas G., Wicker, Linda S., Serreze, David V., Peterson, Laurence B., Mordes, John P., ...

The loss of self-tolerance leading to autoimmune type 1 diabetes in the NOD mouse model involves at least 19 genetic loci. In addition to their genetic defects in self-tolerance, NOD mice resist...

Combining Mouse Congenic Strains and Microarray Gene Expression Analyses to Study a Complex Trait: The NOD Model of Type 1 Diabetes (2003)

Eaves, Iain A., Wicker, Linda S., Ghandour, Ghassan, Lyons, Paul A., Peterson, Laurence B., Todd, John A., ...

Combining Mouse Congenic Strains and Microarray Gene Expression Analyses to Study a Complex Trait: The NOD Model of Type 1 Diabetes (2002)

Eaves, Iain A., Wicker, Linda S., Ghandour, Ghassan, Lyons, Paul A., Peterson, Laurence B., Todd, John A., ...

Congenic Mapping of the Type 1 Diabetes Locus, Idd3, to a 780-kb Region of Mouse Chromosome 3: Identification of a Candidate Segment of Ancestral DNA by Haplotype Mapping (2000)

Lyons, Paul A., Armitage, Nicola, Argentina, Fabio, Denny, Paul, Hill, Natasha J., Lord, Christopher J., ...

Congenic Mapping of the Type 1 Diabetes Locus, Idd3, to a 780-kb Region of Mouse Chromosome 3: Identification of a Candidate Segment of Ancestral DNA by Haplotype Mapping

Lyons, Paul A., Armitage, Nicola, Argentina, Fabio, Denny, Paul, Hill, Natasha J., Lord, Christopher J., ...

Type 1 diabetes in the nonobese diabetic (NOD) mouse arises as a consequence of T cell-mediated destruction of the insulin-producing β cells of the pancreas. Although little is known of the events...

Effect of Hypersensitivity on Protein Uptake Across the Air-Blood Barrier of Isolated Rabbit Lungs

Braley, Janet F., Peterson, Laurence B., Dawson, Christopher A., Moore, Vernon L.

In previous studies with isolated perfused rabbit lungs, we observed that human serum albumin (HSA) and ovalbumin, introduced into the isolated lungs as an aerosol, entered the pulmonary circulation...

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

Maier, Lisa M, Smyth, Deborah J, Vella, Adrian, Payne, Felicity, Cooper, Jason D, Pask, Rebecca, ...

Congenic Mapping of the Type 1 Diabetes Locus, Idd3, to a 780-kb Region of Mouse Chromosome 3: Identification of a Candidate Segment of Ancestral DNA by Haplotype Mapping

Lyons, Paul A., Armitage, Nicola, Argentina, Fabio, Denny, Paul, Hill, Natasha J., Lord, Christopher J., ...

Type 1 diabetes in the nonobese diabetic (NOD) mouse arises as a consequence of T cell-mediated destruction of the insulin-producing β cells of the pancreas. Although little is known of the events...

Effect of Hypersensitivity on Protein Uptake Across the Air-Blood Barrier of Isolated Rabbit Lungs

Braley, Janet F., Peterson, Laurence B., Dawson, Christopher A., Moore, Vernon L.

In previous studies with isolated perfused rabbit lungs, we observed that human serum albumin (HSA) and ovalbumin, introduced into the isolated lungs as an aerosol, entered the pulmonary circulation...

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

Maier, Lisa M, Smyth, Deborah J, Vella, Adrian, Payne, Felicity, Cooper, Jason D, Pask, Rebecca, ...

NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis

Irie, Junichiro, Wu, Yuehong, Wicker, Linda S., Rainbow, Daniel, Nalesnik, Michael A., Hirsch, Raphael, ...

Primary biliary cirrhosis (PBC) is an autoimmune disease with a strong genetic component characterized by biliary ductular inflammation with eventual liver cirrhosis. The serologic hallmark of PBC is...