Laurence Lavie

Human endogenous retrovirus family HERV-K(HML-5): Status, evolution, and reconstruction of an ancient betaretrovirus in the human genome (2004)

Lavie, Laurence, Medstrand, Patrik, Schempp, Werner, Meese, Eckart, Mayer, Jens

The human genome harbors numerous distinct families of so-called human endogenous retroviruses (HERV) which are remnants of exogenous retroviruses that entered the germ line millions of years ago. We...

Synthesis and processing of tRNA-related SINE transcripts in Arabidopsis thaliana (2004)

Pélissier, Thierry, Bousquet-Antonelli, Cécile, Lavie, Laurence, Deragon, Jean-Marc

Despite the ubiquitous distribution of tRNA-related short interspersed elements (SINEs) in eukaryotic species, very little is known about the synthesis and processing of their RNAs. In this work, we...

The human L1 promoter: Variable transcription initiation sites and a major impact of upstream flanking sequence on promoter activity (2004)

Lavie, Laurence, Maldener, Esther, Brouha, Brook, Meese, Eckart U., Mayer, Jens

Human L1 elements are non-LTR retrotransposons that comprise ∼17% of the human genome. Their 5′-untranslated region (5′-UTR) serves as a promoter for L1 transcription. Now we find that...

The Evolutionary Origin and Genomic Organization of SINEs in Arabidopsis thaliana (2001)

Lenoir, Alain, Lavie, Laurence, Prieto, José-Luis, Goubely, Chantal, Cote, Jean-Charles, Pélissier, Thierry, ...

We have characterized the two families of SINE retroposons present in Arabidopsis thaliana. The origin, distribution, organization, and evolutionary history of RAthE1 and RAthE2 elements were studied...

Human Endogenous Retrovirus Family HERV-K(HML-5): Status, Evolution, and Reconstruction of an Ancient Betaretrovirus in the Human Genome†

Lavie, Laurence, Medstrand, Patrik, Schempp, Werner, Meese, Eckart, Mayer, Jens

The human genome harbors numerous distinct families of so-called human endogenous retroviruses (HERV) which are remnants of exogenous retroviruses that entered the germ line millions of years ago. We...

Synthesis and processing of tRNA-related SINE transcripts in Arabidopsis thaliana

Pélissier, Thierry, Bousquet-Antonelli, Cécile, Lavie, Laurence, Deragon, Jean-Marc

Despite the ubiquitous distribution of tRNA-related short interspersed elements (SINEs) in eukaryotic species, very little is known about the synthesis and processing of their RNAs. In this work, we...

The human L1 promoter: Variable transcription initiation sites and a major impact of upstream flanking sequence on promoter activity

Lavie, Laurence, Maldener, Esther, Brouha, Brook, Meese, Eckart U., Mayer, Jens

Human L1 elements are non-LTR retrotransposons that comprise ∼17% of the human genome. Their 5′-untranslated region (5′-UTR) serves as a promoter for L1 transcription. Now we find that...

CpG Methylation Directly Regulates Transcriptional Activity of the Human Endogenous Retrovirus Family HERV-K(HML-2)

Lavie, Laurence, Kitova, Milena, Maldener, Esther, Meese, Eckart, Mayer, Jens

A significant proportion of the human genome consists of stably inherited retroviral sequences. Most human endogenous retroviruses (HERVs) became defective over time. The HERV-K(HML-2) family is...

Human Endogenous Retrovirus Family HERV-K(HML-5): Status, Evolution, and Reconstruction of an Ancient Betaretrovirus in the Human Genome†

Lavie, Laurence, Medstrand, Patrik, Schempp, Werner, Meese, Eckart, Mayer, Jens

The human genome harbors numerous distinct families of so-called human endogenous retroviruses (HERV) which are remnants of exogenous retroviruses that entered the germ line millions of years ago. We...

Synthesis and processing of tRNA-related SINE transcripts in Arabidopsis thaliana

Pélissier, Thierry, Bousquet-Antonelli, Cécile, Lavie, Laurence, Deragon, Jean-Marc

Despite the ubiquitous distribution of tRNA-related short interspersed elements (SINEs) in eukaryotic species, very little is known about the synthesis and processing of their RNAs. In this work, we...

The human L1 promoter: Variable transcription initiation sites and a major impact of upstream flanking sequence on promoter activity

Lavie, Laurence, Maldener, Esther, Brouha, Brook, Meese, Eckart U., Mayer, Jens

Human L1 elements are non-LTR retrotransposons that comprise ∼17% of the human genome. Their 5′-untranslated region (5′-UTR) serves as a promoter for L1 transcription. Now we find that...

CpG Methylation Directly Regulates Transcriptional Activity of the Human Endogenous Retrovirus Family HERV-K(HML-2)

Lavie, Laurence, Kitova, Milena, Maldener, Esther, Meese, Eckart, Mayer, Jens

A significant proportion of the human genome consists of stably inherited retroviral sequences. Most human endogenous retroviruses (HERVs) became defective over time. The HERV-K(HML-2) family is...