Akué-Gédu, Rufine, Debiton, Eric, Ferandin, Yoan, Meijer, Laurent, Prudhomme, Michelle, Anizon, Fabrice, ...
The synthesis of new meridianin derivatives substituted at the C-5 position of the 2-aminopyrimidine ring by various aryl groups and substituted or not by a methyl group on the indole nitrogen is...
Akué-Gédu, Rufine, Debiton, Eric, Ferandin, Yoan, Meijer, Laurent, Prudhomme, Michelle, Anizon, Fabrice, ...
The synthesis of new meridianin derivatives substituted at the C-5 position of the 2-aminopyrimidine ring by various aryl groups and substituted or not by a methyl group on the indole nitrogen is...
Anticancer Alkaloid Lamellarins Inhibit Protein Kinases (2008)
Dianne Baunbæk, Nolwenn Trinkler, Yoan Ferandin, Olivier Lozach, Poonsakdi Ploypradith, Somsak Rucirawat, ...
Lamellarins, a family of hexacyclic pyrrole alkaloids originally isolated from marine invertebrates, display promising anti-tumor activity. They induce apoptotic cell death through multi-target...
Bettayeb, Karima, Tirado, Oscar M., Marionneau-Lambot, Severine, Ferandin, Yoan, Lozach, Olivier, Morris, Jonathan Charles, ...
© 2007 American Association for Cancer Research
Bettayeb, Karima, Tirado, Oscar M., Marionneau-Lambot, Severine, Ferandin, Yoan, Lozach, Olivier, Morris, Jonathan Charles, ...
© 2007 American Association for Cancer Research
Characterization of two T. gondii CK1 isoforms (2005)
R. G., Donald, T., Zhong, Meijer, Laurent, Liberator, P.A.
Previous affinity chromatography experiments have described the unexpected binding of an isoform of casein kinase I (CK1) from Leishmania mexicana, Trypanosoma cruzi, Plasmodium falciparum and...
Grant, Karen M., Dunion, Morag H., Yardley, Vanessa, Skaltsounis , Alexios-Leandros, Marko, Doris, Eisenbrand, Gerhard, ...
The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of...
Malgrange, Brigitte, Knockaert, Marie, Belachew, Shibeshih, Nguyen, Laurent, Moonen, Gustave, Meijer, Laurent, ...
In the embryonic day 19 organs of Corti, we showed that roscovitine, a chemical inhibitor of cyclin-dependent kinases (CDKs), significantly increased the number of hair cells (HCs) and corresponding...
Knockaert, Marie, Wieking, Karen, Schmitt, Sophie, Leost, Maryse, Grant, Karen M., Mottram, Jeremy C., ...
Numerous inhibitors of cyclin-dependent kinases and glycogen synthase kinase-3 (GSK-3) are being developed in view of their potential applications against cancers and neurodegenerative disorders....
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
Knockaert, Marie, Gray, N., Damiens, E., Grellier, P., Grant, Karen M., ...
Background: Chemical inhibitors of cyclin-dependent kinases (CDKs) have great therapeutic potential against various proliferative and neurodegenerative disorders. Olomoucine, a 2,6,9-trisubstituted...
Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors (1998)
Kim, Sung-Hou, Meijer, Laurent, LeClerc, Sophie, Barnes, Georjana, Morgan, David O., Espinoza, F. Hernan, ...
Selective protein kinase inhibitors were developed on the basis of the unexpected binding mode of 2,6,9-trisubstituted purines to the adenosine triphosphate-binding site of the human cyclin-dependent...
Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors (1998)
Lockhart, David J., Kim, Sung-Hou, Meijer, Laurent, LeClerc, Sophie, Barnes, Georjana, Morgan, David O., ...
Selective protein kinase inhibitors were developed on the basis of the unexpected binding mode of 2,6,9-trisubstituted purines to the adenosine triphosphate-binding site of the human cyclin-dependent...
Th. 3ème cycle : Biol. du Dévelop. et de la Reprod. : Lille 1 : 1978 ; 701.
Ouarzane-Amara, Meryem, Franetich, Jean-François, Mazier, Dominique, Pettit, George R., Meijer, Laurent, Doerig, Christian, ...
The antiparasitic effect of a collection of compounds with antimitotic activity has been tested on a mammalian cell line infected with Encephalitozoon intestinalis, a microsporidian causing...
Wang, Dai, De La Fuente, Cynthia, Deng, Longwen, Wang, Lai, Zilberman, Irene, Eadie, Carolyn, ...
Cyclin-dependent kinases (cdk's) have recently been suggested to regulate human immunodeficiency virus type 1 (HIV-1) transcription. Previously, we have shown that expression of one cdk inhibitor,...
Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
Schang, Luis M., Bantly, Andrew, Knockaert, Marie, Shaheen, Farida, Meijer, Laurent, Malim, Michael H., ...
Pharmacological cyclin-dependent kinase (cdk) inhibitors (PCIs) block replication of several viruses, including herpes simplex virus type 1 (HSV-1) and human immunodeficiency virus type 1 (HIV-1)....
Grant, Karen M., Dunion, Morag H., Yardley, Vanessa, Skaltsounis, Alexios-Leandros, Marko, Doris, Eisenbrand, Gerhard, ...
The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of...
Degradation of Hof1 by SCFGrr1 is important for actomyosin contraction during cytokinesis in yeast
Blondel, Marc, Bach, Stéphane, Bamps, Sophie, Dobbelaere, Jeroen, Wiget, Philippe, Longaretti, Céline, ...
SCF-type (SCF: Skp1–Cullin–F-box protein complex) E3 ligases regulate ubiquitin-dependent degradation of many cell cycle regulators, mainly at the G1/S transition. Here, we show that SCFGrr1...
Yang, Hua, Zheng, Shu, Meijer, Laurent, Li, Shi-min, Leclerc, Sophie, Yu, Lin-lin, ...
Objective: To screen and evaluate the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 phosphatase. Methods: The affinity chromatography purified...
Ouarzane-Amara, Meryem, Franetich, Jean-François, Mazier, Dominique, Pettit, George R., Meijer, Laurent, Doerig, Christian, ...
The antiparasitic effect of a collection of compounds with antimitotic activity has been tested on a mammalian cell line infected with Encephalitozoon intestinalis, a microsporidian causing...
Wang, Dai, De La Fuente, Cynthia, Deng, Longwen, Wang, Lai, Zilberman, Irene, Eadie, Carolyn, ...
Cyclin-dependent kinases (cdk's) have recently been suggested to regulate human immunodeficiency virus type 1 (HIV-1) transcription. Previously, we have shown that expression of one cdk inhibitor,...
Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity
Biernat, Jacek, Wu, Yong-Zhong, Timm, Thomas, Zheng-Fischhöfer, Qingyi, Mandelkow, Eckhard, Meijer, Laurent, ...
Protein kinases of the microtubule affinity-regulating kinase (MARK) family were originally discovered because of their ability to phosphorylate certain sites in tau protein (KXGS motifs in the...
Schang, Luis M., Bantly, Andrew, Knockaert, Marie, Shaheen, Farida, Meijer, Laurent, Malim, Michael H., ...
Pharmacological cyclin-dependent kinase (cdk) inhibitors (PCIs) block replication of several viruses, including herpes simplex virus type 1 (HSV-1) and human immunodeficiency virus type 1 (HIV-1)....
Grant, Karen M., Dunion, Morag H., Yardley, Vanessa, Skaltsounis, Alexios-Leandros, Marko, Doris, Eisenbrand, Gerhard, ...
The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of...
Degradation of Hof1 by SCFGrr1 is important for actomyosin contraction during cytokinesis in yeast
Blondel, Marc, Bach, Stéphane, Bamps, Sophie, Dobbelaere, Jeroen, Wiget, Philippe, Longaretti, Céline, ...
SCF-type (SCF: Skp1–Cullin–F-box protein complex) E3 ligases regulate ubiquitin-dependent degradation of many cell cycle regulators, mainly at the G1/S transition. Here, we show that SCFGrr1...
Yang, Hua, Zheng, Shu, Meijer, Laurent, Li, Shi-min, Leclerc, Sophie, Yu, Lin-lin, ...
Objective: To screen and evaluate the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 phosphatase. Methods: The affinity chromatography purified...
Anticancer Alkaloid Lamellarins Inhibit Protein Kinases
Baunbæk, Dianne, Trinkler, Nolwenn, Ferandin, Yoan, Lozach, Olivier, Ploypradith, Poonsakdi, Rucirawat, Somsak, ...
Lamellarins, a family of hexacyclic pyrrole alkaloids originally isolated from marine invertebrates, display promising anti-tumor activity. They induce apoptotic cell death through multi-target...
Xingi, Evangelia, Smirlis, Despina, Myrianthopoulos, Vassilios, Prokopios, Magiatis, Grant, Karen, Meijer, Laurent, ...
Indirubins known to target mammalian cyclin-dependent kinases (CDKs) and glycogen synthase kinase (GSK-3) were tested for their antileishmanial activity. 6-Br-indirubin-3'-oxime (6-BIO),...