Lawrence R. Gahan

Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle (2008)

Schenk, Gerhard, Elliott, Tristan W, Leung, Eleanor, Carrington, Lyle E, Mitić, Nataša, Gahan, Lawrence R, ...

Abstract Background Purple acid phosphatases belong to the family of binuclear metallohydrolases and are involved in a multitude of biological functions, ranging from bacterial killing and bone...

Inhibition studies of purple acid phosphatases: implications for the catalytic mechanism (2006)

Elliott,Tristan W., Mitic,Nataša, Gahan,Lawrence R., Guddat,Luke W., Schenk,Gerhard

Purple acid phosphatases (PAPs) belong to the family of binuclear metallohydrolases and catalyse the hydrolysis of a large group of phosphoester substrates at acidic pH. Despite structural...

Structural Studies of Copper(II)-Amine Terminated Dendrimer Complexes by EXAFS (2004)

M. Linh Tran, Lawrence R. Gahan, Ian R. Gentle

Previously it had been reported that copper(II) formed complexes with the PAMAM dendrimer only at the surface. Through a detailed analysis of the structure using EXAFS we showed that the metal ion...

Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solvent (2004)

Van Den Brenk, Anna L., Tyndall, Joel D. A., Cusack, Rodney M., Jones, Alun, Fairlie, David P., Gahan, Lawrence R., ...

Patellamide D (patH(4)) is a cyclic octapeptide isolated from the ascidian Lissoclinum patella. The peptide possesses a 24-azacrown-8 macrocyclic structure containing two oxazoline and two thiazole...

Structural Studies of Copper(II)-Amine Terminated Dendrimer Complexes by EXAFS (2004)

M. Linh Tran, Lawrence R. Gahan, Ian R. Gentle

Previously it had been reported that copper(II) formed complexes with the PAMAM dendrimer only at the surface. Through a detailed analysis of the structure using EXAFS we showed that the metal ion...

Structural studies of copper(II)-amine terminated dendrimer complexes by EXAFS (2004)

Tran, M. Linh, Gahan, Lawrence R., Gentle, Ian R.

The three-dimensional branched nature of dendritic macromolecules provides many potential sites per molecule for the complexation of metal ions. Therefore, dendrimers may act as hosts for metals with...

Synthesis, characterization and DFT studies of the cobalt(III) complex of a tetrapodal pentadentate N4S donor ligand (2004)

Sharrad, Clint A., Cavigliasso, Germán E., Stranger, Robert, Gahan, Lawrence R.

The synthesis of the pentadentate ligand 2,6-bis(3,3-dimethyl-2,4-dioxocyclohexanyl)-4-thiaheptane (N(4)Samp) is described. The synthetic pathway involves the coupling of two...

Embracing ligands. A synthetic strategy towards new nitrogen-thioether multidentate ligands and characterization of the cobalt(III) complexes (2003)

Sharrad, Clint A., Luthi, Stefan R., Gahan, Lawrence R.

The synthesis of the hexadentate ligand 2,2,9,9-tetra(methyleneamine)-4,7-dithiadecane (EtN(4)S(2)amp) is reported. The ligand is of a type in which bifurcations of the chain occur at atoms other...

Crystal and molecular structure of the tetrameric cluster cadmium complex formed from 1,4,7,10-tetraoxa-13-azacyclopentadecane-13-acetic acid (1993)

Byriel, Karl A., Gahan, Lawrence R., Kennard, Colin H.L., Latten, Josef L., Healy, Peter Conrad

Reaction of cadmium carbonate with 1,4,7,10-tetraoxa-13 azacyclopentadecane-l3-acetiacc id (HL~)in warm aqueous solution results in the isolation of crystals of the tetrarneric cluster [ ~ d 4 ( ~...

Crystal and molecular structure of the tetrameric cluster cadmium complex formed from 1,4,7,10-tetraoxa-13-azacyclopentadecane-13-acetic acid (1993)

Byriel, Karl A., Gahan, Lawrence R., Kennard, Colin H.L., Latten, Josef L., Healy, Peter Conrad

Reaction of cadmium carbonate with 1,4,7,10-tetraoxa-13 azacyclopentadecane-l3-acetiacc id (HL~)in warm aqueous solution results in the isolation of crystals of the tetrarneric cluster [ ~ d 4 ( ~...

Phosphate forms an unusual tripodal complex with the Fe–Mn center of sweet potato purple acid phosphatase

Schenk, Gerhard, Gahan, Lawrence R., Carrington, Lyle E., Mitić, Nataša, Valizadeh, Mohsen, Hamilton, Susan E., ...

Purple acid phosphatases (PAPs) are a family of binuclear metalloenzymes that catalyze the hydrolysis of phosphoric acid esters and anhydrides. A PAP in sweet potato has a unique, strongly...

Phosphate forms an unusual tripodal complex with the Fe–Mn center of sweet potato purple acid phosphatase

Schenk, Gerhard, Gahan, Lawrence R., Carrington, Lyle E., Mitić, Nataša, Valizadeh, Mohsen, Hamilton, Susan E., ...

Purple acid phosphatases (PAPs) are a family of binuclear metalloenzymes that catalyze the hydrolysis of phosphoric acid esters and anhydrides. A PAP in sweet potato has a unique, strongly...