Leander Grode

Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis (2006)

Rachman, Helmy, Strong, Michael, Ulrichs, Timo, Grode, Leander, Schuchhardt, Johannes, Mollenkopf, Hans J., ...

Cationic microparticles consisting of poly(lactide-co-glycolide) and polyethylenimine as carriers systems for parental DNA vaccination (2005)

Oster, Christine G., Kim, Nayoung, Grode, Leander, Barbu-Tudoran, Lucian, Schaper, Andreas K., Kaufmann, Stefan H. E., ...

Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guerin mutants that secrete listeriolysin (2005)

Grode, Leander, Seiler, Peter, Baumann, Sven, Hess, Jurgen, Brinkmann, Volker, Nasser Eddine, Ali, ...

Evaluation of vaccines in the EU TB Vaccine Cluster using a guinea pig aerosol infection model of tuberculosis. (2005)

Williams, Ann, Hatch, Graham J., Clark, Simon O., Gooch, Karen E., Hatch, Kim A., Hall, Graham A., ...

Comparative analysis of different vaccine constructs expressing defined antigens from Mycobacterium tuberculosis (2004)

Doherty,T. Mark, Olsen,Anja W., Weischenfeldt,Joachim, Huygen,Kris, D'Souza,Sushila, Kondratieva,Tatiana K., ...

BACKGROUND: Studies of different vaccine constructs have demonstrated variable efficacy against Mycobacterium tuberculosis in animal models. Despite the fact that these vaccines have used one or...

Application of mycobacterial proteomics to vaccine design: Improved protection by Mycobacterium bovis BCG prime-Rv3407 DNA boost vaccination against tuberculosis (2004)

Mollenkopf,Hans J., Grode,Leander, Mattow,Jens, Stein,Maik, Mann,Peggy, Knapp,Bernhard, ...

Information from comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guérin (BCG) principally allows prediction of potential vaccine candidates....

Enhanced protective efficacy of a tuberculosis DNA vaccine by adsorption onto cationic PLG microparticles (2004)

Mollenkopf,Hans-Joachim, Dietrich,Guido, Fensterle,Joachim, Grode,Leander, Diehl,Klaus-Dieter, Knapp,B, ...

Immunization with plasmid DNA vectors represents a promising new approach to vaccination. It has been shown to elicit humoral and cellular immunity and protection in various infection models. Here,...

Application of mycobacterial proteomics to vaccine design: Improved protection by Mycobacterium bovis BCG prime-Rv3407 DNA boost vaccination against tuberculosis (2004)

Mollenkopf, Hans J., Grode, Leander, Mattow, Jens, Stein, Maik, Mann, Peggy, Knapp, Bernhard, ...

Comparative analysis of different vaccine constructs expressing defined antigens from Mycobacterium tuberculosis (2004)

Doherty, T. Mark, Olsen, Anja W., Weischenfeldt, Joachim, Huygen, Kris, D'Souza, Sushila, Kondratieva, Tatiana K., ...

Enhanced protective efficacy of a tuberculosis DNA vaccine by adsorption onto cationic PLG microparticles (2004)

Mollenkopf, Hans J., Dietrich, Guido, Fensterle, Joachim, Grode, Leander, Diehl, Klaus-Dieter, Knapp, B, ...

Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses (2003)

Aichele,Peter, Zinke,Jana, Grode,Leander, Schwendener,Reto A., Kaufmann,Stefan H. E., Seiler,Peter

Rapid removal of pathogens from the circulation by secondary lymphoid organs is prerequisite for successful control of infection. Blood-borne Ags are trapped mainly in the splenic marginal zone. To...

Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses (2003)

Aichele, Peter, Zinke, Jana, Grode, Leander, Schwendener, Reto A., Kaufmann, Stefan H. E., Seiler, Peter

Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimuriumi (2002)

Koebernick,Heidrun, Grode,Leander, David,John R., Rohde,Wolfgang, Rolph,Michael S., Mittrucker,Hans-Willi, ...

The cytokine macrophage migration inhibitory factor (MIF) exerts a multitude of biological functions. Notably, it induces inflammation at the interface between the immune system and the...

Cell-mediated immunity induced by recombinant Mycobacterium bovis Bacille Calmette-Guerin strains against an intracellular bacterial pathogen: Importance of antigen secretion or membrane-targeted antigen display as lipoprotein for vaccine efficacy (2002)

Grode,Leander, Kursar,Mischo, Fensterle,Joachim, Kaufmann,Stefan H. E., Hess,Jurgen

Live recombinant vaccines expressing defined pathogen-derived Ags represent powerful candidates for future vaccination strategies. In this study, we report on the differential induction of protective...

Mycobacterial proteomes (2002)

Mollenkopf,Hans J., Mattow,Jens, Schaible,Ulrich E., Grode,Leander, Kaufmann,Stefan H. E., Jungblut,Peter R.

Cell-mediated immunity induced by recombinant Mycobacterium bovis Bacille Calmette-Guerin strains against an intracellular bacterial pathogen: Importance of antigen secretion or membrane-targeted antigen display as lipoprotein for vaccine efficacy (2002)

Grode, Leander, Kursar, Mischo, Fensterle, Joachim, Kaufmann, Stefan H. E., Hess, Jurgen

Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimuriumi (2002)

Koebernick, Heidrun, Grode, Leander, David, John R., Rohde, Wolfgang, Rolph, Michael S., Mittrücker, Hans-Willi, ...

Mycobacterial proteomes (2002)

Mollenkopf, Hans J., Mattow, Jens, Schaible, Ulrich E., Grode, Leander, Kaufmann, Stefan H. E., Jungblut, Peter R.

Limited Mycobacterial Infection of the Liver as a Consequence of Its Microanatomical Structure Causing Restriction of Mycobacterial Growth to Professional Phagocytes

Seiler, Peter, Schwendener, Reto A., Bandermann, Silke, Brinkmann, Volker, Grode, Leander, Kaufmann, Stefan H. E., ...

Among sites of extrapulmonary growth of Mycobacterium tuberculosis, the liver is the least infected. Our data suggest that this is due to the complete restriction of mycobacterial growth to liver...

Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium

Koebernick, Heidrun, Grode, Leander, David, John R., Rohde, Wolfgang, Rolph, Michael S., Mittrücker, Hans-Willi, ...

The cytokine macrophage migration inhibitory factor (MIF) exerts a multitude of biological functions. Notably, it induces inflammation at the interface between the immune system and the...

Application of Mycobacterial Proteomics to Vaccine Design: Improved Protection by Mycobacterium bovis BCG Prime-Rv3407 DNA Boost Vaccination against Tuberculosis

Mollenkopf, Hans Joachim, Grode, Leander, Mattow, Jens, Stein, Maik, Mann, Peggy, Knapp, Bernhard, ...

Information from comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guérin (BCG) principally allows prediction of potential vaccine candidates....

Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin

Grode, Leander, Seiler, Peter, Baumann, Sven, Hess, Jürgen, Brinkmann, Volker, Eddine, Ali Nasser, ...

The tuberculosis vaccine Mycobacterium bovis bacille Calmette-Guérin (BCG) was equipped with the membrane-perforating listeriolysin (Hly) of Listeria monocytogenes, which was shown to improve...

Unique Transcriptome Signature of Mycobacterium tuberculosis in Pulmonary Tuberculosis†

Rachman, Helmy, Strong, Michael, Ulrichs, Timo, Grode, Leander, Schuchhardt, Johannes, Mollenkopf, Hans, ...

Although tuberculosis remains a substantial global threat, the mechanisms that enable mycobacterial persistence and replication within the human host are ill defined. This study represents the first...

Limited Mycobacterial Infection of the Liver as a Consequence of Its Microanatomical Structure Causing Restriction of Mycobacterial Growth to Professional Phagocytes

Seiler, Peter, Schwendener, Reto A., Bandermann, Silke, Brinkmann, Volker, Grode, Leander, Kaufmann, Stefan H. E., ...

Among sites of extrapulmonary growth of Mycobacterium tuberculosis, the liver is the least infected. Our data suggest that this is due to the complete restriction of mycobacterial growth to liver...

Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium

Koebernick, Heidrun, Grode, Leander, David, John R., Rohde, Wolfgang, Rolph, Michael S., Mittrücker, Hans-Willi, ...

The cytokine macrophage migration inhibitory factor (MIF) exerts a multitude of biological functions. Notably, it induces inflammation at the interface between the immune system and the...

Application of Mycobacterial Proteomics to Vaccine Design: Improved Protection by Mycobacterium bovis BCG Prime-Rv3407 DNA Boost Vaccination against Tuberculosis

Mollenkopf, Hans Joachim, Grode, Leander, Mattow, Jens, Stein, Maik, Mann, Peggy, Knapp, Bernhard, ...

Information from comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette-Guérin (BCG) principally allows prediction of potential vaccine candidates....

Increased vaccine efficacy against tuberculosis of recombinant Mycobacterium bovis bacille Calmette-Guérin mutants that secrete listeriolysin

Grode, Leander, Seiler, Peter, Baumann, Sven, Hess, Jürgen, Brinkmann, Volker, Eddine, Ali Nasser, ...

The tuberculosis vaccine Mycobacterium bovis bacille Calmette-Guérin (BCG) was equipped with the membrane-perforating listeriolysin (Hly) of Listeria monocytogenes, which was shown to improve...

Unique Transcriptome Signature of Mycobacterium tuberculosis in Pulmonary Tuberculosis†

Rachman, Helmy, Strong, Michael, Ulrichs, Timo, Grode, Leander, Schuchhardt, Johannes, Mollenkopf, Hans, ...

Although tuberculosis remains a substantial global threat, the mechanisms that enable mycobacterial persistence and replication within the human host are ill defined. This study represents the first...