Liu, Jie, Nealon, Julie G., Weinstein, Lee S.
Pseudohypoparathyroidism type IB (PHPIB) is associated with abnormal imprinting of GNAS, the gene encoding the heterotrimeric G protein Gsα and other alternative products. The gene contains three...
Sakamoto, Akio, Liu, Jie, Greene, Andrew, Chen, Min, Weinstein, Lee S.
The G protein Gsα is imprinted in a tissue-specific manner, being primarily expressed from the maternal allele in some tissues, such as renal proximal tubules. The Gsα promoter is unmethylated, but...
Liu, Jie, Nealon, Julie G., Weinstein, Lee S.
Pseudohypoparathyroidism type IB (PHPIB) is associated with abnormal imprinting of GNAS, the gene encoding the heterotrimeric G protein Gsα and other alternative products. The gene contains three...
Sakamoto, Akio, Liu, Jie, Greene, Andrew, Chen, Min, Weinstein, Lee S.
The G protein Gsα is imprinted in a tissue-specific manner, being primarily expressed from the maternal allele in some tissues, such as renal proximal tubules. The Gsα promoter is unmethylated, but...
Sakamoto, Akio, Liu, Jie, Greene, Andrew, Chen, Min, Weinstein, Lee S.
The G protein Gsα is imprinted in a tissue-specific manner, being primarily expressed from the maternal allele in some tissues, such as renal proximal tubules. The Gsα promoter is unmethylated, but...
Liu, Jie, Nealon, Julie G., Weinstein, Lee S.
Pseudohypoparathyroidism type IB (PHPIB) is associated with abnormal imprinting of GNAS, the gene encoding the heterotrimeric G protein Gsα and other alternative products. The gene contains three...
Identification and localization of G protein subunits in human spermatozoa (1999)
Merlet, Françoise, Weinstein, Lee S., Goldsmith, Paul K., Rarick, Tom, Hall, Jerry L., Bisson, Jean-Pierre, ...
Antibodies to α and β subunits of guanine nucleotide regulatory proteins (G proteins) were used to identify which G proteins are present in mature human spermatozoa and to determine their...
Yu, Shuhua, Yu, Dawen, Hainline, Bryan E., Brener, Jacob L., Wilson, Kathryn, Wilson, Louise C., ...
Warner, Dennis R., Weinstein, Lee S.
It has been reported that substitution of Arg258, a residue within the GTPase domain of the heterotrimeric guanine nucleotide binding protein (G protein) α-subunit (αs), to alanine (αs-R258A)...
Yu, Shuhua, Yu, Dawen, Lee, Eric, Eckhaus, Michael, Lee, Randy, Corria, Zakia, ...
Albright hereditary osteodystrophy (AHO), an autosomal dominant disorder characterized by short stature, obesity, and skeletal defects, is associated with heterozygous inactivating mutations of...
Identification of a Methylation Imprint Mark within the Mouse Gnas Locus
Liu, Jie, Yu, Shuhua, Litman, Deborah, Chen, Weiping, Weinstein, Lee S.
The imprinted mouse gene Gnas produces the G protein α-subunit GSα and several other gene products by using alternative promoters and first exons. GSα is maternally expressed in some tissues and...
Yu, Shuhua, Gavrilova, Oksana, Chen, Hui, Lee, Randy, Liu, Jie, Pacak, Karel, ...
Heterozygous disruption of Gnas, the gene encoding the stimulatory G-protein α subunit (Gsα), leads to distinct phenotypes depending on whether the maternal (m–/+) or paternal (+/p–) allele is...
A GNAS1 imprinting defect in pseudohypoparathyroidism type IB
Liu, Jie, Litman, Deborah, Rosenberg, Marjorie J., Yu, Shuhua, Biesecker, Leslie G., Weinstein, Lee S.
Pseudohypoparathyroidism type IB (PHPIB) is characterized by renal resistance to parathyroid hormone (PTH) and the absence of other endocrine or physical abnormalities. Familial PHPIB has been mapped...
Bastepe, Murat, Weinstein, Lee S., Ogata, Naoshi, Kawaguchi, Hiroshi, Jüppner, Harald, Kronenberg, Henry M., ...
Stimulatory heterotrimeric G protein (Gs) transduces signals from various cell-surface receptors to adenylyl cyclases, which generate cAMP. The α subunit of Gs (Gsα) is encoded by GNAS (Gnas in...
Liu, Jie, Chen, Min, Deng, Chuxia, Bourc'his, Déborah, Nealon, Julie G., Erlichman, Beth, ...
Gnas is a complex gene with multiple imprinted promoters. The upstream Nesp and Nespas/Gnasxl promoters are paternally and maternally methylated, respectively. The downstream promoter for the...
Alternative Gnas gene products have opposite effects on glucose and lipid metabolism
Chen, Min, Gavrilova, Oksana, Liu, Jie, Xie, Tao, Deng, Chuxia, Nguyen, Annie T., ...
Gnas is an imprinted gene with multiple gene products resulting from alternative splicing of different first exons onto a common exon 2. These products include stimulatory G protein α-subunit...
Chen, Min, Gavrilova, Oksana, Zhao, Wei-Qin, Nguyen, Annie, Lorenzo, Javier, Shen, Laura, ...
The G protein Gsα is essential for hormone-stimulated cAMP generation and is an important metabolic regulator. We investigated the role of liver Gs-signaling pathways by developing mice with...
Warner, Dennis R., Weinstein, Lee S.
It has been reported that substitution of Arg258, a residue within the GTPase domain of the heterotrimeric guanine nucleotide binding protein (G protein) α-subunit (αs), to alanine (αs-R258A)...
Yu, Shuhua, Yu, Dawen, Lee, Eric, Eckhaus, Michael, Lee, Randy, Corria, Zakia, ...
Albright hereditary osteodystrophy (AHO), an autosomal dominant disorder characterized by short stature, obesity, and skeletal defects, is associated with heterozygous inactivating mutations of...
Identification of a Methylation Imprint Mark within the Mouse Gnas Locus
Liu, Jie, Yu, Shuhua, Litman, Deborah, Chen, Weiping, Weinstein, Lee S.
The imprinted mouse gene Gnas produces the G protein α-subunit GSα and several other gene products by using alternative promoters and first exons. GSα is maternally expressed in some tissues and...
Yu, Shuhua, Gavrilova, Oksana, Chen, Hui, Lee, Randy, Liu, Jie, Pacak, Karel, ...
Heterozygous disruption of Gnas, the gene encoding the stimulatory G-protein α subunit (Gsα), leads to distinct phenotypes depending on whether the maternal (m–/+) or paternal (+/p–) allele is...
A GNAS1 imprinting defect in pseudohypoparathyroidism type IB
Liu, Jie, Litman, Deborah, Rosenberg, Marjorie J., Yu, Shuhua, Biesecker, Leslie G., Weinstein, Lee S.
Pseudohypoparathyroidism type IB (PHPIB) is characterized by renal resistance to parathyroid hormone (PTH) and the absence of other endocrine or physical abnormalities. Familial PHPIB has been mapped...
Bastepe, Murat, Weinstein, Lee S., Ogata, Naoshi, Kawaguchi, Hiroshi, Jüppner, Harald, Kronenberg, Henry M., ...
Stimulatory heterotrimeric G protein (Gs) transduces signals from various cell-surface receptors to adenylyl cyclases, which generate cAMP. The α subunit of Gs (Gsα) is encoded by GNAS (Gnas in...
Liu, Jie, Chen, Min, Deng, Chuxia, Bourc'his, Déborah, Nealon, Julie G., Erlichman, Beth, ...
Gnas is a complex gene with multiple imprinted promoters. The upstream Nesp and Nespas/Gnasxl promoters are paternally and maternally methylated, respectively. The downstream promoter for the...
Alternative Gnas gene products have opposite effects on glucose and lipid metabolism
Chen, Min, Gavrilova, Oksana, Liu, Jie, Xie, Tao, Deng, Chuxia, Nguyen, Annie T., ...
Gnas is an imprinted gene with multiple gene products resulting from alternative splicing of different first exons onto a common exon 2. These products include stimulatory G protein α-subunit...
Chen, Min, Gavrilova, Oksana, Zhao, Wei-Qin, Nguyen, Annie, Lorenzo, Javier, Shen, Laura, ...
The G protein Gsα is essential for hormone-stimulated cAMP generation and is an important metabolic regulator. We investigated the role of liver Gs-signaling pathways by developing mice with...
Xie, Tao, Chen, Min, Zhang, Qing-Hong, Ma, Zheng, Weinstein, Lee S.
The G protein α-subunit Gsα is required for hormone-stimulated cAMP generation. In pancreatic β cells, Gsα mediates the signaling of glucagon-like peptide 1 and other incretin hormones, which are...
Osteoblastic regulation of B lymphopoiesis is mediated by Gsα-dependent signaling pathways
Wu, Joy Y., Purton, Louise E., Rodda, Stephen J., Chen, Min, Weinstein, Lee S., McMahon, Andrew P., ...
Osteoblasts play an increasingly recognized role in supporting hematopoietic development and recently have been implicated in the regulation of B lymphopoiesis. Here we demonstrate that the...
Xie, Tao, Chen, Min, Gavrilova, Oksana, Lai, Edwin W., Liu, Jie, Weinstein, Lee S.
The G protein α-subunit Gsα mediates receptor-stimulated cAMP production and is imprinted with reduced expression from the paternal allele in specific tissues. Disruption of the Gsα maternal (but...