Stowell, Nicole C, Seideman, Jonathan, Raymond, Holly A, Smalley, Karen A, Lamb, Roberta J, Egenolf, Devon D, ...
Abstract Background The immune mechanisms associated with infection-induced disease exacerbations in asthma and COPD are not fully understood. Toll-like receptor (TLR) 3 has an important role in...
Tirapu, Iñigo, Giquel, Benoit, Alexopoulou, Lena, Uematsu, Satoshi, Flavell, Richard, Akira, Shizuo, ...
Dendritic cells (DC) are key players in the initiation and modulation of adaptive immune responses due to their ability to acquire and present antigen and stimulate T cells. For the induction of...
García, Mónica, Flamez, Daisy, Alexopoulou, Lena, Goldman, Michel, ...
Objective: Viral infections contribute to the pathogenesis of type 1 diabetes. Viruses, or viral products such as double-stranded RNA (dsRNA), affect pancreatic beta cell survival and trigger...
Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1 (2008)
Suzana P. Salcedo, María Ines Marchesini, Hugues Lelouard, Emilie Fugier, Gilles Jolly, Stephanie Balor, ...
Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after Brucella inoculation in intestinal loops,...
Detrimental contribution of the immuno-inhibitor b7-h1 to rabies virus encephalitis. (2008)
Lafon, Monique, Mégret, Françoise, Meuth, Sven G, Simon, Ole, Velandia Romero, Myriam L, Lafage, Mireille, ...
Rabies virus is the etiological agent of an acute encephalitis, which in absence of post exposure treatment is fatal in almost all cases. Virus lethality rests on its ability to evade the immune...
Detrimental contribution of the immuno-inhibitor b7-h1 to rabies virus encephalitis. (2008)
Lafon, Monique, Mégret, Françoise, Meuth, Sven G, Simon, Ole, Velandia Romero, Myriam L, Lafage, Mireille, ...
Rabies virus is the etiological agent of an acute encephalitis, which in absence of post exposure treatment is fatal in almost all cases. Virus lethality rests on its ability to evade the immune...
Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis (2007)
Fazzari, Pietro, Penachioni, Junia, Gianola, Sara, Rossi, Ferdinando, Eickholt, Britta J, Maina, Flavio, ...
Abstract Background Plexins are a large family of transmembrane receptors for the Semaphorins, known for their role in the assembly of neural circuitry. More recently, Plexins have been implicated in...
Ronan Le Goffic, Viviane Balloy, Micheline Lagranderie, Lena Alexopoulou, Nicolas Escriou, Richard Flavell, ...
Influenza A virus (IAV) is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. Recently, we demonstrated, using an in...
& Services References E-mail Alerts Rights & Permissions Reprints (2006)
Vincent Feuillet, Samir Medjane, Isabelle Mondor, Olivier Demaria, Jorge E, Richard A. Flavell, ...
doi:10.1073/pnas.0605200103 This information is current as of March 2007. High-resolution figures, a citation map, links to PubMed and Google Scholar, etc., can be found at:...
Diebold, Sandra S., Montoya, Maria, Unger, Hermann, Alexopoulou, Lena, Roy, Polly, Haswell, Linsey E., ...
Type I interferons (IFN-I) are important cytokines linking innate and adaptive immunity. Plasmacytoid dendritic cells make high levels of IFN-I in response to viral infection and are thought to be...
Pasparakis, Manolis, Alexopoulou, Lena, Grell, Matthias, Pfizenmaier, Klaus, Bluethmann, Horst, Kollias, George
Targeted inactivation of genes in the tumor necrosis factor (TNF)/lymphotoxin (LT) ligand and receptor system has recently revealed essential roles for these molecules in lymphoid tissue development...
Kontoyiannis, Dimitris, Kotlyarov, Alexey, Carballo, Ester, Alexopoulou, Lena, Blackshear, Perry J., Gaestel, Matthias, ...
Interleukin-10 (IL-10) is a key inhibitory signal of inflammatory responses that regulates the production of potentially pathogenic cytokines like tumor necrosis factor (TNF). We show here that the...
Tabeta, Koichi, Georgel, Philippe, Janssen, Edith, Du, Xin, Hoebe, Kasper, Crozat, Karine, ...
Several subsets of dendritic cells have been shown to produce type I IFN in response to viral infections, thereby assisting the natural killer cell-dependent response that eliminates the pathogen....
Recognition of single-stranded RNA viruses by Toll-like receptor 7
Lund, Jennifer M., Alexopoulou, Lena, Sato, Ayuko, Karow, Margaret, Adams, Niels C., Gale, Nicholas W., ...
Viral infection of mammalian host results in the activation of innate immune responses. Toll-like receptors (TLRs) have been shown to mediate the recognition of many types of pathogens, including...
Baratin, Myriam, Roetynck, Sophie, Lépolard, Catherine, Falk, Christine, Sawadogo, Serge, Uematsu, Satoshi, ...
IFN-γ secretion by natural killer (NK) cells is pivotal to several tumor and viral immune responses, during which NK and dendritic cells cooperation is required. We show here that macrophages are...
Goffic, Ronan Le, Balloy, Viviane, Lagranderie, Micheline, Alexopoulou, Lena, Escriou, Nicolas, Flavell, Richard, ...
Influenza A virus (IAV) is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. Recently, we demonstrated, using an in...
Pasparakis, Manolis, Alexopoulou, Lena, Grell, Matthias, Pfizenmaier, Klaus, Bluethmann, Horst, Kollias, George
Targeted inactivation of genes in the tumor necrosis factor (TNF)/lymphotoxin (LT) ligand and receptor system has recently revealed essential roles for these molecules in lymphoid tissue development...
Kontoyiannis, Dimitris, Kotlyarov, Alexey, Carballo, Ester, Alexopoulou, Lena, Blackshear, Perry J., Gaestel, Matthias, ...
Interleukin-10 (IL-10) is a key inhibitory signal of inflammatory responses that regulates the production of potentially pathogenic cytokines like tumor necrosis factor (TNF). We show here that the...
Tabeta, Koichi, Georgel, Philippe, Janssen, Edith, Du, Xin, Hoebe, Kasper, Crozat, Karine, ...
Several subsets of dendritic cells have been shown to produce type I IFN in response to viral infections, thereby assisting the natural killer cell-dependent response that eliminates the pathogen....
Recognition of single-stranded RNA viruses by Toll-like receptor 7
Lund, Jennifer M., Alexopoulou, Lena, Sato, Ayuko, Karow, Margaret, Adams, Niels C., Gale, Nicholas W., ...
Viral infection of mammalian host results in the activation of innate immune responses. Toll-like receptors (TLRs) have been shown to mediate the recognition of many types of pathogens, including...
Baratin, Myriam, Roetynck, Sophie, Lépolard, Catherine, Falk, Christine, Sawadogo, Serge, Uematsu, Satoshi, ...
IFN-γ secretion by natural killer (NK) cells is pivotal to several tumor and viral immune responses, during which NK and dendritic cells cooperation is required. We show here that macrophages are...
Goffic, Ronan Le, Balloy, Viviane, Lagranderie, Micheline, Alexopoulou, Lena, Escriou, Nicolas, Flavell, Richard, ...
Influenza A virus (IAV) is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. Recently, we demonstrated, using an in...
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria
Feuillet, Vincent, Medjane, Samir, Mondor, Isabelle, Demaria, Olivier, Pagni, Philippe P., Galán, Jorge E., ...
Toll-like receptors (TLRs) are key components of the immune system that detect microbial infection and trigger antimicrobial host defense responses. TLR5 is a sensor for monomeric flagellin, which is...
Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis
Fazzari, Pietro, Penachioni, Junia, Gianola, Sara, Rossi, Ferdinando, Eickholt, Britta J, Maina, Flavio, ...
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
Christensen, Sean R., Kashgarian, Michael, Alexopoulou, Lena, Flavell, Richard A., Akira, Shizuo, Shlomchik, Mark J.
Systemic autoimmune disease in humans and mice is characterized by loss of immunologic tolerance to a restricted set of self-nuclear antigens. Autoantigens, such as double-stranded (ds) DNA and the...
Alexopoulou, Lena, Pasparakis, Manolis, Kollias, George
Lymphotoxin (LT)α knockout mice, as well as double LTα/tumor necrosis factor (TNF) knockout mice, show a severe splenic disorganization with nonsegregating T/B cell zones and complete absence of...
Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1
Salcedo, Suzana P, Marchesini, María Ines, Lelouard, Hugues, Fugier, Emilie, Jolly, Gilles, Balor, Stephanie, ...
Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after Brucella inoculation in intestinal loops,...