Di Bona, Danilo, Vasto, Sonya, Capurso, Cristiano, Christiansen, Lene, Deiana, Luca, Franceschi, Claudio, ...
Several studies have assessed changes in frequency of −174 interleukin (IL)-6 single nucleotide polymorphism (SNP) with age. If IL-6 tracks with disability and age-related diseases, then there...
Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins (2008)
Kimura, Masayuki, Hjelmborg, Jacob V. B., Gardner, Jeffrey P., Bathum, Lise, Brimacombe, Michael, Lu, Xiaobin, ...
Leukocyte telomere length, representing the mean length of all telomeres in leukocytes, is ostensibly a bioindicator of human aging. The authors hypothesized that shorter telomeres might forecast...
Tan, Qihua, Christiansen, Lene, Brasch-Andersen, Charlotte, Zhao, Jing, Li, Shuxia, Kruse, Torben A, ...
Abstract Background The etiology of multifactorial human diseases involves complex interactions between numerous environmental factors and alleles of many genes. Efficient statistical tools are...
Estimating haplotype relative risks on human survival in population-based association studies (2005)
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Zhao, Jing H., Yashin, Anatoli I., Vaupel, James W., ...
Association-based linkage disequilibrium (LD) mapping is an increasingly important tool for localizing genes that show potential influence on human aging and longevity. As haplotypes contain more LD...
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Zhao, Jing H., Vach, Werner, Vaupel, James W., ...
Haplotype based linkage disequilibrium (LD) mapping exhibits higher power than the single locus approach because it makes use of the LD information contained in the flanking markers. New statistical...
Bathum, Lise, Christiansen, Lene, Tan, Qihua, Vaupel, James W., Jeune, Bernard, Christensen, Kaare
Previous studies have reported two SNPs and a haplotype marker within the Microsomal Transfer Protein gene associated with extreme longevity. Here, we test this finding in a longitudinal study of...
Assessing genetic association with human survival at multi-allelic loci (2004)
Tan, Qihua, De Benedictis, Giovanna, Yashin, Anatoli I., Bathum, Lise, Christiansen, Lene, Dahlgaard, Jesper, ...
Genetic variation plays an important role in natural selection and population evolution. However, it also presents geneticists interested in aging research with problems in data analysis because of...
Tan, Qihua, Bathum, Lise, Christiansen, Lene, De Benedictis, Giovanna, Dahlgaard, Jesper, Frizner, N, ...
In this paper, we apply logistic regression models to measure genetic association with human survival for highly polymorphic and pleiotropic genes. By modelling genotype frequency as a function of...
Pressler, Tania, Pedersen, Svend Stenvang, Christiansen, Lene, Szaff, Marta, Koch, Christian, Hoiby, Niels
Haemophilus influenzae is a frequent cause of recurrent or chronic lower respiratory tract infections in patients suffering from cystic fibrosis (CF) and other chronic obstructive pulmonary disease...
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Li, Shuxia, Kruse, Torben A., Christensen, Kaare
Although the case-control or the cross-sectional design has been popular in genetic association studies of human longevity, such a design is prone to false positive results due to sampling bias and a...
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Li, Shuxia, Kruse, Torben A., Christensen, Kaare
Although the case-control or the cross-sectional design has been popular in genetic association studies of human longevity, such a design is prone to false positive results due to sampling bias and a...