Deutsch, Eric W, Ball, Catherine A, Berman, Jules J, Bova, G Steven, Brazma, Alvis, Bumgarner, Roger E, ...
One purpose of the biomedical literature is to report results in sufficient detail that the methods of data collection and analysis can be independently replicated and verified. Here we present...
Is Expressed in Restricted Tissues During Embryogenesis and (2007)
Stat Rescues Cytokine, Stat-deficient Human, Cell Line, Andrew C. Oates, Patrik Wollberg, Stephen J. Pratt, ...
Transcription factors of the STAT family are required for cellular responses to multiple signaling molecules.After ligand binding -induced activation of cognate receptors, STAT proteins are...
Definition of the zebrafish genome using flow cytometry and cytogenetic mapping (2007)
Freeman, Jennifer L, Adeniyi, Adeola, Banerjee, Ruby, Dallaire, Stephanie, Maguire, Sean F, Chi, Jianxiang, ...
Abstract Background The zebrafish ( Danio rerio ) is an important vertebrate model organism system for biomedical research. The syntenic conservation between the zebrafish and human genome allows one...
Effects of RAS on the genesis of embryonal rhabdomyosarcoma (2007)
Langenau, David M., Keefe, Matthew D., Storer, Narie Y., Guyon, Jeffrey R., Kutok, Jeffery L., Le, Xiuning, ...
Embryonal rhabdomyosarcoma (ERMS) is a devastating cancer with specific features of muscle differentiation that can result from mutational activation of RAS family members. However, to date, RAS...
Zebrafish orthologs of human muscular dystrophy genes (2007)
Steffen, Leta S, Guyon, Jeffrey R, Vogel, Emily D, Beltre, Rosanna, Pusack, Timothy J, Zhou, Yi, ...
Abstract Background Human muscular dystrophies are a heterogeneous group of genetic disorders which cause decreased muscle strength and often result in premature death. There is no known cure for...
Zebrafish orthologs of human muscular dystrophy genes (2007)
Steffen, Leta S, Guyon, Jeffrey R, Vogel, Emily D, Beltre, Rosanna, Pusack, Timothy J, Zhou, Yi, ...
Abstract Background Human muscular dystrophies are a heterogeneous group of genetic disorders which cause decreased muscle strength and often result in premature death. There is no known cure for...
Keith A. Hultman, Nathan Bahary, Leonard I. Zon, Stephen L. Johnson
The retention of particular genes after the whole genome duplication in zebrafish has given insights into how genes may evolve through partitioning of ancestral functions. We examine the partitioning...
Shepard, Jennifer L., Amatruda, James F., Finkelstein, David, Ziai, James, Finley, K. Rose, Stern, Howard M., ...
Proper chromosome segregation is essential for maintenance of genomic integrity and instability resulting from failure of this process may contribute to cancer. Here, we demonstrate that a mutation...
Hematopoietic stem cell fate is established by the Notch-Runx pathway (2005)
Burns, Caroline Erter, Traver, David, Mayhall, Elizabeth, Shepard, Jennifer L., Zon, Leonard I.
Identifying the molecular pathways regulating hematopoietic stem cell (HSC) specification, self-renewal, and expansion remains a fundamental goal of both basic and clinical biology. Here, we analyzed...
Hematopoietic stem cell fate is established by the Notch-Runx pathway (2005)
Burns, Caroline Erter, Traver, David, Mayhall, Elizabeth, Shepard, Jennifer L., Zon, Leonard I.
Identifying the molecular pathways regulating hematopoietic stem cell (HSC) specification, self-renewal, and expansion remains a fundamental goal of both basic and clinical biology. Here, we analyzed...
Hematopoietic stem cell fate is established by the Notch-Runx pathway (2005)
Burns, Caroline Erter, Traver, David, Mayhall, Elizabeth, Shepard, Jennifer L., Zon, Leonard I.
Identifying the molecular pathways regulating hematopoietic stem cell (HSC) specification, self-renewal, and expansion remains a fundamental goal of both basic and clinical biology. Here, we analyzed...
David G. Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S. Trede, ...
A new gene acting early in red blood cell development is discovered by genetic analysis in zebrafish. The gene encodes a member of a well-known family of transcription factors.
David G. Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S. Trede, ...
Hematopoiesis is precisely orchestrated by lineage-specific DNA-binding proteins that regulate transcription in concert with coactivators and corepressors. Mutations in the zebrafish moonshine (mon)...
Taking the Stem Cell Debate to the Public (2004)
Leonard I. Zon, Laurie Zoloth, Suzanne Kadereit
In response to the Blackburn and Rowley essay on the President's Council on Bioethics, several thought-provoking opinions on ethical challenges in biomedical research are expressed by prominent...
Zebrafish spil promoter drives myeloid-specific expression in stable transgenic fish (2003)
Ward, Alister C., McPhee, Dora O., Condron, Melanie M., Varma, Sony, Cody, Stephen H., Onnebo, Sara M. N., ...
The spi1 (pu.1) gene has recently been identified as a useful marker of early myeloid cells in zebrafish. To enhance the versatility of this organism as a model for studying myeloid development, the...
Zebrafish spil promoter drives myeloid-specific expression in stable transgenic fish (2003)
Ward, Alister, McPhee, Dora O., Condron, Melanie M., Varma, Sony, Cody, Stephen H., Onnebo, Sara M. N., ...
The spi1 (pu.1) gene has recently been identified as a useful marker of early myeloid cells in zebrafish. To enhance the versatility of this organism as a model for studying myeloid development, the...
The zebrafish spil promoter drives myeloid-specific expression in stable transgenic fish (2003)
Ward, Alister, McPhee, Dora O., Condron, Melanie M., Varma, Sony, Cody, Stephen H., Onnebo, Sara M. N., ...
The spi1 (pu.1) gene has recently been identified as a useful marker of early myeloid cells in zebrafish. To enhance the versatility of this organism as a model for studying myeloid development, the...
Lieschke, Graham J., Oates, Andrew C., Paw, Barry H., Thompson, Margaret A., Hall, Nathan E., Ward, Alister C., ...
The mammalian transcription factor SPI-1 (synonyms: SPI1, PU.1, or Sfpi1) plays a critical role in myeloid development. To examine early myeloid commitment in the zebrafish embryo, we isolated a gene...
Lieschke, Graham J., Oates, Andrew C., Paw, Barry H., Thompson, Margaret A., Hall, Nathan E., Ward, Alister, ...
The mammalian transcription factor SPI-1 (synonyms: SPI1, PU.1, or Sfpi1) plays a critical role in myeloid development. To examine early myeloid commitment in the zebrafish embryo, we isolated a gene...
Lieschke, Graham J., Oates, Andrew C., Paw, Barry H., Thompson, Margaret A., Hall, Nathan E., Ward, Alister, ...
The mammalian transcription factor SPI-1 (synonyms: SPI1, PU.1, or Sfpi1) plays a critical role in myeloid development. To examine early myeloid commitment in the zebrafish embryo, we isolated a gene...
The LN54 Radiation Hybrid Map of Zebrafish Expressed Sequences (2001)
Hukriede, Neil, Fisher, Dan, Epstein, Jonathan, Joly, Lucille, Tellis, Patricia, Zhou, Yi, ...
The LN54 Radiation Hybrid Map of Zebrafish Expressed Sequences (2001)
Hukriede, Neil, Fisher, Dan, Epstein, Jonathan, Joly, Lucille, Tellis, Patricia, Zhou, Yi, ...
The LN54 Radiation Hybrid Map of Zebrafish Expressed Sequences (2001)
Hukriede, Neil, Fisher, Dan, Epstein, Jonathan, Joly, Lucille, Tellis, Patricia, Zhou, Yi, ...
Liao, Eric C., Paw, Barry H., Oates, Andrew C., Pratt, Stephen J., Postlethwait, John H., Zon, Leonard I.
Tsai, Mindy, Wedemeyer, Jochen, Ganiatsas, Soula, Tam, See-Ying, Zon, Leonard I., Galli, Stephen J.
An important goal of tissue engineering is to achieve reconstitution of specific functionally active cell types by transplantation of differentiated cell populations derived from normal or...
Jessen, Jason R., Meng, Anming, McFarlane, Ramsay J., Paw, Barry H., Zon, Leonard I., Smith, Gerald R., ...
The modification of yeast artificial chromosomes through homologous recombination has become a useful genetic tool for studying gene function and enhancer/promoter activity. However, it is difficult...
Mead, Paul E., Zhou, Yi, Lustig, Kevin D., Huber, Tara L., Kirschner, Marc W., Zon, Leonard I.
We have developed a technique, fast retrieval of gel shift activities (FROGS), that allows for the rapid isolation of proteins that interact with DNA. Using this technique, we have isolated two...
Radiation hybrid mapping of the zebrafish genome
Hukriede, Neil A., Joly, Lucille, Tsang, Michael, Miles, Jennifer, Tellis, Patricia, Epstein, Jonathan A., ...
The zebrafish is an excellent genetic system for the study of vertebrate development and disease. In an effort to provide a rapid and robust tool for zebrafish gene mapping, a panel of radiation...
Ganiatsas, Soula, Kwee, Lia, Fujiwara, Yuko, Perkins, Andrew, Ikeda, Tohru, Labow, Mark A., ...
SEK1 (MKK4/JNKK) is a mitogen-activated protein kinase activator that has been shown to participate in vitro in two stress-activated cascades terminating with the SAPK and p38 kinases. To define the...
Chayama, Kosuke, Papst, Philip J., Garrington, Timothy P., Pratt, Joanne C., Ishizuka, Tamotsu, Webb, Saiphone, ...
Cross-linking of the high-affinity IgE receptor (FcɛRI) on mast cells with IgE and multivalent antigen triggers mitogen-activated protein (MAP) kinase activation and cytokine gene expression. We...
Liu, Ting Xi, Zhou, Yi, Kanki, John P., Deng, Min, Rhodes, Jennifer, Yang, Hong Wei, ...
Recurring interstitial loss of all or part of the long arm of chromosome 5, del(5q), is a hallmark of myelodysplastic syndrome and acute myeloid leukemia. Although the genes affected by these changes...
The LN54 Radiation Hybrid Map of Zebrafish Expressed Sequences
Hukriede, Neil, Fisher, Dan, Epstein, Jonathan, Joly, Lucille, Tellis, Patricia, Zhou, Yi, ...
To increase the density of a gene map of the zebrafish, Danio rerio, we have placed 3119 expressed sequence tags (ESTs) and cDNA sequences on the LN54 radiation hybrid (RH) panel. The ESTs and genes...
Liao, Eric C., Paw, Barry H., Oates, Andrew C., Pratt, Stephen J., Postlethwait, John H., Zon, Leonard I.
SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remains...
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish
Langenau, David M., Ferrando, Adolfo A., Traver, David, Kutok, Jeffery L., Hezel, John-Paul D., Kanki, John P., ...
Transgenic zebrafish that express GFP under control of the T cell-specific tyrosine kinase (lck) promoter were used to analyze critical aspects of the immune system, including patterns of T cell...
Taking the Stem Cell Debate to the Public
Zon, Leonard I, Zoloth, Laurie, Kadereit, Suzanne
In response to the Blackburn and Rowley essay on the President's Council on Bioethics, several thought-provoking opinions on ethical challenges in biomedical research are expressed by prominent...
Ransom, David G, Bahary, Nathan, Niss, Knut, Traver, David, Burns, Caroline, Trede, Nikolaus S, ...
Hematopoiesis is precisely orchestrated by lineage-specific DNA-binding proteins that regulate transcription in concert with coactivators and corepressors. Mutations in the zebrafish moonshine (mon)...
Hematopoietic gene expression profile in zebrafish kidney marrow
Song, Huai-Dong, Sun, Xiao-Jian, Deng, Min, Zhang, Guo-Wei, Zhou, Yi, Wu, Xin-Yan, ...
The zebrafish kidney marrow is considered to be the organ of definitive hematopoiesis, analogous to the mammalian bone marrow. We have sequenced 26,143 ESTs and isolated 304 cDNAs with putative...
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., ...
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving...
Ferroportin1 is required for normal iron cycling in zebrafish
Fraenkel, Paula G., Traver, David, Donovan, Adriana, Zahrieh, David, Zon, Leonard I.
Missense mutations in ferroportin1 (fpn1), an intestinal and macrophage iron exporter, have been identified between transmembrane helices 3 and 4 in the zebrafish anemia mutant weissherbst...
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility
Shepard, Jennifer L., Amatruda, James F., Stern, Howard M., Subramanian, Aravind, Finkelstein, David, Ziai, James, ...
A major goal of cancer research has been to identify genes that contribute to cancer formation. The similar pathology between zebrafish and human tumors, as well as the past success of large-scale...
Hematopoietic stem cell fate is established by the Notch–Runx pathway
Burns, Caroline Erter, Traver, David, Mayhall, Elizabeth, Shepard, Jennifer L., Zon, Leonard I.
Identifying the molecular pathways regulating hematopoietic stem cell (HSC) specification, self-renewal, and expansion remains a fundamental goal of both basic and clinical biology. Here, we analyzed...
Tsai, Mindy, Wedemeyer, Jochen, Ganiatsas, Soula, Tam, See-Ying, Zon, Leonard I., Galli, Stephen J.
An important goal of tissue engineering is to achieve reconstitution of specific functionally active cell types by transplantation of differentiated cell populations derived from normal or...
Jessen, Jason R., Meng, Anming, McFarlane, Ramsay J., Paw, Barry H., Zon, Leonard I., Smith, Gerald R., ...
The modification of yeast artificial chromosomes through homologous recombination has become a useful genetic tool for studying gene function and enhancer/promoter activity. However, it is difficult...
Mead, Paul E., Zhou, Yi, Lustig, Kevin D., Huber, Tara L., Kirschner, Marc W., Zon, Leonard I.
We have developed a technique, fast retrieval of gel shift activities (FROGS), that allows for the rapid isolation of proteins that interact with DNA. Using this technique, we have isolated two...
Radiation hybrid mapping of the zebrafish genome
Hukriede, Neil A., Joly, Lucille, Tsang, Michael, Miles, Jennifer, Tellis, Patricia, Epstein, Jonathan A., ...
The zebrafish is an excellent genetic system for the study of vertebrate development and disease. In an effort to provide a rapid and robust tool for zebrafish gene mapping, a panel of radiation...
Ganiatsas, Soula, Kwee, Lia, Fujiwara, Yuko, Perkins, Andrew, Ikeda, Tohru, Labow, Mark A., ...
SEK1 (MKK4/JNKK) is a mitogen-activated protein kinase activator that has been shown to participate in vitro in two stress-activated cascades terminating with the SAPK and p38 kinases. To define the...
Chayama, Kosuke, Papst, Philip J., Garrington, Timothy P., Pratt, Joanne C., Ishizuka, Tamotsu, Webb, Saiphone, ...
Cross-linking of the high-affinity IgE receptor (FcɛRI) on mast cells with IgE and multivalent antigen triggers mitogen-activated protein (MAP) kinase activation and cytokine gene expression. We...
Liu, Ting Xi, Zhou, Yi, Kanki, John P., Deng, Min, Rhodes, Jennifer, Yang, Hong Wei, ...
Recurring interstitial loss of all or part of the long arm of chromosome 5, del(5q), is a hallmark of myelodysplastic syndrome and acute myeloid leukemia. Although the genes affected by these changes...
The LN54 Radiation Hybrid Map of Zebrafish Expressed Sequences
Hukriede, Neil, Fisher, Dan, Epstein, Jonathan, Joly, Lucille, Tellis, Patricia, Zhou, Yi, ...
To increase the density of a gene map of the zebrafish, Danio rerio, we have placed 3119 expressed sequence tags (ESTs) and cDNA sequences on the LN54 radiation hybrid (RH) panel. The ESTs and genes...
Liao, Eric C., Paw, Barry H., Oates, Andrew C., Pratt, Stephen J., Postlethwait, John H., Zon, Leonard I.
SCL/Tal-1 is a transcription factor necessary for hematopoietic stem cell differentiation. Although SCL is also expressed in endothelial and neural progenitors, SCL function in these cells remains...
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish
Langenau, David M., Ferrando, Adolfo A., Traver, David, Kutok, Jeffery L., Hezel, John-Paul D., Kanki, John P., ...
Transgenic zebrafish that express GFP under control of the T cell-specific tyrosine kinase (lck) promoter were used to analyze critical aspects of the immune system, including patterns of T cell...
Taking the Stem Cell Debate to the Public
Zon, Leonard I, Zoloth, Laurie, Kadereit, Suzanne
In response to the Blackburn and Rowley essay on the President's Council on Bioethics, several thought-provoking opinions on ethical challenges in biomedical research are expressed by prominent...
Ransom, David G, Bahary, Nathan, Niss, Knut, Traver, David, Burns, Caroline, Trede, Nikolaus S, ...
Hematopoiesis is precisely orchestrated by lineage-specific DNA-binding proteins that regulate transcription in concert with coactivators and corepressors. Mutations in the zebrafish moonshine (mon)...
Hematopoietic gene expression profile in zebrafish kidney marrow
Song, Huai-Dong, Sun, Xiao-Jian, Deng, Min, Zhang, Guo-Wei, Zhou, Yi, Wu, Xin-Yan, ...
The zebrafish kidney marrow is considered to be the organ of definitive hematopoiesis, analogous to the mammalian bone marrow. We have sequenced 26,143 ESTs and isolated 304 cDNAs with putative...
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
Berghmans, Stéphane, Murphey, Ryan D., Wienholds, Erno, Neuberg, Donna, Kutok, Jeffery L., Fletcher, Christopher D. M., ...
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving...
Ferroportin1 is required for normal iron cycling in zebrafish
Fraenkel, Paula G., Traver, David, Donovan, Adriana, Zahrieh, David, Zon, Leonard I.
Missense mutations in ferroportin1 (fpn1), an intestinal and macrophage iron exporter, have been identified between transmembrane helices 3 and 4 in the zebrafish anemia mutant weissherbst...
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility
Shepard, Jennifer L., Amatruda, James F., Stern, Howard M., Subramanian, Aravind, Finkelstein, David, Ziai, James, ...
A major goal of cancer research has been to identify genes that contribute to cancer formation. The similar pathology between zebrafish and human tumors, as well as the past success of large-scale...
Hematopoietic stem cell fate is established by the Notch–Runx pathway
Burns, Caroline Erter, Traver, David, Mayhall, Elizabeth, Shepard, Jennifer L., Zon, Leonard I.
Identifying the molecular pathways regulating hematopoietic stem cell (HSC) specification, self-renewal, and expansion remains a fundamental goal of both basic and clinical biology. Here, we analyzed...
Hultman, Keith A, Bahary, Nathan, Zon, Leonard I, Johnson, Stephen L
The retention of particular genes after the whole genome duplication in zebrafish has given insights into how genes may evolve through partitioning of ancestral functions. We examine the partitioning...
Zebrafish orthologs of human muscular dystrophy genes
Steffen, Leta S, Guyon, Jeffrey R, Vogel, Emily D, Beltre, Rosanna, Pusack, Timothy J, Zhou, Yi, ...
Bansal, Dimple, Scholl, Claudia, Fröhling, Stefan, McDowell, Elizabeth, Lee, Benjamin H., Döhner, Konstanze, ...
HOX genes have emerged as critical effectors of leukemogenesis, but the mechanisms that regulate their expression in leukemia are not well understood. Recent data suggest that the caudal homeobox...
Analysis of thrombocyte development in CD41-GFP transgenic zebrafish
Lin, Hui-Feng, Traver, David, Zhu, Hao, Dooley, Kimberly, Paw, Barry H., Zon, Leonard I., ...
Thrombocytes are the nucleated equivalent of platelets in nonmammalian vertebrates such as the zebrafish, Danio rerio. We have cloned zebrafish CD41 cDNA (αIIb, glycoprotein IIb [GPIIb]) and its...
Mutant-specific gene programs in the zebrafish
Weber, Gerhard J., Choe, Sung E., Dooley, Kimberly A., Paffett-Lugassy, Noëlle N., Zhou, Yi, Zon, Leonard I.
Hematopoiesis involves the production of stem cells, followed by the orchestrated differentiation of the blood lineages. Genetic screens in zebrafish have identified mutants with defects that disrupt...
MacDonald, Brian A., Sund, Malin, Grant, Marianne A., Pfaff, Kathleen L., Holthaus, Kathryn, Zon, Leonard I., ...
Goodpasture syndrome is an autoimmune vascular disease associated with kidney and lung failure, with pathogenic circulating autoantibodies targeted to a set of discontinuous epitope sequences within...
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer
Shepard, Jennifer L., Amatruda, James F., Finkelstein, David, Ziai, James, Finley, K. Rose, Stern, Howard M., ...
Proper chromosome segregation is essential for maintenance of genomic integrity and instability resulting from failure of this process may contribute to cancer. Here, we demonstrate that a mutation...
Definition of the zebrafish genome using flow cytometry and cytogenetic mapping
Freeman, Jennifer L, Adeniyi, Adeola, Banerjee, Ruby, Dallaire, Stephanie, Maguire, Sean F, Chi, Jianxiang, ...
Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110
Trede, Nikolaus S., Medenbach, Jan, Damianov, Andrey, Hung, Lee-Hsueh, Weber, Gerhard J., Paw, Barry H., ...
The spliceosome cycle consists of assembly, catalysis, and recycling phases. Recycling of postspliceosomal U4 and U6 small nuclear ribonucleoproteins (snRNPs) requires p110/SART3, a general splicing...
Le, Xiuning, Langenau, David M., Keefe, Matthew D., Kutok, Jeffery L., Neuberg, Donna S., Zon, Leonard I.
RAS family members are among the most frequently mutated oncogenes in human cancers. Given the utility of zebrafish in both chemical and genetic screens, developing RAS-induced cancer models will...
Effects of RAS on the genesis of embryonal rhabdomyosarcoma
Langenau, David M., Keefe, Matthew D., Storer, Narie Y., Guyon, Jeffrey R., Kutok, Jeffery L., Le, Xiuning, ...
Embryonal rhabdomyosarcoma (ERMS) is a devastating cancer with specific features of muscle differentiation that can result from mutational activation of RAS family members. However, to date, RAS...
The Zebra fish cassiopeia Mutant Reveals that SIL Is Required for Mitotic Spindle Organization▿ §
Pfaff, Kathleen L., Straub, Christian T., Chiang, Ken, Bear, Daniel M., Zhou, Yi, Zon, Leonard I.
A critical step in cell division is formation of the mitotic spindle, which is a bipolar array of microtubules that mediates chromosome separation. Here, we report that the SCL-interrupting locus...
Imamura, Shintaro, Uchiyama, Junzo, Koshimizu, Eriko, Hanai, Jun-ichi, Raftopoulou, Christina, Murphey, Ryan D., ...
Although it is clear that telomerase expression is crucial for the maintenance of telomere homeostasis, there is increasing evidence that the TERT protein can have physiological roles that are...
Functional conservation of erythropoietin signaling in zebrafish
Paffett-Lugassy, Noëlle, Hsia, Nelson, Fraenkel, Paula G., Paw, Barry, Leshinsky, Irene, Barut, Bruce, ...
Erythropoietin (Epo) and its cognate receptor (EpoR) are required for maintaining adequate levels of circulating erythrocytes during embryogenesis and adulthood. Here, we report the functional...
Bahary, Nathan, Goishi, Katsutoshi, Stuckenholz, Carsten, Weber, Gerhard, LeBlanc, Jocelyn, Schafer, Christopher A., ...
Vascular endothelial growth factor A (VEGFA) and the type III receptor tyrosine kinase receptors (RTKs) are both required for the differentiation of endothelial cells (vasculogenesis) and for the...
Transferrin-a modulates hepcidin expression in zebrafish embryos
Fraenkel, Paula G., Gibert, Yann, Holzheimer, Jason L., Lattanzi, Victoria J., Burnett, Sarah F., Dooley, Kimberly A., ...
The iron regulatory hormone hepcidin is transcriptionally up-regulated in response to iron loading, but the mechanisms by which iron levels are sensed are not well understood. Large-scale genetic...
Burns, Caroline E., Galloway, Jenna L., Smith, Alexandra C. H., Keefe, Matthew D., Cashman, Timothy J., Paik, Elizabeth J., ...
Defining the genetic pathways essential for hematopoietic stem cell (HSC) development remains a fundamental goal impacting stem cell biology and regenerative medicine. To genetically dissect HSC...