Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction (2006)
Haigis, Marcia C., Guarente, Leonard P.
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1–7. Here, we review recent findings...
Austriaco, Nicanor R., Guarente, Leonard P.
Budding yeast cells divide asymmetrically, giving rise to a mother and its daughter. Mother cells have a limited division potential, called their lifespan, which ends in proliferation-arrest and...
Austriaco, Nicanor R., Guarente, Leonard P.
Budding yeast cells divide asymmetrically, giving rise to a mother and its daughter. Mother cells have a limited division potential, called their lifespan, which ends in proliferation-arrest and...
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation▿ †
Lombard, David B., Alt, Frederick W., Cheng, Hwei-Ling, Bunkenborg, Jakob, Streeper, Ryan S., Mostoslavsky, Raul, ...
Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here, we...
Genetics of transcription termination /
Thesis (Ph. D.)--Harvard University, 1979.
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
Firestein, Ron, Blander, Gil, Michan, Shaday, Oberdoerffer, Philipp, Ogino, Shuji, Campbell, Jennifer, ...
Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from...